Background
Methods
Integration of MR susceptometry and projection-based velocity quantification
Pulse Sequence
Subjects
Cuff paradigm
Reproducibility
CMR Protocol
Data Analysis
HbO2quantification
Blood velocity quantification
Results
Age (yrs) | Washout (± 2.5 sec) | Upslope (± 0.2%HbO2/sec) | Overshoot (± 3%HbO2) | ΔQmax ± 0.5 | Tff (± 1 sec) | TTP (± 1 sec) |
---|---|---|---|---|---|---|
Old (59 ± 7.3 yrs) | ||||||
58 | 27.5 | 0.49 | 2 | 3.8 | 28 | 20 |
55 | 22.5 | 0.78 | 7 | 10.4 | 25 | 16 |
56 | 12.5 | 1.9 | 7 | 8.3 | 30 | 16 |
55 | 17.5 | 0.9 | 10 | 13.8 | 15 | 14 |
72 | 17.5 | 1.3 | 10 | 5.9 | 26 | 17 |
59.2 ± 7.3
|
19.5 ± 5.7
|
1.07 ± 0.55
|
7.2 ± 3.3
|
8.44 ± 3.9
|
24.8 ± 5.8
|
16.6 ± 2.2
|
Young (26 ± 1.6 yrs) | ||||||
25 | 17.5 | 1.2 | 13 | 9.2 | 22 | 14 |
26 | 17.5 | 1.8 | 25 | 12 | 25 | 14 |
26 | 12.5 | 1.8 | 30 | 12.5 | 30 | 11 |
25 | 12.5 | 1.9 | 25 | 7.7 | 20 | 11 |
29 | 12.5 | 1.9 | 20 | 6.65 | 25 | 14 |
26.2 ± 1.6
|
14.5 ± 2.7
|
1.72 ± 0.29
|
22.6 ± 6.4
|
9.61 ± 2.6
|
24.4 ± 3.8
|
12.8 ± 1.64
|
*p-value
|
0.127
|
0.058
|
0.003
|
0.592
|
0.9
|
0.017
|
Washout (sec) | Upslope (HbO2/sec) | Overshoot (HbO2) | Tff (sec) | TTP (sec) | vpeak, avg (cm/s) | |
---|---|---|---|---|---|---|
Healthy 39 yr-old | ||||||
Exp 1 | 15 | 2 | 30 | 19 | 10 | 13.5 |
Exp 2 | 12.5 | 1.9 | 32 | 15 | 9 | 13.6 |
Exp 3 | 12.5 | 2.2 | 30 | 17 | 9 | 12.5 |
Avg | 13.3 | 2.0 | 30.7 | 17 | 9.3 | 13.2 |
Std | 1.4 | 0.15 | 1.15 | 2 | 0.58 | 0.61 |
CV (%) | 10.5 | 7.5 | 3.7 | 11.8 | 6.2 | 4.6 |
Healthy 26 yr-old
| ||||||
Exp 1 | 22.5 | 1.32 | 11 | 10 | 4.1 | 20.6 |
Exp 2 | 22.5 | 1.29 | 8 | 12 | 4.4 | 24.6 |
Exp 3 | 22.5 | 1.54 | 10 | 12 | 4 | 25.4 |
Avg | 22.5 | 1.38 | 9.7 | 11.3 | 4.17 | 23.5 |
Std | 0 | 0.136 | 1.53 | 1.15 | 0.21 | 2.57 |
CV (%) | 0 | 9.9 | 15.8 | 10.2 | 5.0 | 10.9 |