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Current Sleep Medicine Reports

06.02.2024 | Review

Sleep Disorders and Challenges in People Living with Human Immunodeficiency Virus: A Narrative Literature Review

verfasst von: Lourdes M. DelRosso, Deacon Yang, Muhammad S. Khan, Maria P. Mogavero, Giovanni Schifitto, Raffaele Ferri

Erschienen in: Current Sleep Medicine Reports

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Abstract

Purpose of Review

Understanding the prevalence, presentation, and outcomes of the contribution of sleep disorders to sleep disruption and quality of life of persons living with human immunodeficiency virus (HIV) infection (PLWH) is crucial for planning comprehensive patient care and management strategies. This review focuses on the presence of sleep disorders in PLWH and identifies possible challenges and treatment options.

Recent Findings

The prevalence of insomnia among PLWH is significantly higher than in the general population (29–97%), due to complex and multifactorial mechanisms. A multidisciplinary approach that incorporates behavioral therapies and, when appropriate, pharmacological interventions, while closely monitoring for potential drug interactions, should be carried out. Men with HIV may have an increased frequency of sleep disordered breathing, possibly associated to inflammatory markers which can be counteracted by adequate ventilation at night. Also, restless legs syndrome (RLS) seems to be frequent in PLWH with a possible main involvement of iron metabolism and dopaminergic dysfunction. HIV directly affects the suprachiasmatic nucleus, with the potential contribution of specific genetic factors, potentially resulting in circadian rhythm sleep-wake disorders. Also, narcolepsy might be hypothesized to be favored by HIV infection.

Summary

Sleep disorders, such as insomnia, OSA, and RLS are common in PLWH, but other less common disorders, such as narcolepsy and circadian rhythm sleep-wake disorders, can also be present. Although there is literature on the complexity of the pathophysiology in these disorders, evidence is lacking on the effectiveness of treatment options and on the specific effects of sleep disorders in all populations affected by HIV.
Literatur
1.
Pham QD, Wilson DP, Law MG, Kelleher AD, Zhang L. Global burden of transmitted HIV drug resistance and HIV-exposure categories: a systematic review and meta-analysis. AIDS. 2014;28(18):2751–62.PubMedCrossRef
2.
Vermund SH, Narayan KM, Glass RI. Chronic diseases in HIV survivors. Sci Transl Med. 2014;6(241):241ed14.PubMedCrossRef
3.
Sax PE, Erlandson KM, Lake JE, McComsey GA, Orkin C, Esser S, et al. Weight gain following initiation of antiretroviral therapy: risk factors in randomized comparative clinical trials. Clin Infect Dis. 2020;71(6):1379–89.PubMedCrossRef
4.
5.
6.
van de Langenberg SCN, Kocevska D, Luik AI. The multidimensionality of sleep in population-based samples: a narrative review. J Sleep Res. 2022;31(4):e13608.PubMedPubMedCentralCrossRef
7.
Appleton SL, Gill TK, Lang CJ, Taylor AW, McEvoy RD, Stocks NP, et al. Prevalence and comorbidity of sleep conditions in Australian adults: 2016 Sleep Health Foundation national survey. Sleep Health. 2018;4(1):13–9.PubMedCrossRef
8.
O'Brien KE, Riddell NE, Gomez-Olive FX, Rae DE, Scheuermaier K, von Schantz M. Sleep disturbances in HIV infection and their biological basis. Sleep Med Rev. 2022;65:101571.PubMedCrossRef
9.
Polanka BM, Kundu S, So-Armah KA, Freiberg MS, Gupta SK, Bedimo RJ, et al. Insomnia as an independent predictor of incident cardiovascular disease in HIV: data from the Veterans Aging Cohort Study. J Acquir Immune Defic Syndr. 2019;81(1):110–7.PubMedPubMedCentralCrossRef
10.
Seay JS, McIntosh R, Fekete EM, Fletcher MA, Kumar M, Schneiderman N, et al. Self-reported sleep disturbance is associated with lower CD4 count and 24-h urinary dopamine levels in ethnic minority women living with HIV. Psychoneuroendocrinology. 2013;38(11):2647–53.PubMedCrossRef
11.
Pujasari H, Chung MH. Sleep disturbance in the context of HIV: a concept analysis. SAGE Open Nurs. 2022;8:23779608221094541.PubMedPubMedCentral
12.
Ruiz P, Guynn RW, Matorin AA. Psychiatric considerations in the diagnosis, treatment, and prevention of HIV/AIDS. J Psychiatr Pract. 2000;6(3):129–39.PubMedCrossRef
13.
Cody SL, Hobson JM, Gilstrap SR, Thomas SJ, Galinat D, Goodin BR. Sleep disturbances and chronic pain in people with HIV: implications for HIV-associated neurocognitive disorders. Curr Sleep Med Rep. 2022;8(4):124–31.PubMedPubMedCentralCrossRef
14.
Davis S. Clinical sequelae affecting quality of life in the HIV-infected patient. J Assoc Nurses AIDS Care. 2004;15(5 Suppl):28S–33S.PubMedCrossRef
15.
Vosvick M, Gore-Felton C, Ashton E, Koopman C, Fluery T, Israelski D, et al. Sleep disturbances among HIV-positive adults: the role of pain, stress, and social support. J Psychosom Res. 2004;57(5):459–63.PubMed
16.
Kenedi CA, Goforth HW. A systematic review of the psychiatric side-effects of efavirenz. AIDS Behav. 2011;15(8):1803–18.PubMedCrossRef
17.
Low Y, Goforth H, Preud'homme X, Edinger J, Krystal A. Insomnia in HIV-infected patients: pathophysiologic implications. AIDS Rev. 2014;16(1):3–13.PubMed
18.
Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193–213.PubMedCrossRef
19.
American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington, VA: American Psychiatric Publishing; 2013.CrossRef
20.
American Academy of Sleep Medicine. In: Sateia M, editor. International classification of sleep disorders. 3rd ed. Darien, IL: American Academy of Sleep Medicine; 2014.
21.
American Academy of Sleep Medicine. International Classification of Sleep Disorders. 3rd ed. Darien, IL: American Academy of Sleep Medicine; 2023.
22.
Gutierrez J, Tedaldi EM, Armon C, Patel V, Hart R, Buchacz K. Sleep disturbances in HIV-infected patients associated with depression and high risk of obstructive sleep apnea. SAGE Open Med. 2019;7:2050312119842268.PubMedPubMedCentralCrossRef
23.
Mazzitelli M, Trunfio M, Milinkovic A, Castelli E, Sasset L, Leoni D, et al. Sleep disturbances and their correlation with cardiovascular risk, obesity, and mood disorders in people with HIV. Aids. 2023;37(6):925–34.PubMedCrossRef
24.
Lee KA, Gay C, Byun E, Lerdal A, Pullinger CR, Aouizerat BE. Circadian regulation gene polymorphisms are associated with sleep disruption and duration, and circadian phase and rhythm in adults with HIV. Chronobiol Int. 2015;32(9):1278–93.PubMedPubMedCentralCrossRef
25.
26.
27.
Gallego L, Barreiro P, del Rio R, Gonzalez de Requena D, Rodriguez-Albarino A, Gonzalez-Lahoz J, et al. Analyzing sleep abnormalities in HIV-infected patients treated with Efavirenz. Clin Infect Dis. 2004;38(3):430–2.PubMedCrossRef
28.
Riemann D, Benz F, Dressle RJ, Espie CA, Johann AF, Blanken TF, et al. Insomnia disorder: state of the science and challenges for the future. J Sleep Res. 2022;31(4):e13604.PubMedCrossRef
29.
Smith MT, Huang MI, Manber R. Cognitive behavior therapy for chronic insomnia occurring within the context of medical and psychiatric disorders. Clin Psychol Rev. 2005;25(5):559–92.PubMedCrossRef
30.
Meng J, Zheng C, Wang H, Valimaki M, Wang M. Non-pharmacological interventions for improving sleep in people living with HIV: a systematic narrative review. Front Neurol. 2023;14:1017896.PubMedPubMedCentralCrossRef
31.
Webel AR, Moore SM, Hanson JE, Patel SR, Schmotzer B, Salata RA. Improving sleep hygiene behavior in adults living with HIV/AIDS: a randomized control pilot study of the SystemCHANGE(TM)-HIV intervention. Appl Nurs Res. 2013;26(2):85–91.PubMedCrossRef
32.
Hudson AL, Portillo CJ, Lee KA. Sleep disturbances in women with HIV or AIDS: efficacy of a tailored sleep promotion intervention. Nurs Res. 2008;57(5):360–6.PubMedCrossRef
33.
Goldschmied JR, Sengupta A, Sharma A, Taylor L, Morales KH, Thase ME, et al. Treatment of insomnia with zaleplon in HIV+ significantly improves sleep and depression. Psychopharmacol Bull. 2021;51(3):50–64.PubMedPubMedCentral
34.
Ranzani A, Oreni L, Agro M, van den Bogaart L, Milazzo L, Giacomelli A, et al. Burden of exposure to potential interactions between antiretroviral and non-antiretroviral medications in a population of HIV-positive patients aged 50 years or older. J Acquir Immune Defic Syndr. 2018;78(2):193–201.PubMedCrossRef
35.
Omonuwa TS, Goforth HW, Preud'homme X, Krystal AD. The pharmacologic management of insomnia in patients with HIV. J Clin Sleep Med. 2009;5(3):251–62.PubMedPubMedCentralCrossRef
36.
Troester MM, Quan SF, Berry RR, Plante DT, Abreu AR, Alzoubaidi M, et al. The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications. Version 3. American Academy of Sleep Medicine: Darien, IL; 2023.
37.
DelRosso LM, Mogavero MP, Ferri R. Effect of sleep disorders on blood pressure and hypertension in children. Curr Hypertens Rep. 2020;22(11):88.PubMedCrossRef
38.
Rajachandran M, Nickel N, Lange RA. Sleep apnea and cardiovascular risk. Curr Opin Cardiol. 2023;38(5):456–61.PubMedCrossRef
39.
Chen CC, Lin CY, Chen YC, Ko WC, Li CY, Ko NY. High sleep-related breathing disorders among HIV-infected patients with sleep complaints. Sleep Med. 2020;75:218–24.PubMedCrossRef
40.
Chen YC, Lin CY, Li CY, Zhang Y, Ko WC, Ko NY. Obstructive sleep apnea among HIV-infected men in the highly active antiretroviral therapy era: a nation-wide longitudinal cohort study in Taiwan, 2000-2011. Sleep Med. 2020;65:89–95.PubMedCrossRef
41.
Massongo M, Ngarka L, Balkissou DA, Poka-Mayap V, Sonwa SV, Tatah GY, et al. Sleep apnea syndrome: prevalence and comorbidity with other non-communicable diseases and HIV infection, among hospitalized patients in Yaounde, Cameroon. Sleep Disord. 2022;2022:4359294.PubMedPubMedCentralCrossRef
42.
Abdeen Y, Al-Halawani M, Kaako A, Hao IFY, Dazley J, Katpally R, et al. Effect of the duration of protease inhibitor therapy in HIV-infected individuals on the severity of obstructive sleep apnea. J Res Med Sci. 2019;24:65.PubMedPubMedCentralCrossRef
43.
Asgari S, Najafi A, Sadeghniiat K, Gholamypour Z, Akbarpour S. The association between body mass index and risk of obstructive sleep apnea among patients with HIV. J Res Med Sci. 2021;26:123.PubMedPubMedCentralCrossRef
44.
Orr JE, Edwards BA, Schmickl CN, Karris M, DeYoung PN, Darquenne C, et al. Pathogenesis of obstructive sleep apnea in people living with HIV. J Appl Physiol. 2021;131(6):1671–8.PubMedPubMedCentralCrossRef
45.
Karamanli H, Ozol D, Ugur KS, Yildirim Z, Armutcu F, Bozkurt B, et al. Influence of CPAP treatment on airway and systemic inflammation in OSAS patients. Sleep Breath. 2014;18(2):251–6.PubMedCrossRef
46.
47.
Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, et al. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria--history, rationale, description, and significance. Sleep Med. 2014;15(8):860–73.PubMedCrossRef
48.
DelRosso LM, Mogavero MP, Baroni A, Bruni O, Ferri R. Restless legs syndrome in children and adolescents. Child Adolesc Psychiatr Clin N Am. 2021;30(1):143–57.PubMedCrossRef
49.
DelRosso LM, Mogavero MP, Ferri R. Restless sleep disorder, restless legs syndrome, and periodic limb movement disorder-sleep in motion! Pediatr Pulmonol. 2022;57(8):1879–86.PubMedCrossRef
50.
DelRosso LM, Ferri R, Chen ML, Kapoor V, Allen RP, Mogavero MP, et al. Clinical efficacy and safety of intravenous ferric carboxymaltose treatment of pediatric restless legs syndrome and periodic limb movement disorder. Sleep Med. 2021;87:114–8.PubMedCrossRef
51.
Mogavero MP, Mezzapesa DM, Savarese M, DelRosso LM, Lanza G, Ferri R. Morphological analysis of the brain subcortical gray structures in restless legs syndrome. Sleep Med. 2021;88:74–80.PubMedCrossRef
52.
Manconi M, Garcia-Borreguero D, Schormair B, Videnovic A, Berger K, Ferri R, et al. Restless legs syndrome. Nat Rev Dis Primers. 2021;7(1):80.PubMedCrossRef
53.
Ferri R, Mogavero MP, Bruni O, Picchietti DL, DelRosso LM. Periodic leg movements during sleep associated with antidepressants: a meta-analysis. Neurosci Biobehav Rev. 2023;148:105126.PubMedCrossRef
54.
Ferri R, Mogavero MP, Bruni O, Picchietti DL, Kapoor V, DelRosso LM. Leg movements during sleep in children treated with serotonergic antidepressants. Sleep. 2022;45(3):zsab236.PubMedCrossRef
55.
Murray KD, Tivarus ME, Schifitto G, Uddin MN, Zhong J. Brain iron imaging markers in the presence of white matter hyperintensities. Magn Reson Imaging. 2023;98:115–23.PubMedPubMedCentralCrossRef
56.
Happe S, Kundmuller L, Reichelt D, Husstedt IW, Evers S. Comorbidity of restless legs syndrome and HIV infection. J Neurol. 2007;254(10):1401–6.PubMedCrossRef
57.
Wallace DM, Alcaide ML, Wohlgemuth WK, Jones Weiss DL, Uribe Starita C, Patel SR, et al. Prevalence and correlates of restless legs syndrome in men living with HIV. PLoS One. 2021;16(10):e0258139.PubMedPubMedCentralCrossRef
58.
Kunisaki KM, De Francesco D, Sabin CA, Winston A, Mallon PWG, Anderson J, et al. Sleep disorders in human immunodeficiency virus: a substudy of the pharmacokinetics and clinical observations in People Over Fifty (POPPY) Study. Open Forum Infect Dis. 2021;8(1):ofaa561.PubMedCrossRef
59.
Hennessy MD, Zak RS, Gay CL, Pullinger CR, Lee KA, Aouizerat BE. Polymorphisms of interleukin-1 beta and interleukin-17Alpha genes are associated with restless legs syndrome. Biol Res Nurs. 2014;16(2):143–51.PubMedCrossRef
60.
Safarpour Y, Vaziri ND, Jabbari B. Restless legs syndrome in chronic kidney disease- a systematic review. Tremor Other Hyperkinet Mov. 2023;13:10.CrossRef
61.
Cardoso F. HIV-related movement disorders: epidemiology, pathogenesis and management. CNS Drugs. 2002;16(10):663–8.PubMedCrossRef
62.
Lopez-Calderon C, Palacios R, Cobo A, Nuno E, Ruiz J, Marquez M, et al. Serum ferritin in HIV-positive patients is related to immune deficiency and inflammatory activity. Int J STD AIDS. 2015;26(6):393–7.PubMedCrossRef
63.
Ameglio F, Tilocca F, Arca MV, Alemanno L, Dolei A. Ferritin downregulation in HIV-infected cells. AIDS Res Hum Retroviruses. 1993;9(8):795–8.PubMedCrossRef
64.
Harrison EG, Keating JL, Morgan PE. Non-pharmacological interventions for restless legs syndrome: a systematic review of randomised controlled trials. Disabil Rehabil. 2019;41(17):2006–14.PubMedCrossRef
65.
Attal N, Cruccu G, Baron R, Haanpaa M, Hansson P, Jensen TS, et al. EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur J Neurol. 2010;17(9):1113–e88.PubMedCrossRef
66.
Ahmadi-Motamayel F, Vaziri-Amjad S, Goodarzi MT, Samie L, Poorolajal J. Evaluation of salivary melatonin levels in HIV-positive patients: a historical cohort study. Rev Recent Clin Trials. 2017;12(3):168–73.PubMedCrossRef
67.
Redman KN, O'Brien KE, Ruiz FS, Rae DE, Gomez-Olive FX, von Schantz M, et al. Delayed circadian rhythms in older Africans living with human immunodeficiency virus (HIV). J Pineal Res. 2023;74(1):e12838.PubMedCrossRef
68.
Wang T, Jiang Z, Hou W, Li Z, Cheng S, Green LA, et al. HIV Tat protein affects circadian rhythmicity by interfering with the circadian system. HIV Med. 2014;15(9):565–70.PubMedPubMedCentralCrossRef
69.
Gunthard HF, Calvez V, Paredes R, Pillay D, Shafer RW, Wensing AM, et al. Human Immunodeficiency virus drug resistance: 2018 recommendations of the International Antiviral Society-USA Panel. Clin Infect Dis. 2019;68(2):177–87.PubMedCrossRef
70.
Auger RR, Burgess HJ, Emens JS, Deriy LV, Thomas SM, Sharkey KM. Clinical practice guideline for the treatment of intrinsic circadian rhythm sleep-wake disorders: advanced sleep-wake phase disorder (ASWPD), delayed sleep-wake phase disorder (DSWPD), non-24-hour sleep-wake rhythm disorder (N24SWD), and irregular sleep-wake rhythm disorder (ISWRD). An update for 2015: an American academy of sleep medicine clinical practice guideline. J Clin Sleep Med. 2015;11(10):1199–236.PubMedPubMedCentralCrossRef
71.
Scherrer KS, Relly C, Hackenberg A, Berger C, Paioni P. Case report: narcolepsy type 1 in an adolescent with HIV infection-coincidence or potential trigger? Medicine. 2018;97(30):e11490.PubMedPubMedCentralCrossRef
72.
Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, et al. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains 124. NatMed. 2000;6(9):991–7.
73.
74.
Venkataraman A, Zhuang Y, Marsella J, Tivarus ME, Qiu X, Wang L, et al. Functional MRI correlates of sleep quality in HIV. Nat Sci Sleep. 2021;13:291–301.PubMedPubMedCentralCrossRef
75.
Vera JH, Guo Q, Cole JH, Boasso A, Greathead L, Kelleher P, et al. Neuroinflammation in treated HIV-positive individuals: a TSPO PET study. Neurology. 2016;86(15):1425–32.PubMedPubMedCentralCrossRef
76.
77.
Nickoloff-Bybel EA, Calderon TM, Gaskill PJ, Berman JW. HIV Neuropathogenesis in the presence of a disrupted dopamine system. J Neuroimmune Pharmacol. 2020;15(4):729–42.PubMedPubMedCentralCrossRef
78.
Minoguchi K, Tazaki T, Yokoe T, Minoguchi H, Watanabe Y, Yamamoto M, et al. Elevated production of tumor necrosis factor-alpha by monocytes in patients with obstructive sleep apnea syndrome. Chest. 2004;126(5):1473–9.PubMedCrossRef
79.
Vgontzas AN, Zoumakis E, Lin HM, Bixler EO, Trakada G, Chrousos GP. Marked decrease in sleepiness in patients with sleep apnea by etanercept, a tumor necrosis factor-alpha antagonist. J Clin Endocrinol Metab. 2004;89(9):4409–13.PubMedCrossRef
80.
Johnston CD, O'Brien R, Cote HCF. Inclusion of women in HIV research and clinical trials. AIDS. 2023;37(6):995–7.PubMedCrossRef
Metadaten
Titel
Sleep Disorders and Challenges in People Living with Human Immunodeficiency Virus: A Narrative Literature Review
verfasst von
Lourdes M. DelRosso
Deacon Yang
Muhammad S. Khan
Maria P. Mogavero
Giovanni Schifitto
Raffaele Ferri
Publikationsdatum
06.02.2024
Verlag
Springer International Publishing
Erschienen in
Current Sleep Medicine Reports
Elektronische ISSN: 2198-6401
DOI
https://doi.org/10.1007/s40675-024-00283-y

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