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Head and Neck Pathology

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01.03.2014 | Case Report

Small Cell Neuroendocrine Carcinoma of the Oropharynx Harbouring Oncogenic HPV-Infection

verfasst von: Timothy Bates, Andrew McQueen, Muhammad Shahid Iqbal, Charles Kelly, Max Robinson

Erschienen in: Head and Neck Pathology | Ausgabe 1/2014

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Abstract

Small cell carcinoma/neuroendocrine carcinoma (SCNEC) of the oropharynx is uncommon. Recently, an association has been reported between oropharyngeal SCNEC and high-risk human papillomavirus (HPV) infection. While HPV infection confers a better prognosis for oropharyngeal squamous cell carcinoma, HPV infection does not appear to influence the biological behaviour of SCNECs, which are generally associated with poor clinical outcomes. We document two cases of SCNEC arising in the oropharynx with evidence of high-risk HPV infection. The cases highlight the expanding range of malignant oropharyngeal neoplasms that harbour oncogenic HPV infection and support the concept that, irrespective of HPV infection, neuroendocrine differentiation portends a poor prognosis.

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Titel: Small Cell Neuroendocrine Carcinoma of the Oropharynx Harbouring Oncogenic HPV-Infection
verfasst von: Timothy Bates
Andrew McQueen
Muhammad Shahid Iqbal
Charles Kelly
Max Robinson
Publikationsdatum: 01.03.2014
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 1/2014
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-013-0471-y

Springer Medizin

Small Cell Neuroendocrine Carcinoma of the Oropharynx Harbouring Oncogenic HPV-Infection

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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