nach oben

Cancer and Metastasis Reviews

Erschienen in:

01.06.2008 | NON-THEMATIC REVIEW

Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species

verfasst von: Wen-Sheng Wu, Jia-Ru Wu, Chi-Tan Hu

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 2/2008

Einloggen, um Zugang zu erhalten

Abstract

Signal transduction exerted by the microenvironment around the primary tumor locus may trigger tumor metastasis especially at the migration stage. Sustained mitogen activated protein kinase (MAPK) signaling involved in uncontrolled tumor cell migration rely on the cross talks between integrin, receptor tyrosine kinase (RTK) and protein kinase C (PKC). The molecular mechanisms for cross talking between these migration-related signal cascades leading to sustained cell migration are reviewed, focusing on the focal adhesion scaffold protein paxillin as the platform for signal integration. We proposed reactive oxygen species (ROS) as the critical signal messenger sustaining these signal cascades. For the cross talk of integrin with RTK, ROS may suppress paxillin-associated protein tyrosine phosphatase (PTP–PEST) relieving its negative regulatory effects. For the cross talk of integrin with PKC, PKC itself may phosphorylate integrin or paxillin-associated focal adhesion proteins to induce generation of ROS which may reactivate PKC. In the future, ROS will be validated as the promising therapeutic targets for prevention of tumor metastasis.

Christofori, G. (2006). New signals from the invasive front (review). Nature, 441(7092), 444–450.PubMedCrossRef

Cairns, R. A., Khokha, R., & Hill, R. P. (2003). Molecular mechanisms of tumor invasion and metastasis: An integrated view. Current Molecular Medicine, 3(7), 659–671.PubMedCrossRef

Sung, S. Y., Hsieh, C. L., Wu, D., Chung, L. W., & Johnstone, P. A. (2007). Tumor microenvironment promotes cancer progression, metastasis, and therapeutic resistance. Current Problems in Cancer, 31(2), 36–100.PubMedCrossRef

Ridley, A. J., Schwartz, M. A., Burridge, K., Firtel, R. A., Ginsberg, M. H., Borisy, G., et al. (2003). Cell migration: Integrating signals from front to back. Science, 302(5651), 1704–1709.PubMedCrossRef

Gao, C. F., & Vande Woude, G. F. (2005). HGF/SF-Met signaling in tumor progression. Cell Research, 15(1), 49–51.PubMedCrossRef

Bierie, B., & Moses, H. L. (2006). Tumour microenvironment: TGFbeta: The molecular Jekyll and Hyde of cancer. Nature Reviews Cancer, 6(7), 506–520.PubMedCrossRef

Kim, H., & Muller, W. J. (1999). The role of the epidermal growth factor receptor family in mammary tumorigenesis and metastasis. Experimental Cell Research, 253(1), 78–87.PubMedCrossRef

Qiang, Y. W., Walsh, K., Yao, L., Kedei, N., Blumberg, P. M., Rubin, J. S., et al. (2005). Wnts induce migration and invasion of myeloma plasma cells. Blood, 106(5), 1786–1793.PubMedCrossRef

Johnson, G. L., & Lapadat, R. (2002). Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science, 298(5600), 1911–1912.PubMedCrossRef

10.

Huang, C., Jacobson, K., & Schaller, M. D. (2004). MAP kinases and cell migration. Journal of Cell Science, 117(Pt 20), 4619–4628.PubMedCrossRef

11.

Galabova-Kovacs, G., Kolbus, A., Matzen, D., Meissl, K., Piazzolla, D., Rubiolo, C., et al. (2006). ERK and beyond: insights from B-Raf and Raf-1 conditional knockouts. Cell Cycle, 5(14), 1514–1518.PubMed

12.

von Kriegsheim, A., Pitt, A., Grindlay, G. J., Kolch, W., & Dhillon, A. S. (2006). Regulation of the Raf–MEK–ERK pathway by protein phosphatase 5. Nature Cell Biology, 8(9), 1011–1016.CrossRef

13.

Rajalingam, K., Wunder, C., Brinkmann, V., Churin, Y., Hekman, M., Sievers, C., et al. (2005). Prohibitin is required for Ras-induced Raf–MEK–ERK activation and epithelial cell migration. Nature Cell Biology, 7(8), 837–843.PubMedCrossRef

14.

Giehl, K. (2005). Oncogenic Ras in tumour progression and metastasis. Biological Chemistry, 386(3), 193–205.PubMedCrossRef

15.

Shin, I., Kim, S., Song, H., Kim, H. R., & Moon, A. (2005). H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells. Journal of Biological Chemistry, 280(15), 14675–14683.PubMedCrossRef

16.

Veit, C., Genze, F., Menke, A., Hoeffert, S., Gress, T. M., Gierschik, P., et al. (2004). Activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and invasion of pancreatic carcinoma cells. Cancer Research, 64(15), 5291–5300.PubMedCrossRef

17.

Woods, D., Cherwinski, H., Venetsanakos, E., Bhat, A., Gysin, S., Humbert, M., et al. (2001). Induction of beta3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-extracellular signal-regulated kinase signaling pathway. Molecular and Cellular Biology, 21(9), 3192–3205.PubMedCrossRef

18.

Imamichi, Y., & Menke, A. (2007). Signaling pathways involved in collagen-induced disruption of the E-cadherin complex during epithelial–mesenchymal transition. Cells Tissues Organs, 185(1–3), 180–190.PubMedCrossRef

19.

Yan, F., Hui, Y. N., Li, Y. J., Guo, C. M., & Meng, H. (2007). Epidermal growth factor receptor in cultured human retinal pigment epithelial cells. Ophthalmologica, 221(4), 244–250.PubMedCrossRef

20.

Matsumoto, T., Yokote, K., Tamura, K., Takemoto, M., Ueno, H., Saito, Y., et al. (1999). Platelet-derived growth factor activates p38 mitogen-activated protein kinase through a Ras-dependent pathway that is important for actin reorganization and cell migration. Journal of Biological Chemistry, 274(20), 13954–13960.PubMedCrossRef

21.

Guo, W., & Giancotti, F. G. (2004). Integrin signalling during tumour progression. Nature Reviews. Molecular cell biology, 5(10), 816–826.PubMedCrossRef

22.

Kurayoshi, M., Oue, N., Yamamoto, H., Kishida, M., Inoue, A., Asahara, T., et al. (2006). Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion. Cancer Research, 66(21), 10439–10448.PubMedCrossRef

23.

Abassi, Y. A., & Vuori, K. (2002). Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling. EMBO Journal, 21(17), 4571–4582.PubMedCrossRef

24.

Hsia, D. A., Mitra, S. K., Hauck, C. R., Streblow, D. N., Nelson, J. A., Ilic, D., et al. (2003). Differential regulation of cell motility and invasion by FAK. Journal of Cell Biology, 160(5), 753–767.PubMedCrossRef

25.

Rucci, N., DiGiacinto, C., Orru, L., Millimaggi, D., Baron, R., & Teti, A. (2005). A novel protein kinase C alpha-dependent signal to ERK1/2 activated by alphaVbeta3 integrin in osteoclasts and in Chinese hamster ovary (CHO) cells. Journal of Cell Science, 118(Pt 15), 3263–3275.PubMedCrossRef

26.

Desban, N., Lissitzky, J. C., Rousselle, P., & Duband, J. L. (2006). alpha1beta1-integrin engagement to distinct laminin-1 domains orchestrates spreading, migration and survival of neural crest cells through independent signaling pathways. Journal of Cell Science, 119(Pt 15), 3206–3218.PubMedCrossRef

27.

Kermorgant, S., Zicha, D., & Parker, P. J. (2004). PKC controls HGF-dependent c-Met traffic, signalling and cell migration. EMBO Journal, 23(19), 3721–3734.PubMedCrossRef

28.

Tian, Y. C., Chen, Y. C., Chang, C. T., Hung, C. C., Wu, M. S., Phillips, A., et al. (2007). Epidermal growth factor and transforming growth factor-beta1 enhance HK-2 cell migration through a synergistic increase of matrix metalloproteinase and sustained activation of ERK signaling pathway. Experimental Cell Research, 313(11), 2367–2377.PubMedCrossRef

29.

Mercer, K., Giblett, S., Oakden, A., Brown, J., Marais, R., & Pritchard, C. (2005). A-Raf and Raf-1 work together to influence transient ERK phosphorylation and Gl/S cell cycle progression. Oncogene, 24(33), 5207–5217.PubMedCrossRef

30.

Kim, S. J., Kim, S. Y., Kwon, C. H., & Kim, Y. K. (2007). Differential effect of FGF and PDGF on cell proliferation and migration in osteoblastic cells. Growth Factors, 25(2), 77–86.PubMedCrossRef

31.

McCawley, L. J., Li, S., Wattenberg, E. V., & Hudson, L. G. (1999). Sustained activation of the mitogen-activated protein kinase pathway. A mechanism underlying receptor tyrosine kinase specificity for matrix metalloproteinase-9 induction and cell migration. Journal of Biological Chemistry, 274(7), 4347–4353.PubMedCrossRef

32.

Krueger, J. S., Keshamouni, V. G., Atanaskova, N., & Reddy, K. B. (2001). Temporal and quantitative regulation of mitogen-activated protein kinase (MAPK) modulates cell motility and invasion. Oncogene, 20(31), 4209–4218.PubMedCrossRef

33.

lin, E. J., Opresko, L. K., Wells, A., Wiley, H. S., & Lauffenburger, D. A. (2007). EGF-receptor- mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation. Journal of Cell Science, 120(Pt 20), 3688–3699.

34.

Suyama, K., Shapiro, I., Guttman, M., & Hazan, R. B. (2002). A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor. Cancer Cell, 2(4), 301–314.PubMedCrossRef

35.

Pukac, L., Huangpu, J., & Karnovsky, M. J. (1998). Platelet-derived growth factor-BB, insulin-like growth factor-I, and phorbol ester activate different signaling pathways for stimulation of vascular smooth muscle cell migration. Experimental Cell Research, 242(2), 548–560.PubMedCrossRef

36.

Wu, W. S., Tsai, R. K., Chang, C. H., Wang, S., Wu, J. R., & Chang, Y. X. (2006). Reactive oxygen species mediated sustained activation of protein kinase C alpha and extracellular signal-regulated kinase for migration of human hepatoma cell Hepg2. Molecular Cancer Research, 4(10), 747–758.PubMedCrossRef

37.

Levy, Y., Ronen, D., Bershadsky, A. D., & Zick, Y. (2003). Sustained induction of ERK, protein kinase B, and p70 S6 kinase regulates cell spreading and formation of F-actin microspikes upon ligation of integrins by galectin-8, a mammalian lectin. Journal of Biological Chemistry, 278(16), 14533–14542.PubMedCrossRef

38.

Meier, F., Busch, S., Gast, D., Goppert, A., Altevogt, P., Maczey, E., et al. (2006). The adhesion molecule L1 (CD171) promotes melanoma progression. International Journal of Cancer, 119(3), 549–555.CrossRef

39.

40.

Katz, M., Amit, I., & Yarden, Y. (2007). Regulation of MAPKs by growth factors and receptor tyrosine kinases. Biochimica et Biophysica Acta, 1773(8), 1161–1176.PubMed

41.

Silletti, S., Yebra, M., Perez, B., Cirulli, V., McMahon, M., & Montgomery, A. M. (2004). Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion. Journal of Biological Chemistry, 279(28), 28880–28888.PubMedCrossRef

42.

Ishibe, S., Joly, D., Liu, Z. X., & Cantley, L. G. (2004). Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis. Molecular Cell, 16(2), 257–267.PubMedCrossRef

43.

Giancotti, F. G., & Ruoslahti, E. (1999). Integrin signaling. Science, 285(5430), 1028–1032.PubMedCrossRef

44.

Mitra, S. K., & Schlaepfer, D. D. (2006). Integrin-regulated FAK-Src signaling in normal and cancer cells. Current Opinion in Cell Biology, 18(5), 516–523.PubMedCrossRef

45.

Hood, J. D., & Cheresh, D. A. (2002). Role of integrins in cell invasion and migration. Nature Reviews. Cancer, 2(2), 91–100.PubMedCrossRef

46.

Chiarugi, P., & Fiaschi, T. (2007). Redox signalling in anchorage-dependent cell growth. Cell Signal, 19(4), 672–682.PubMedCrossRef

47.

Friedman, A., & Perrimon, N. (2006). A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling. Nature, 444(7116), 230–234.PubMedCrossRef

48.

Giancotti, F. G., & Tarone, G. (2003). Positional control of cell fate through joint integrin/receptor protein kinase signaling. Annual Review of Cell and Developmental Biology, 19, 173–206.PubMedCrossRef

49.

Borges, E., Jan, Y., & Ruoslahti, E. (2000). Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain. Journal of Biological Chemistry, 275(51), 39867–39873.PubMedCrossRef

50.

Short, S. M., Boyer, J. L., & Juliano, R. L. (2000). Integrins regulate the linkage between upstream and downstream events in G protein-coupled receptor signaling to mitogen-activated protein kinase. Journal of Biological Chemistry, 275(17), 12970–12977.PubMedCrossRef

51.

Guo, W., Pylayeva, Y., Pepe, A., Yoshioka, T., Muller, W. J., Inghirami, G., et al. (2006). Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell, 126(3), 489–502.PubMedCrossRef

52.

Clemmons, D. R., & Maile, L. A. (2005). Interaction between insulin-like growth factor-I receptor and alphaVbeta3 integrin linked signaling pathways: cellular responses to changes in multiple signaling inputs. Molecular Endocrinology, 19(1), 1–11.PubMedCrossRef

53.

Miyamoto, S., Teramoto, H., Gutkind, J. S., & Yamada, K. M. (1996). Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. Journal of Cell Biology, 135(6 Pt 1), 1633–1642.PubMedCrossRef

54.

Turner, C. E. (2000). Paxillin interactions. Journal of Cell Science, 113(Pt 23), 4139–4140.PubMed

55.

Gilcrease, M. Z. (2007). Integrin signaling in epithelial cells. Cancer Letters, 247(1), 1–25.PubMedCrossRef

56.

Li, F., Zhang, Y., & Wu, C. (1999). Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats. Journal of Cell Science, 112(Pt 24), 4589–4599.PubMed

57.

Tu, Y., Li, F., & Wu, C. (1998). Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways. Molecular Biology of the Cell, 9(12), 3367–3382.PubMed

58.

ffrench-Constant, C., & Colognato, H. (2004). Integrins: Versatile integrators of extracellular signals. Trends in Cell Biology, 14(12), 678–686.PubMedCrossRef

59.

Chan, P. C., Chen, S. Y., Chen, C. H., & Chen, H. C. (2006). Crosstalk between hepatocyte growth factor and integrin signaling pathways. Journal of Biomedical Science, 13(2), 215–223.PubMedCrossRef

60.

Playford, M. P., & Schaller, M. D. (2004). The interplay between Src and integrins in normal and tumor biology. Oncogene, 23, 7928–7946.PubMedCrossRef

61.

Mitra, S. K., & Schlaepfer, D. D. (2006). Integrin-regulated FAK-Src signaling in normal and cancer cells. Current Opinion in Cell Biology, 18(5), 516–523.PubMedCrossRef

62.

Zaidel-Bar, R., Milo, R., Kam, Z., & Geiger, B. (2007). A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions. Journal of Cell Science, 120(Pt 1), 137–148.PubMed

63.

Brown, M. C., & Turner, C. E. (2004). Paxillin: adapting to change. Physiological Reviews, 84(4), 1315–1339.PubMedCrossRef

64.

Waters, C. M., Connell, M. C., Pyne, S., & Pyne, N. J. (2005). c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cells. Cell Signal, 17(2), 263–277.PubMedCrossRef

65.

Mon, N. N., Ito, S., Senga, T., & Hamaguchi, M. (2006). FAK signaling in neoplastic disorders: a linkage between inflammation and cancer. Annals of the New York Academy of Sciences, 1086, 199–212.PubMedCrossRef

66.

Park, S. Y., Li, H., & Avraham, S. (2007). RAFTK/Pyk2 regulates EGF-induced PC12 cell spreading and movement. Cell Signal, 19(2), 289–300.PubMedCrossRef

67.

Monami, G., Gonzalez, E. M., Hellman, M., Gomella, L. G., Baffa, R., Iozzo, R. V., et al. (2006). Proepithelin promotes migration and invasion of 5637 bladder cancer cells through the activation of ERK1/2 and the formation of a paxillin/FAK/ERK complex. Cancer Research, 66(14), 7103–7110.PubMedCrossRef

68.

Lesslie, D. P., Summy, J. M., Parikh, N. U., Fan, F., Trevino, J. G., Sawyer, T. K., et al. (2006). Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases. British Journal of Cancer, 94(11), 1710–1717.PubMed

69.

Ishibe, S., Joly, D., Zhu, X., & Cantley, L. G. (2003). Phosphorylation-dependent paxillin–ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis. Molecular Cell, 12(5), 1275–1285.PubMedCrossRef

70.

Manser, E., Loo, T. H., Koh, C. G., Zhao, Z. S., Chen, X. Q., Tan, L., et al. (1998). PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Molecular Cell, 1(2), 183–192.PubMedCrossRef

71.

West, K. A., Zhang, H., Brown, M. C., Nikolopoulos, S. N., Riedy, M. C., Horwitz, A. F., et al. (2001). The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL). Journal of Cell Biology, 154(1), 161–176.PubMedCrossRef

72.

Nayal, A., Webb, D. J., Brown, C. M., Schaefer, E. M., Vicente-Manzanares, M., & Horwitz, A. R. (2006). Paxillin phosphorylation at Ser273 localizes a GIT1–PIX–PAK complex and regulates adhesion and protrusion dynamics. Journal of Cell Biology, 173(4), 587–589.PubMedCrossRef

73.

Turner, C. E., Brown, M. C., Perrotta, J. A., Riedy, M. C., Nikolopoulos, S. N., McDonald, A. R., et al. (1999). Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF–GAP protein: A role in cytoskeletal remodeling. Journal of Cell Biology, 145(4), 851–863.PubMedCrossRef

74.

Lamorte, L., Rodrigues, S., Sangwan, V., Turner, C. E., & Park, M. (2003). Crk associates with a multimolecular paxillin/GIT2/beta-PIX complex and promotes Rac-dependent relocalization of paxillin to focal contacts. Molecular Biology of the Cell, 14(7), 2818–2831.PubMedCrossRef

75.

Shen, Y., Lyons, P., Cooley, M., Davidson, D., Veillette, A., Salgia, R., et al. (2000). The noncatalytic domain of protein–tyrosine phosphatase–PEST targets paxillin for dephosphorylation in vivo. Journal of Biological Chemistry, 275(2), 1405–1413.PubMedCrossRef

76.

Sastry, S. K., Lyons, P. D., Schaller, M. D., & Burridge, K. (2002). PTP–PEST controls motility through regulation of Rac1. Journal of Cell Science, 115(Pt 22), 4305–4316.PubMedCrossRef

77.

Jamieson, J. S., Tumbarello, D. A., Hallé, M., Brown, M. C., Tremblay, M. L., & Turner, C. E. (2005). Paxillin is essential for PTP–PEST-dependent regulation of cell spreading and motility: a role for paxillin kinase linker. Journal of Cell Science, 118(Pt 24), 5835–5847.PubMedCrossRef

78.

Griner, E. M., & Kazanietz, M. G. (2007). Protein kinase C and other diacylglycerol effectors in cancer. Nature Reviews Cancer, 7(4), 281–294.PubMedCrossRef

79.

Wu, W. S. (2006). The signaling mechanism of ROS in tumor progression. Cancer and Metastasis Reviews, 25(4), 695–705.PubMedCrossRef

80.

Lipscomb, E. A., & Mercurio, A. M. (2005). Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression. Cancer and Metastasis Reviews, 24(3), 413–423.PubMedCrossRef

81.

Oka, M., & Kikkawa, U. (2005). Protein kinase C in melanoma. Cancer and Metastasis Reviews, 24(2), 287–300.PubMedCrossRef

82.

Kiley, S. C., Clark, K. J., Goodnough, M., Welch, D. R., & Jaken, S. (1999). Protein kinase C delta involvement in mammary tumor cell metastasis. Cancer Research, 59(13), 3230–3238.PubMed

83.

Pan, Q., Bao, L. W., Kleer, C. G., Sabel, M. S., Griffith, K. A., Teknos, T. N., et al. (2005). Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy. Cancer Research, 65(18), 8366–8371.PubMedCrossRef

84.

Gopalakrishna, R., & Jaken, S. (2000). Protein kinase C signaling and oxidative stress. Free Radical Biology & Medicine, 28(9), 1349–1361.CrossRef

85.

Gomez, D. E., Skilton, G., Alonso, D. F., & Kazanietz, M. G. (1999). The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (review). Oncology Reports, 6(6), 1363–1370.PubMed

86.

Guan, C. X., Cui, Y. R., Zhang, M., Bai, H. B., Khunkhun, R., & Fang, X. (2007). Intracellular signaling molecules involved in vasoactive intestinal peptide-mediated wound healing in human bronchial epithelial cells. Peptides, 28(9), 1667–1673.PubMedCrossRef

87.

Keshamouni, V. G., Mattingly, R. R., & Reddy, K. B. (2002). Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta. Journal of Biological Chemistry, 277(25), 22558–22565.PubMedCrossRef

88.

Besson, A., Davy, A., Robbins, S. M., & Yong, V. W. (2001). Differential activation of ERKs to focal adhesions by PKC epsilon is required for PMA-induced adhesion and migration of human glioma cells. Oncogene, 20(50), 7398–7407.PubMedCrossRef

89.

90.

Rigot, V., Lehmann, M., Andre, F., Daemi, N., Marvaldi, J., & Luis, J. (1998). Integrin ligation and PKC activation are required for migration of colon carcinoma cells. Journal of Cell Science, 111(Pt 20), 3119–3127.PubMed

91.

Larsson, C. (2006). Protein kinase C and the regulation of the actin cytoskeleton. Cellular Signalling, 18(3), 276–284.PubMedCrossRef

92.

Disatnik, M. H., & Rando, T. A. (1999). Integrin-mediated muscle cell spreading. The role of protein kinase C in outside-in and inside-out signaling and evidence of integrin cross-talk. Journal of Biological Chemistry, 274(45), 32486–32492.PubMedCrossRef

93.

Rabinovitz, I., Tsomo, L., & Mercurio, A. M. (2004). Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. Molecular and Cellular Biology, 24(10), 4351–4360.PubMedCrossRef

94.

Parsons, M., Keppler, M. D., Kline, A., Messent, A., Humphries, M. J., Gilchrist, R., et al. (2002). Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis. Molecular and Cellular Biology, 22(16), 5897–5911.PubMedCrossRef

95.

Nomura, N., Nomura, M., Sugiyama, K., & Hamada, J. (2007). Src regulates phorbol 12-myristate 13-acetate-activated PKC-induced migration via Cas/Crk/Rac1 signaling pathway in glioblastoma cells. International Journal of Molecular Medicine, 20(4), 511–519.PubMed

96.

Lee, M. S., Kim, Y. B., Lee, S. Y., Kim, J. G., Kim, S. H., Ye, S. K., et al. (2006). Integrin signaling and cell spreading mediated by phorbol 12-myristate 13-acetate treatment. Journal of Cellular Biochemistry, 99(1), 88–95.PubMedCrossRef

97.

De Nichilo, M. O., & Yamada, K. M. (1996). Integrin alpha v beta 5-dependent serine phosphorylation of paxillin in cultured human macrophages adherent to vitronectin. Journal of Biological Chemistry, 271(18), 11016–11022.PubMedCrossRef

98.

Doan, A. T., & Huttenlocher, A. (2007). RACK1 regulates Src activity and modulates paxillin dynamics during cell migration. Experimental Cell Research, 313(12), 2667–2679.PubMedCrossRef

99.

Poli, G., Leonarduzzi, G., Biasi, F., & Chiarpotto, E. (2004). Oxidative stress and cell signalling. Current Medicinal Chemistry, 11(9), 1163–1182.PubMed

100.

Aslan, M., & Ozben, T. (2003). Oxidants in receptor tyrosine kinase signal transduction pathways. Antioxidants & Redox Signalling, 5(6), 781–788.CrossRef

101.

Chiarugi, P. (2005). PTPs versus PTKs: the redox side of the coin. Free Radical Research, 39(4), 353–364.PubMedCrossRef

102.

Giles, G. I. (2006). The redox regulation of thiol dependent signaling pathways in cancer. Current Pharmaceutical Design, 12(34), 4427–4443.PubMedCrossRef

103.

Chandel, N. S., & Budinger, G. R. (2007). The cellular basis for diverse responses to oxygen. Free Radical Biology & Medicine, 42(2), 165–174.CrossRef

104.

Pervaiz, S. (2006). Pro-oxidant milieu blunts scissors: insight into tumor progression, drug resistance, and novel druggable targets. Current Pharmaceutical Design, 12(34), 4469–4477.PubMedCrossRef

105.

Cheng, G. C., Schulze, P. C., Lee, R. T., Sylvan, J., Zetter, B. R., & Huang, H. (2004). Oxidative stress and thioredoxin-interacting protein promote intravasation of melanoma cells. Experimental Cell Research, 300(2), 297–307.PubMedCrossRef

106.

Ferraro, D., Corso, S., Fasano, E., Panieri, E., Santangelo, R., Borrello, S., et al. (2006). Pro-metastatic signaling by c-Met through RAC-1 and reactive oxygen species (ROS). Oncogene, 25(26), 3689–3698.PubMedCrossRef

107.

Park, I. J., Hwang, J. T., Kim, Y. M., Ha, J., & Park, O. J. (2006). Differential modulation of AMPK signaling pathways by low or high levels of exogenous reactive oxygen species in colon cancer cells. Annals of the New York Academy of Sciences, 1091, 102–109.PubMedCrossRef

108.

Jagadeeswaran, R., Jagadeeswaran, S., Bindokas, V. P., & Salgia, R. (2007). Activation of HGF/c-Met pathway contributes to the reactive oxygen species generation and motility of small cell lung cancer cells. American Journal of Physiology Lung Cellular and Molecular Physiology, 292(6), L1488–1494.PubMedCrossRef

109.

Nishigori, C., Hattori, Y., & Toyokuni, S. (2004). Role of reactive oxygen species in skin carcinogenesis. Antioxidants & Redox Signalling, 6(3), 561–570.CrossRef

110.

Miura, D., Miura, Y., & Yagasaki, K. (2004). Resveratrol inhibits hepatoma cell invasion by suppressing gene expression of hepatocyte growth factor via its reactive oxygen species-scavenging property. Clinical & Experimental Metastasis, 21(5), 445–451.CrossRef

111.

Nimnual, A. S., Taylor, L. J., & Bar-Sagi, D. (2003). Redox-dependent downregulation of Rho by Rac. Nature Cell Biology, 5(3), 236–241.PubMedCrossRef

112.

Voncken, J. W., van Schaick, H., Kaartinen, V., Deemer, K., Coates, T., Landing, B., et al. (1995). Increased neutrophil respiratory burst in bcr-null mutants. Cell, 80(5), 719–728.PubMedCrossRef

113.

Bokoch, G. M., & Knaus, U. G. (2003). NADPH oxidases: not just for leukocytes anymore!. Trends in Biochemical Sciences, 28(9), 502–508.PubMedCrossRef

114.

Choi, M. H., Lee, I. K., Kim, G. W., Kim, B. U., Han, Y. H., Yu, D. Y., et al. (2005). Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. Nature, 435(7040), 347–353.PubMedCrossRef

115.

Arakaki, N., Kajihara, T., Arakaki, R., Ohnishi, T., Kazi, J. A., Nakashima, H., et al. (1999). Involvement of oxidative stress in tumor cytotoxic activity of hepatocyte growth factor/scatter factor. Journal of Biological Chemistry, 274(19), 13541–13546.PubMedCrossRef

116.

Colavitti, R., Pani, G., Bedogni, B., Anzevino, R., Borrello, S., Waltenberger, J., et al. (2002). Reactive oxygen species as downstream mediators of angiogenic signaling by vascular endothelial growth factor receptor-2/KDR. Journal of Biological Chemistry, 277(5), 3101–3108.PubMedCrossRef

117.

Werner, E., & Werb, Z. (2002). Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. Journal of Biological Chemistry, 158(2), 357–368.

118.

Kamata, H., Honda, S., Maeda, S., Chang, L., Hirata, H., & Karin, M. (2005). Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell, 120(5), 649–661.PubMedCrossRef

119.

Chen, C. C., Young, J. L., Monzon, R. I., Chen, N., Todorovic, V., & Lau, L. F. (2007). Cytotoxicity of TNFalpha is regulated by integrin-mediated matrix signaling. EMBO Journal, 26(5), 1257–1267.PubMedCrossRef

120.

Chiarugi, P. (2003). Reactive oxygen species as mediators of cell adhesion. Italian Journal of Biochemistry, 52(1), 28–32.PubMed

121.

Chiarugi, P., Pani, G., Giannoni, E., Taddei, L., Colavitti, R., Raugei, G., et al. (2003). Reactive oxygen species as essential mediators of cell adhesion: the oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion. Journal of Cell Biology, 161(5), 933–944.PubMedCrossRef

122.

123.

Meng, T. C., Fukada, T., & Tonks, N. K. (2002). Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Molecular Cell, 9(2), 387–399.PubMedCrossRef

124.

Lee, J. K., Edderkaoui, M., Truong, P., Ohno, I., Jang, K. T., Berti, A., et al. (2007). NADPH oxidase promotes pancreatic cancer cell survival via inhibiting JAK2 dephosphorylation by tyrosine phosphatases. Gastroenterology, 133(5), 1637–1648.PubMedCrossRef

125.

Gozin, A., Franzini, E., Andrieu, V., Da Costa, L., Rollet-Labelle, E., & Pasquier, C. (1998). Reactive oxygen species activate focal adhesion kinase, paxillin and p130cas tyrosine phosphorylation in endothelial cells. Free Radical Biology & Medicine, 25(9), 1021–1032.CrossRef

126.

Ushio-Fukai, M., Tang, Y., Fukai, T., Dikalov, S. I., Ma, Y., Fujimoto, M., et al. (2002). Novel role of gp91(phox) containing NAD(P)H oxidase in vascular endothelial growth factor-induced signaling and angiogenesis. Circulation Research, 91(12), 1160–1167.PubMedCrossRef

127.

Wu, R. F., Xu, Y. C., Ma, Z., Nwariaku, F. E., Sarosi Jr, G. A., & Terada, L. S. (2005). Subcellular targeting of oxidants during endothelial cell migration. Journal of Cell Biology, 171(5), 893–904.PubMedCrossRef

128.

Xu, Y. C., Wu, R. F., Gu, Y., Yang, Y. S., Yang, M. C., Nwariaku, F. E., et al. (2002). Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase. Journal of Biological Chemistry, 277(31), 28051–28057.PubMedCrossRef

129.

Zhang, J., Zhang, L. X., Meltzer, P. S., Barrett, J. C., & Trent, J. M. (2000). Molecular cloning of human Hic-5, a potential regulator involved in signal transduction and cellular senescence. Molecular Carcinogenesis, 27(3), 177–183.PubMedCrossRef

130.

Turner, C. E., Brown, M. C., Perrotta, J. A., Riedy, M. C., Nikolopoulos, S. N., McDonald, A. R., et al. (1999). Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling. Journal of Cell Biology, 145(4), 851–863.PubMedCrossRef

131.

Matsuya, M., Sasaki, H., Aoto, H., Mitaka, T., Nagura, K., Ohba, T., et al. (1998). Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions. Journal of Biological Chemistry, 273(2), 1003–1014.PubMedCrossRef

132.

Nishiya, N., Iwabuchi, Y., Shibanuma, M., Côté, J. F., Tremblay, M. L., & Nose, K. (1999). Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP–PEST) through its LIM 3 domain. Journal of Biological Chemistry, 274(14), 9847–9853.PubMedCrossRef

133.

Lee, K., & Esselman, W. J. (2002). Inhibition of PTPs by H(2)O(2) regulates the activation of distinct MAPK pathways. Free Radical Biology & Medicine, 33(8), 1121–1132.CrossRef

134.

Greene, E. L., Lu, G., Zhang, D., & Egan, B. M. (2001). Signaling events mediating the additive effects of oleic acid and angiotensin II on vascular smooth muscle cell migration. Hypertension, 37(2), 308–312.PubMed

135.

Gopalakrishna, R., & Jaken, S. (2000). Protein kinase C signaling and oxidative stress. Free Radical Biology & Medicine, 28(9), 1349–1361.CrossRef

136.

Shackelford, R. E., Kaufmann, W. K., & Paules, R. S. (2000). Oxidative stress and cell cycle checkpoint function. Free Radical Biology & Medicine, 28(9), 1387–1404.CrossRef

137.

Lin, D., & Takemoto, D. J. (2005). Oxidative activation of protein kinase Cgamma through the C1 domain. Effects on gap junctions. Journal of Biological Chemistry, 280(14), 13682–13693.PubMedCrossRef

138.

Inoguchi, T., Sonta, T., Tsubouchi, H., Etoh, T., Kakimoto, M., Sonoda, N., et al. (2003). Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes: role of vascular NAD(P)H oxidase. Journal of the American Society of Nephrology, 14(8 Suppl 3), S227–232.PubMedCrossRef

139.

Lee, H. B., Yu, M. R., Yang, Y., Jiang, Z., & Ha, H. (2003). Reactive oxygen species-regulated signaling pathways in diabetic nephropathy. Journal of The American Society of Nephrology, 14(8 Suppl 3), S241–245.PubMedCrossRef

140.

Frey, R. S., Gao, X., Javaid, K., Siddiqui, S. S., Rahman, A., & Malik, A. B. (2006). Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells. Journal of Biological Chemistry, 281(23), 16128–16138.PubMedCrossRef

141.

Kwan, J., Wang, H., Munk, S., Xia, L., Goldberg, H. J., & Whiteside, C. I. (2005). In high glucose protein kinase C-zeta activation is required for mesangial cell generation of reactive oxygen species. Kidney International, 68(6), 2526–2541.PubMedCrossRef

142.

Xia, L., Wang, H., Goldberg, H. J., Munk, S., Fantus, I. G., & Whiteside, C. I. (2006). Mesangial cell NADPH oxidase upregulation in high glucose is protein kinase C dependent and required for collagen IV expression. American Journal of Physiology, Renal Physiology, 290(2), F345–356.CrossRef

143.

Talior, I., Tennenbaum, T., Kuroki, T., & Eldar-Finkelman, H. (2005). PKC-delta-dependent activation of oxidative stress in adipocytes of obese and insulin-resistant mice: role for NADPH oxidase. American Journal of Physiology: Endocrinology and Metabolism, 288(2), E405–411.PubMedCrossRef

144.

Lee, H. B., Yu, M. R., Song, J. S., & Ha, H. (2004). Reactive oxygen species amplify protein kinase C signaling in high glucose-induced fibronectin expression by human peritoneal mesothelial cells. Kidney International, 65(4), 1170–1179.PubMedCrossRef

145.

Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S., Tahara, H., Nakayama, K., et al. (2006). Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nature Cell Biology, 8(11), 1291–1297.PubMedCrossRef

146.

Chen, C. C. (1999). Protein kinase C alpha, delta, epsilon and zeta in C6 glioma cells. TPA induces translocation and down-regulation of conventional and new PKC isoforms but not atypical PKC zeta. FEBS Letters, 332(1–2), 169–173.

Titel: Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species
verfasst von: Wen-Sheng Wu
Jia-Ru Wu
Chi-Tan Hu
Publikationsdatum: 01.06.2008
Verlag: Springer US
Erschienen in: Cancer and Metastasis Reviews / Ausgabe 2/2008
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-008-9112-4

Springer Medizin

Signal cross talks for sustained MAPK activation and cell migration: the potential role of reactive oxygen species

Abstract

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2008

Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemias

PRL PTPs: mediators and markers of cancer progression

The tyrosine phosphatase Shp2 (PTPN11) in cancer

Preface

The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer

Targeting PTPs with small molecule inhibitors in cancer treatment

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie