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Forensic Toxicology

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26.07.2016 | Short Communication

Simple regioisomeric differentiation of 2-, 3- and 4-methyl-α-pyrrolidinobutiophenones by gas chromatography–mass spectrometry using bromination

verfasst von: Hiroshi Fujii, Brian Waters, Kenji Hara, Masayuki Kashiwagi, Aya Matsusue, Shin-ichi Kubo

Erschienen in: Forensic Toxicology | Ausgabe 1/2017

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Abstract

A simple method for the differentiation of three cathinone-type regioisomers, 2-, 3- and 4-methyl-α-pyrrolidinobutiophenone (MePBPs), using a bromination procedure was developed in this study. The bromination was performed in a vial where isomers of MePBP, iron(III) bromide, and liquid bromine were added. After excess bromine in the vial was evacuated and an alkaline solution was added, the compounds were extracted with n-hexane and analyzed by gas chromatography–mass spectrometry. This method is a useful way to differentiate among isomers of MePBPs using the differences in the number of peaks generated and the intensity ratio between peaks on the extracted ion chromatograms. This method seems to have great potential to be applied to regioisomer differentiation of other drugs.

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Titel: Simple regioisomeric differentiation of 2-, 3- and 4-methyl-α-pyrrolidinobutiophenones by gas chromatography–mass spectrometry using bromination
verfasst von: Hiroshi Fujii
Brian Waters
Kenji Hara
Masayuki Kashiwagi
Aya Matsusue
Shin-ichi Kubo
Publikationsdatum: 26.07.2016
Verlag: Springer Japan
Erschienen in: Forensic Toxicology / Ausgabe 1/2017
Print ISSN: 1860-8965
Elektronische ISSN: 1860-8973
DOI: https://doi.org/10.1007/s11419-016-0329-6

Neu im Fachgebiet Rechtsmedizin

01.04.2024 | Forensische Traumatologie | CME

Springer Medizin

Simple regioisomeric differentiation of 2-, 3- and 4-methyl-α-pyrrolidinobutiophenones by gas chromatography–mass spectrometry using bromination

Abstract

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