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Current Bladder Dysfunction Reports

Erschienen in:

26.09.2018 | Reconstructed Bladder Function & Dysfunction (M Kaufman, Section Editor)

Shared Pathophysiology of Detrusor Overactivity and Detrusor Underactivity

verfasst von: Henry Collier Wright, Elizabeth Timbrook Brown

Erschienen in: Current Bladder Dysfunction Reports | Ausgabe 4/2018

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Abstract

Purpose of Review

Detrusor overactivity (DO) and the associated symptom complex of overactive bladder (OAB) is well-studied with many treatment options. In contrast, detrusor underactivity (DU) and its associated symptom complex, underactive bladder (UAB), is poorly understood. Researchers have proposed explanations that link OAB and UAB with a common pathophysiology. The purpose of this review is to examine concepts and recent underlying research supporting a shared pathophysiology of DO and DU.

Recent Findings

In 2014, Dr. Michael Chancellor proposed “The Overactive Bladder Progression to Underactive Bladder Hypothesis.” Since then, researchers have conducted several animal and human studies to examine the pathophysiology of OAB and UAB. These studies, which highlight this shared pathophysiology, can be categorized broadly into neurogenic, myogenic, urothelial dysfunction, and idiopathic etiologies. Autonomous bladder micromotions are another proposed mechanism of shared OAB and UAB pathophysiology.

Summary

UAB is poorly understood in comparison to OAB, yet the concept of a shared pathophysiology could shed light into future research, technology, and pharmacologic interventions to adequately manage patients with these conditions.

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Titel: Shared Pathophysiology of Detrusor Overactivity and Detrusor Underactivity
verfasst von: Henry Collier Wright
Elizabeth Timbrook Brown
Publikationsdatum: 26.09.2018
Verlag: Springer US
Erschienen in: Current Bladder Dysfunction Reports / Ausgabe 4/2018
Print ISSN: 1931-7212
Elektronische ISSN: 1931-7220
DOI: https://doi.org/10.1007/s11884-018-0490-3

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Abstract

Purpose of Review

Recent Findings

Summary

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