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Seminars in Immunopathology

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01.06.2010 | Review

SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions

verfasst von: Cynthia Detre, Marton Keszei, Xavier Romero, George C. Tsokos, Cox Terhorst

Erschienen in: Seminars in Immunopathology | Ausgabe 2/2010

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Abstract

One or more of the signaling lymphocytic activation molecule (SLAM) family (SLAMF) of cell surface receptors, which consists of nine transmembrane proteins, i.e., SLAMF1-9, are expressed on most hematopoietic cells. While most SLAMF receptors serve as self-ligands, SLAMF2 and SLAMF4 use each other as counter structures. Six of the receptors carry one or more copies of a unique intracellular tyrosine-based switch motif, which has high affinity for the single SH2-domain signaling molecules SLAM-associated protein and EAT-2. Whereas SLAMF receptors are costimulatory molecules on the surface of CD4+, CD8+, and natural killer (NK) T cells, they also involved in early phases of lineage commitment during hematopoiesis. SLAMF receptors regulate T lymphocyte development and function and modulate lytic activity, cytokine production, and major histocompatibility complex-independent cell inhibition of NK cells. Furthermore, they modulate B cell activation and memory generation, neutrophil, dendritic cell, macrophage and eosinophil function, and platelet aggregation. In this review, we will discuss the role of SLAM receptors and their adapters in T cell function, and we will examine the role of these receptors and their adapters in X-linked lymphoproliferative disease and their contribution to disease susceptibility in systemic lupus erythematosus.

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Titel: SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions
verfasst von: Cynthia Detre
Marton Keszei
Xavier Romero
George C. Tsokos
Cox Terhorst
Publikationsdatum: 01.06.2010
Verlag: Springer-Verlag
Erschienen in: Seminars in Immunopathology / Ausgabe 2/2010
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-009-0193-0

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SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions

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