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Journal of Assisted Reproduction and Genetics

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01.08.2011 | Genetics

Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest

verfasst von: Toshinobu Miyamoto, Akira Tsujimura, Yasushi Miyagawa, Eitetsu Koh, Mikio Namiki, Michiharu Horikawa, Yasuaki Saijo, Kazuo Sengoku

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 8/2011

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Abstract

Purpose

To investigate the association between the UBR2 gene and the risk of azoospermia caused by meiotic arrest.

Methods

Mutational analysis of the UBR2 gene was performed using DNA from 30 patients with azoospermia by meiotic arrest to 80 normal controls.

Results

The genotypic and allelic frequencies of c.1,066A>T variant were significantly higher in patient than control groups (p < 0.001).

Conclusion

The c.1,066A>T variant in the UBR2 gene is associated with increased susceptibility to azoospermia caused by meiotic arrest.

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Titel: Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest
verfasst von: Toshinobu Miyamoto
Akira Tsujimura
Yasushi Miyagawa
Eitetsu Koh
Mikio Namiki
Michiharu Horikawa
Yasuaki Saijo
Kazuo Sengoku
Publikationsdatum: 01.08.2011
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 8/2011
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-011-9576-y

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Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest