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Breast Cancer Research and Treatment

Ausgabe 1/2012

Inhalt (36 Artikel)

Review

Is knowledge translation adequate? A quality assurance study of staging investigations in early stage breast cancer patients

Dolly Han, Sophie Hogeveen, Miriam Sweet Goldstein, Ralph George, Christine Brezden-Masley, Jeffrey Hoch, Rashida Haq, Christine E. Simmons

Review

Bloody nipple discharge is a predictor of breast cancer risk: a meta-analysis

Ling Chen, Wen-Bin Zhou, Yi Zhao, Xiao-An Liu, Qiang Ding, Xiao-Ming Zha, Shui Wang

Preclinical study

Genomic profiling of mitochondrion-rich breast carcinoma: chromosomal changes may be relevant for mitochondria accumulation and tumour biology

Felipe C. Geyer, Dario de Biase, Maryou B. K. Lambros, Moira Ragazzi, Maria A. Lopez-Garcia, Rachael Natrajan, Alan Mackay, Ivana Kurelac, Giuseppe Gasparre, Alan Ashworth, Vincenzo Eusebi, Jorge S. Reis-Filho, Giovanni Tallini

Preclinical study

Mutational characterization of individual breast tumors: TP53 and PI3K pathway genes are frequently and distinctively mutated in different subtypes

Sandrine Boyault, Youenn Drouet, Claudine Navarro, Thomas Bachelot, Christine Lasset, Isabelle Treilleux, Eric Tabone, Alain Puisieux, Qing Wang

Preclinical study

Digital image analysis of membrane connectivity is a robust measure of HER2 immunostains

Anja Brügmann, Mikkel Eld, Giedrius Lelkaitis, Søren Nielsen, Michael Grunkin, Johan D. Hansen, Niels T. Foged, Mogens Vyberg

Preclinical study

COX2 overexpression is a prognostic marker for Stage III breast cancer

Hee Sung Kim, Hyeong-Gon Moon, Wonshik Han, Cha Kyung Yom, Woo Ho Kim, Jun Ho Kim, Dong-Young Noh

Preclinical study

Estrogen and insulin-like growth factor-I (IGF-I) independently down-regulate critical repressors of breast cancer growth

Angelo J. Casa, Adam S. Potter, Simeen Malik, ZaWaunyka Lazard, Isere Kuiatse, Hee-Tae Kim, Anna Tsimelzon, Chad J. Creighton, Susan G. Hilsenbeck, Powell H. Brown, Steffi Oesterreich, Adrian V. Lee

Preclinical study

Prolonged mammosphere culture of MCF-7 cells induces an EMT and repression of the estrogen receptor by microRNAs

I. K. Guttilla, K. N. Phoenix, X. Hong, J. S. Tirnauer, K. P. Claffey, B. A. White

Preclinical study

Prevalence of BRCA1/2 mutations in sporadic breast/ovarian cancer patients and identification of a novel de novo BRCA1 mutation in a patient diagnosed with late onset breast and ovarian cancer: implications for genetic testing

Kim De Leeneer, Ilse Coene, Brecht Crombez, Justine Simkens, Rudy Van den Broecke, Alain Bols, Barbara Stragier, Ilse Vanhoutte, Anne De Paepe, Bruce Poppe, Kathleen Claes

Preclinical study

Overexpression of ligase defective E6-associated protein, E6-AP, results in mammary tumorigenesis

Sivapriya Ramamoorthy, Rozina Tufail, Jimmy El Hokayem, Mercy Jorda, Wei Zhao, Zizi Reis, Zafar Nawaz

Preclinical study

ErbB1/2 tyrosine kinase inhibitor mediates oxidative stress-induced apoptosis in inflammatory breast cancer cells

Katherine M. Aird, Jennifer L. Allensworth, Ines Batinic-Haberle, H. Kim Lyerly, Mark W. Dewhirst, Gayathri R. Devi

Preclinical study

The influence of removal of primary tumor on incidence and phenotype of circulating tumor cells in primary breast cancer

Malgorzata Banys, Natalia Krawczyk, Sven Becker, Jolanta Jakubowska, Annette Staebler, Diethelm Wallwiener, Tanja Fehm, Ralf Rothmund

Preclinical Study

Insulin-like growth factor receptor (IGF-1R) in breast cancer subtypes

Rinat Yerushalmi, Karen A. Gelmon, Samuel Leung, Dongxia Gao, Maggie Cheang, Michael Pollak, Gulisa Turashvili, Blakes C. Gilks, Hagen Kennecke

Preclinical study

Keratin 15, transcobalamin I and homeobox gene Hox-B13 expression in breast phyllodes tumors: novel markers in biological classification

Luke Yong-Zheng Chong, Poh Yian Cheok, Wai-Jin Tan, Aye Aye Thike, George Allen, Mei Kim Ang, Aik Seng Ooi, Patrick Tan, Bin Tean Teh, Puay Hoon Tan

Preclinical Study

Mesenchymal stem cells from primary breast cancer tissue promote cancer proliferation and enhance mammosphere formation partially via EGF/EGFR/Akt pathway

Xin-long Yan, Chun-jiang Fu, Lin Chen, Jin-hua Qin, Quan Zeng, Hong-feng Yuan, Xue Nan, Hai-xu Chen, Jun-nian Zhou, Yan-li Lin, Xiao-mei Zhang, Cheng-ze Yu, Wen Yue, Xue-tao Pei

Preclinical Study

Detection of aberrant promoter methylation of GSTP1, RASSF1A, and RARβ2 in serum DNA of patients with breast cancer by a newly established one-step methylation-specific PCR assay

Noriaki Yamamoto, Takahiro Nakayama, Masahiro Kajita, Tomohiro Miyake, Takashi Iwamoto, Seung Jin Kim, Ayako Sakai, Hideki Ishihara, Yasuhiro Tamaki, Shinzaburo Noguchi

Preclinical Study

Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles

Abena S. Agyeman, Raghothama Chaerkady, Patrick G. Shaw, Nancy E. Davidson, Kala Visvanathan, Akhilesh Pandey, Thomas W. Kensler

Preclinical Study

Prognostic value of acquired uniparental disomy (aUPD) in primary breast cancer

Musaffe Tuna, Marcel Smid, John W. M. Martens, John A. Foekens

Clinical Trial

Twenty-five year results of the national cancer institute randomized breast conservation trial

Nicole L. Simone, Tu Dan, Joanna Shih, Sharon L. Smith, Linda Sciuto, Elena Lita, Marc E. Lippman, Eli Glatstein, Sandra M. Swain, David N. Danforth, Kevin Camphausen

Clinical trial

Impact of a telephone-based physical activity intervention upon exercise behaviors and fitness in cancer survivors enrolled in a cooperative group setting

Jennifer A. Ligibel, Jeffrey Meyerhardt, John P. Pierce, Julie Najita, Laura Shockro, Nancy Campbell, Vicky A. Newman, Leslie Barbier, Eileen Hacker, Marie Wood, James Marshall, Electra Paskett, Charles Shapiro

Clinical trial

Phase 2 study of neoadjuvant treatment with NOV-002 in combination with doxorubicin and cyclophosphamide followed by docetaxel in patients with HER-2 negative clinical stage II–IIIc breast cancer

A. J. Montero, C. M. Diaz-Montero, Y. E. Deutsch, J. Hurley, L. G. Koniaris, T. Rumboldt, S. Yasir, M. Jorda, E. Garret-Mayer, E. Avisar, J. Slingerland, O. Silva, C. Welsh, K. Schuhwerk, P. Seo, M. D. Pegram, S. Glück

Clinical trial

TIMP-1 in combination with HER2 and TOP2A for prediction of benefit from adjuvant anthracyclines in high-risk breast cancer patients

Pernille Braemer Hertel, Dongsheng Tu, Bent Ejlertsen, Maj-Britt Jensen, Eva Balslev, Shan Jiang, Frances P. O’Malley, Kathleen I. Pritchard, Lois E. Shepherd, Annette Bartels, Nils Brünner, Torsten O. Nielsen

Clinical trial

Incremental increase in VEGFR1+ hematopoietic progenitor cells and VEGFR2+ endothelial progenitor cells predicts relapse and lack of tumor response in breast cancer patients

Sarika Jain, Maureen M. Ward, Jennifer O’Loughlin, Marissa Boeck, Naomi Wiener, Ellen Chuang, Tessa Cigler, Anne Moore, Diana Donovan, Christina Lam, Marta V. Cobham, Sarah Schneider, Paul Christos, Rebecca N. Baergen, Alexander Swistel, Maureen E. Lane, Vivek Mittal, Shahin Rafii, Linda T. Vahdat

Epidemiology

Folate intake and breast cancer mortality in a cohort of Swedish women

Holly R. Harris, Leif Bergkvist, Alicja Wolk

Epidemiology

Polymorphisms in cycloxygenase-2 gene and breast cancer prognosis: association between PTGS2 haplotypes and histopathological features

Juliana S. Festa-Vasconcellos, Diogo N. Piranda, Laura M. Amaral, Vanessa Indio-do-Brasil, Sérgio Koifman, Rosane Vianna-Jorge

Epidemiology

The association between mammographic density measures and aspirin or other NSAID use

Jennifer Stone, Lisa Willenberg, Carmel Apicella, Susan Treloar, John Hopper

Epidemiology

Epstein–Barr virus is seldom found in mammary epithelium of breast cancer tissue using in situ molecular methods

Kimberly Baltzell, Gertrude C. Buehring, Savitri Krishnamurthy, Henry Kuerer, Hua Min Shen, Jennette D. Sison

Epidemiology

Breast tenderness and breast cancer risk in the estrogen plus progestin and estrogen-alone women’s health initiative clinical trials

Carolyn J. Crandall, Aaron K. Aragaki, Jane A. Cauley, Anne McTiernan, JoAnn E. Manson, Garnet Anderson, Rowan T. Chlebowski

Epidemiology

Women’s features and inter-/intra-rater agreement on mammographic density assessment in full-field digital mammograms (DDM-SPAIN)

Beatriz Pérez-Gómez, Franciso Ruiz, Inmaculada Martínez, María Casals, Josefa Miranda, Carmen Sánchez-Contador, Carmen Vidal, Rafael Llobet, Marina Pollán, Dolores Salas

Epidemiology

Hormone therapy use and mammographic density in postmenopausal Norwegian women

Elisabeth Couto, Samera Azeem Qureshi, Solveig Hofvind, Marit Hilsen, Hildegunn Aase, Per Skaane, Lars Vatten, Giske Ursin

Epidemiology

Detection of a large rearrangement in PALB2 in Spanish breast cancer families with male breast cancer

Ana Blanco, Miguel de la Hoya, Judith Balmaña, Teresa Ramón y Cajal, Alex Teulé, María-Dolores Miramar, Eva Esteban, Mar Infante, Javier Benítez, Asunción Torres, María-Isabel Tejada, Joan Brunet, Begoña Graña, Milagros Balbín, Pedro Pérez-Segura, Ana Osorio, Eladio A. Velasco, Isabel Chirivella, María-Teresa Calvo, Lidia Feliubadaló, Adriana Lasa, Orland Díez, Angel Carracedo, Trinidad Caldés, Ana Vega

Epidemiology

Prognostic role of CA15.3 in 7942 patients with operable breast cancer

M. T. Sandri, M. Salvatici, E. Botteri, R. Passerini, L. Zorzino, N. Rotmensz, A. Luini, C. Mauro, V. Bagnardi, M. C. Cassatella, F. Bottari, C. Casadio, M. Colleoni

Brief Report

Somatic mutations in the BRCA1 gene in Chinese women with sporadic breast cancer

Min Zhang, Ye Xu, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Brief Report

Lack of association between common single nucleotide polymorphisms in the TERT-CLPTM1L locus and breast cancer in women of African ancestry

Yonglan Zheng, Temidayo O. Ogundiran, Clement Adebamowo, Katherine L. Nathanson, Susan M. Domchek, Timothy R. Rebbeck, Michael S. Simon, Esther M. John, Anselm Hennis, Barbara Nemesure, Suh-Yuh Wu, Maria Cristina Leske, Stefan Ambs, Qun Niu, Jing Zhang, Nancy J. Cox, Olufunmilayo I. Olopade, Dezheng Huo

Brief Report

Evaluating breast cancer risk projections for Hispanic women

Matthew P. Banegas, Mitchell H. Gail, Andrea LaCroix, Beti Thompson, Maria Elena Martinez, Jean Wactawski-Wende, Esther M. John, F. Allan Hubbell, Shagufta Yasmeen, Hormuzd A. Katki

Umsetzung der POMGAT-Leitlinie läuft

03.05.2024 DCK 2024 Kongressbericht

Seit November 2023 gibt es evidenzbasierte Empfehlungen zum perioperativen Management bei gastrointestinalen Tumoren (POMGAT) auf S3-Niveau. Vieles wird schon entsprechend der Empfehlungen durchgeführt. Wo es im Alltag noch hapert, zeigt eine Umfrage in einem Klinikverbund.

CUP-Syndrom: Künstliche Intelligenz kann Primärtumor finden

30.04.2024 Künstliche Intelligenz Nachrichten

Krebserkrankungen unbekannten Ursprungs (CUP) sind eine diagnostische Herausforderung. KI-Systeme können Pathologen dabei unterstützen, zytologische Bilder zu interpretieren, um den Primärtumor zu lokalisieren.

Sind Frauen die fähigeren Ärzte?

30.04.2024 Gendermedizin Nachrichten

Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders gilt das offenbar für weibliche Kranke, wie eine Studie zeigt.

Adjuvante Immuntherapie verlängert Leben bei RCC

25.04.2024 Nierenkarzinom Nachrichten

Nun gibt es auch Resultate zum Gesamtüberleben: Eine adjuvante Pembrolizumab-Therapie konnte in einer Phase-3-Studie das Leben von Menschen mit Nierenzellkarzinom deutlich verlängern. Die Sterberate war im Vergleich zu Placebo um 38% geringer.

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