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Immunologic Research
Erschienen in: Immunologic Research 1-3/2009

01.07.2009

Shortening the immunodeficient period after hematopoietic stem cell transplantation

verfasst von: Isabelle André-Schmutz, Emmanuelle Six, Delphine Bonhomme, Julien Rouiller, Liliane Dal Cortivo, Alain Fischer, Marina Cavazzana-Calvo

Erschienen in: Immunologic Research | Ausgabe 1-3/2009

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Abstract

The delayed reconstitution of the T-lymphoid compartment represents a major clinical challenge after HLA-mismatched hematopoietic stem cell transplantation. The generation of new T lymphocytes deriving from transplanted hematopoietic stem cells requires several months, a period associated with an increased risk of opportunistic infections and relapses. Recently, the early steps of human lymphopoiesis and the nature of the thymus-seeding progenitors were described. Moreover several scientific groups succeeded to generate T-cell precursors from murine and human hematopoietic stem cells in vitro by transitory exposition to Notch-ligands. Here we summarize and discuss these results and their possible usage in the development of new cell therapies to shorten the immunodeficient period following hematopoietic stem cell transplantation.
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Metadaten
Titel
Shortening the immunodeficient period after hematopoietic stem cell transplantation
verfasst von
Isabelle André-Schmutz
Emmanuelle Six
Delphine Bonhomme
Julien Rouiller
Liliane Dal Cortivo
Alain Fischer
Marina Cavazzana-Calvo
Publikationsdatum
01.07.2009
Verlag
Humana Press Inc
Erschienen in
Immunologic Research / Ausgabe 1-3/2009
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-008-8080-7

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