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Magnetic Resonance Materials in Physics, Biology and Medicine

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01.06.2018 | Research Article

Arterial input function in a dedicated slice for cerebral perfusion measurements in humans

verfasst von: Elias Kellner, Irina Mader, Marco Reisert, Horst Urbach, Valerij Gennadevic Kiselev

Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine | Ausgabe 3/2018

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Abstract

Object

We aimed to modify our previously published method for arterial input function measurements for evaluation of cerebral perfusion (dynamic susceptibility contrast MRI) such that it can be applied in humans in a clinical setting.

Materials and methods

Similarly to our previous work, a conventional measurement sequence for dynamic susceptibility contrast MRI is extended with an additional measurement slice at the neck. Measurement parameters at this slice were optimized for the blood signal (short echo time, background suppression, magnitude and phase images). Phase-based evaluation of the signal in the carotid arteries is used to obtain quantitative arterial input functions.

Results

In all pilot measurements, quantitative arterial input functions were obtained. The resulting absolute perfusion parameters agree well with literature values (gray and white matter mean values of 46 and 24 mL/100 g/min, respectively, for cerebral blood flow and 3.0% and 1.6%, respectively, for cerebral blood volume).

Conclusions

The proposed method has the potential to quantify arterial input functions in the carotid arteries from a direct measurement without any additional normalization.

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Titel: Arterial input function in a dedicated slice for cerebral perfusion measurements in humans
verfasst von: Elias Kellner
Irina Mader
Marco Reisert
Horst Urbach
Valerij Gennadevic Kiselev
Publikationsdatum: 01.06.2018
Verlag: Springer International Publishing
Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine / Ausgabe 3/2018
Print ISSN: 0968-5243
Elektronische ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-017-0663-7

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