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Journal of Gastrointestinal Cancer

Erschienen in:

18.08.2017 | Review Article

Signaling Pathways as Potential Therapeutic Targets in Hepatocarcinogenesis

verfasst von: Yeliz Yılmaz, Ayşim Güneş, Hande Topel, Neşe Atabey

Erschienen in: Journal of Gastrointestinal Cancer | Ausgabe 3/2017

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Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and has a poor prognosis. HCC is described as a process with a complex molecular pathogenesis. There are three common mechanisms in the initiation of HCC: (i) liver injury, which is induced by etiologic factors such as chronic viral infections with hepatitis B and hepatitis C viruses, alcohol consumption, and obesity; (ii) fibrosis and cirrhosis, which are triggered after recurrent damage and regeneration cycles; and (iii) de-regulation of one or more oncogene and/or tumor suppressor gene [1‐5]. …

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Titel: Signaling Pathways as Potential Therapeutic Targets in Hepatocarcinogenesis
verfasst von: Yeliz Yılmaz
Ayşim Güneş
Hande Topel
Neşe Atabey
Publikationsdatum: 18.08.2017
Verlag: Springer US
Erschienen in: Journal of Gastrointestinal Cancer / Ausgabe 3/2017
Print ISSN: 1941-6628
Elektronische ISSN: 1941-6636
DOI: https://doi.org/10.1007/s12029-017-9958-1

Springer Medizin

Signaling Pathways as Potential Therapeutic Targets in Hepatocarcinogenesis

Excerpt

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Springer Medizin

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