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Erschienen in:
01.06.2018 | Research Article
Single-breath-hold abdominal \({T}_{1}\) mapping using 3D Cartesian Look-Locker with spatiotemporal sparsity constraints
Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine | Ausgabe 3/2018
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Objective
Our aim was to develop and validate a 3D Cartesian Look-Locker \({T}_{1}\) mapping technique that achieves high accuracy and whole-liver coverage within a single breath-hold.
Materials and methods
The proposed method combines sparse Cartesian sampling based on a spatiotemporally incoherent Poisson pattern and k-space segmentation, dedicated for high-temporal-resolution imaging. This combination allows capturing tissue with short relaxation times with volumetric coverage. A joint reconstruction of the 3D + inversion time (TI) data via compressed sensing exploits the spatiotemporal sparsity and ensures consistent quality for the subsequent multistep \({T}_{1}\) mapping. Data from the National Institute of Standards and Technology (NIST) phantom and 11 volunteers, along with reference 2D Look-Locker acquisitions, are used for validation. 2D and 3D methods are compared based on \({T}_{1}\) values in different abdominal tissues at 1.5 and 3 T.
Results
\({T}_{1}\) maps obtained from the proposed 3D method compare favorably with those from the 2D reference and additionally allow for reformatting or volumetric analysis. Excellent agreement is shown in phantom [bias\(_{3{\mathrm{T}}}\) < 2%, bias\(_{1.5{\mathrm{T}}}\) < 5% for (120; 2000) ms] and volunteer data (3D and 2D deviation < 4% for liver, muscle, and spleen) for clinically acceptable scan (20 s) and reconstruction times (< 4 min).
Conclusion
Whole-liver \({T}_{1}\) mapping with high accuracy and precision is feasible in one breath-hold using spatiotemporally incoherent, sparse 3D Cartesian sampling.