Ausgabe 1/1997
Inhalt (16 Artikel)
Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial
Martin A. Graham, Suresh Senan, Hernani Robin Jr., Nils Eckhardt, Dennis Lendrem, Jeffery Hincks, Dennis Greenslade, Roy Rampling, Stanley B. Kaye, Reinhard von Roemeling, Paul Workman
Cellular uptake and antitumor activity of the new anthracycline analog DA-125 in human cancer cell lines
Kyoung-Hwa Lim, Hun-Sik Kim, Yong-Man Yang, Sang-Deuk Lee, Won-Bae Kim, Junnick Yang, J.-G. Park
Arterial occlusion in patients with peripheral vascular disease treated with platinum-based regimens for lung cancer
John Mathews, Rakesh Goel, William K. Evans, Farid Shamji, D. J. Stewart
Effect of glutathione depletion on the cytotoxicity of cisplatin and iproplatin in a human melanoma cell line
L. Pendyala, R. Perez, A. Weinstein, J. Zdanowicz, P. J. Creaven
Overexpression of thioredoxin does not confer resistance to cisplatin in transfected human ovarian and colon cancer cell lines
Manabu Yamada, Akihiro Tomida, Hiroyuki Yoshikawa, Yuji Taketani, T. Tsuruo
Pharmacokinetics of trofosfamide and its dechloroethylated metabolites
G. Hempel, Sebastian Krümpelmann, Antje May-Manke, Barbara Hohenlöchter, Gottfried Blaschke, Heribert Jürgens, Joachim Boos
Combination chemotherapy involving orally administered etoposide and JM-216 in murine tumor models
William C. Rose
Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity
Won G. An, Rodney C. Schnur, Len Neckers, M. V. Blagosklonny
Characterization of cellular accumulation and toxicity of illudin S in sensitive and nonsensitive tumor cells
M. J. Kelner, Trevor C. McMorris, Mark A. Montoya, Leita Estes, Mary Rutherford, Kyra M. Samson, Raymond Taetle
Quantification of 4-hydroxyifosfamide in plasma of ifosfamide-treated mice
R. F. Struck, D. M. McCain, S. W. Tendian, K. H. Tillery
Thiotepa and etoposide treatment of recurrent malignant gliomas: phase I study
Casilda Balmaceda, M. R. Fetell, Charles Hesdorffer
An investigation of the antitumour activity and biodistribution of polymeric micellar paclitaxel
Xichen Zhang, Helen M. Burt, Daniel Von Hoff, Daniel Dexter, Gina Mangold, Donna Degen, Ann Marie Oktaba, W. L. Hunter
Host distribution and response to antitumor alkylating agents of EMT-6 tumor cells from subcutaneous tumor implants
Sylvia A. Holden, Yasunori Emi, Yoshihiro Kakeji, David Northey, B. A. Teicher
Glutathione content but not gamma glutamyl cysteine synthetase mRNA expression predicts cisplatin resistance in head and neck cancer cell lines
Kenneth Newkirk, Joseph Heffern, Erik Sloman-Moll, Roy B. Sessions, Audrey A. Rasmussen, Paul A. Andrews, Kevin J. Cullen
Establishment of a cisplatin-resistant gastric carcinoma cell line OCUM-2M/DDP
Atsunori Nitta, Yong-Suk Chung, B. Nakata, Masakazu Yashiro, Naoyoshi Onoda, Kiyoshi Maeda, Tetsuji Sawada, Michio Sowa