Ausgabe Sonderheft 1/2010
5th European Workshop on Immune-Mediated Inflammatory Diseases
Inhalt (97 Artikel)
Immunosurveillance by gamma delta T cells - lessons from the cancer field
A C Hayday, E Binda, A Robert, M Serrano, F Dieli
A genomic approach to biomarker discovery in human autoimmune diseases
V Pascual
Skin-derived tumor specific T cells predict clinical outcome in dendritic cell vaccination studies in both stage III and IV melanoma patients
EHJG Aarntzen, W J Lesterhuis, M Van Rossum, G J Adema, C F Figdor, CJA Punt, IJM De Vries
HLA guided epitope discovery in Type 1 diabetes to generate novel therapeutics
M Peakman
Crohn’s disease is caused by a failure of the innate immune response with major abnormalities in macrophage biology
A W Segal
Human T helper cells in immunity and autoimmunity: Th17 and beyond
F Sallusto
Exploring new inflammatory pathways in the synovium
I B McInnes
Primary antibody deficiencies in the context of normal B-cell differentiation
M van der Burg
Early-onset inflammatory bowel disease caused by mutant IL10 receptor
E O Glocker, D Kotlarz, K Boztug, E M Gertz, A A Schäffer, F Noyan, M Perro, J Diestelhorst, A Allroth, D Murugan, N Hätscher, D Pfeifer, K W Sykora, M Sauer, H Kreipe, M Lacher, R Nustede, C Woellner, U Baumann, U Salzer, S Koletzko, N Shah, A W Segal, A Sauerbrey, S Buderus, S B Snapper, B Grimbacher, C Klein
Chemokines as inflammatory mediators of fibrosis in liver fibrosis
H E Wasmuth
Biomarkers inform clinical trials and pathogenesis in systemic sclerosis
R Lafyatis
Mechanisms of accelerated atherosclerosis associated with IMIDs
Z Mallat
Understanding the molecular bases of tissue inflammation
R A Flavell
Identification of novel genetic markers associated with the clinical phenotypes of systemic sclerosis through a genome wide association strategy
O Gorlova, J M Martin, B Rueda, BPC Koeleman, J Ying, M Teruel, L M Diaz-Gallo, J C Broen, M C Vonk, C P Simeon, B Z Alizadeh, MJH Coenen, A E Voskuyl, A J Schuerwegh, PLCM van Riel, M Vanthuyne, R van ‘t Slot, A Italiaander, R A Ophoff, N Hunzelmann, V Fonollosa, N Ortego-Centeno, M A González-Gay, F J García-Hernández, M F González-Escribano, P Airo, J van Laar, J Worthington, R Hesselstrand, V Smith, F De Keyser, F Houssiau, M M Chee, R Madhok, P Shiels, R Westhovens, A Kreuter, E de Baere, T Witte, L Padyukov, A Nordin, R Scorza, C Lunardi, B A Lie, A M Hoffmann-Vold, P García de la Peña, P Carreira, J Varga, M Hinchcliff, A T Lee, P Gourh, C I Amos, G Riemekasten, A Herrick, L Beretta, C Fonseca, C P Denton, P K Gregersen, S Agarwal, S Assassi, F K Tan, F C Arnett, TRDJ Radstake, M D Mayes, J Martin
Linking genotype to cell function in chronic inflammation: analysis of the IL-23/Th17 axis in spondylarthropathy
M Roumier, M Coffre, H Law, C Salliot, M Dougados, E Bianchi, L Rogge
Cytosolic phospholipase A2α gene silencing in monocytes alters development of Th1 responses and reduces autoimmune arthritis
G Courties, J Presumey, M Baron, V Escriou, P Van Lent, D Scherman, A Cantagrel, W Van den Berg, C Jorgensen, J-L Davignon, F Apparailly
RANKL expression in human T-lymphocytes requires cooperative signaling through the T-cell receptor and adhesion molecule CD2
B P Harvey, Z Kaymakcalan
Single-cell analysis techniques reveal a striking heterogeneity of human CD4+ T cell subsets
M Coffre, K Placek, S Maiella, E Bianchi, L Rogge
Sustained T cell Rap1 activation protects against Experimental Autoimmune Encephalomyelitis (EAE) via modulation of T cell responses
G Franco Salinas, S Krausz, W Dontje, P P Tak, D Baeten, K Reedquist
Skewed X-chromosomal inactivation impacts T regulatory cell function in systemic sclerosis
JCA Broen, ILM Wolvers-Tettero, L Geurts-van Bon, M C Vonk, MJH Coenen, R Lafyatis, TRDJ Radstake, A W Langerak
Fra-1 regulates inflammatory and degenerative arthritis
T Kireva, K Zwerina, W Baum, S Hayer, G Schett, J Zwerina
The neonatal Fc receptor is expressed by human lymphocytes
K van Bilsen, J Bastiaans, W A Dik, E F De Haas, S G Baarsma, R W Kuipers, P M van Hagen
Differential association of two PTPN22 coding variants with Crohn’s disease and ulcerative colitis
L M Diaz-Gallo, L Espino-Paisán, K Fransen, M Gómez-García, S van Sommeren, C Cardeña, L Rodrigo, J L Mendoza, C Taxonera, A Nieto, G Alcain, I Cueto, M A López-Nevot, N Bottini, M L Barclay, J B Crusius, A A van Bodegraven, C Wijmenga, C Y Ponsioen, R B Gearry, R L Roberts, R K Weersma, E Urcelay, T R Merriman, B Z Alizadeh, J Martin
Single-cell gene profiling analysis of human regulatory T cell subsets
S Maiella, S Dong, C Becavin, M Coffre, K Placek, E Bianchi, A Benecke, L Rogge
TLR signals modify the expression of scavenger receptors
C Zamora, E Cantó, J C Nieto, C Juarez, S Vidal
A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with Systemic Sclerosis in a large European cohort
L Bossini-Castillo, JCA Broen, C P Simeon, L Beretta, M C Vonk, N Ortego-Centeno, G Espinosa, P Carreira, M T Camps, N Navarrete, M F González-Escribano, E Vicente-Rabaneda, L Rodríguez, C Tolosa, J A Román-Ivorra, I Gómez-Gracia, F J García-Hernández, I Castellví, M Gallego, A Fernández-Nebro, M V Egurbide, V Follonosa, P García de la Peña, A Pros, M A González-Gay, R Hesselstrand, G Riemekasten, T Witte, MJH Coenen, B P Koeleman, F Houssiau, V Smith, F De Keyser, R Westhovens, E De Langhe, A E Voskuyl, A J Schuerwegh, M M Chee, R Madhok, P Shiels, C Fonseca, C Denton, K Claes, L Padykov, A Nordin, Ø Palm, B A Lie, P Airó, R Scorza, J M van Laar, N Hunzelmann, A Kreuter, A Herrick, J Worthington, TRDJ Radstake, J Martín, B Rueda
IMID-Biobank: Biobank of immune-mediated inflammatory diseases (IMIDs)
S Marsal, J Cañete, J Tornero, A Fernandez-Nebro, J M Hernanz, J Panes, A Julià, R Tortosa
Genetic polymorphisms of inflammatory molecules in Tunisian inflammatory bowel diseases
Y Gorgi, W Ben Aleya, D Khazen, I Sfar, H Aounallah-Skhiri, L Mouelhi, S Jendoubi-Ayed, M Makhlouf, T Ben Rhomdhane, S Matri, A Filali, H Aouadi, T Najjar, K Ayed, T Ben Abdallah
Cytokines and apoptosis genes polymorphisms influence the outcome of hepatitis C virus infection
L Ksiaa-Cheikh Rouhou, I Sfar, H Aounallah-Skhiri, H Aouadi, S Jendoubi-Ayed, T Ben Abdallah, K Ayed, Y Lakhoua-Gorgi
Lack of adalimumab's complement dependent cytotoxicity on human cells expressing complement regulatory proteins
K M Grebe, J Salfeld, Z Kaymakcalan
Efficacy of adalimumab in sarcoidosis
LSJ Kamphuis, W K Lam-Tse, W A Dik, J Bastiaans, P van Biezen, PLA van Daele, D J Kwekkeboom, RWAM Kuijpers, G S Baarsma, P M van Hagen, H Hooijkaas, JAM van Laar
Differences in virus prevalence and load in the hearts of patients with chronic dilated cardiomyopathy with and without immune-mediated inflammatory disease
R Dennert, P van Paassen, C Bruggeman, P Wolffs, J W Cohen Tervaert, S Heymans
Inflammatory T-lymphocyte proliferation in morbid obesity
K Van der Weerd, P M van Hagen, W A Dik, B S Schrijver, D H Schweitzer, A W Langerak, R M Kiewiet, M O Van Aken, JJM Van Dongen, A J Van der Lelij, FJT Staal
Elevated soluble Flt1 mediates an anti-angiogenic state in patients with ANCA-associated vasculitis
S Le Roux, R Pepper, A Dufay, M Néel, N Lamandé, M Rimbert, R Josien, M Hamidou, M Hourmant, H T Cook, B Charreau, E Larger, A Salama, F Fakhouri
Functional relevance of a non-synonymous substitution in the CD5 gene (V471A) targeted for positive selection in East Asian populations
T Bielig, E Carnero-Montoro, L Bonet, J Engelken, M Arias, E Bosch, F Lozano
Atopy in cutaneous and arthropatic psoriasis
E Hajdarbegovic, AAA Westgeest, H B Thio
Safety of treatment with biologics for psoriasis in daily practice: 5-year data
PPM Van Lümig, RJB Driessen, MAM Berends, J B Boezeman, PCM van de Kerkhof, EMGJ de Jong
CCL4L polymorphisms and serum levels are associated with psoriasis severity
E Pedrosa, L Carretero-Iglesia, A Boada, R Colobran, I Pujol-Autonell, R Pujol-Borrell, C Ferrándiz, M Juan, J M Carrascosa
Demonstration of novel innate immune cells in psoriasis
R Mak, C Hundhausen, E Botti, U Laggner, K Grys, I Tosi, F O Nestle
Expression of IL-1 family members upon stimulation with IL-17 differs in keratinocytes derived from psoriasis patients and healthy donors
P Muhr, J Zeitvogel, T Werfel, M Wittmann
Mutations in the Fas gene found in Spanish ALPS (autoimmune lymphoproliferative syndrome) patients
L Martínez-Martínez, C González-Santesteban, M V Rubiales, M Orta, I Badell, O de la Calle-Martin
Discovery and validation of immunological biomarkers using an advanced flow cytometry platform
F Villanova, P Di Meglio, M Inokuma, V C Maino, F O Nestle
Mast cells are major contributors to the pathophysiology of Graves’ Ophthalmopathy (GO)
L Van Steensel, D Paridaens, P M van Hagen, RWAM Kuijpers, W A Van den Bosch, H A Drexhage, H Hooijkaas, W A Dik
Perivascular adipocytes and signaling through toll-like receptors: role in the pathophysiology of atherosclerosis
C Benaiges, X Garcia-Moll, E Mateus, C Muñoz, E Cantó, E Pérez, R Leta, E Moga, S Vidal, C Juarez
Modulation of oxidative stress and TNFα secretion by peritoneal macrophages of arthritic rats fed with a flavonoid-enriched diet
S Ramos-Romero, F J Pérez-Cano, C Ramírez-Santana, C Castellote, A Franch, M Castell
Cocoa diet diminishes the anti-collagen humoral response in collagen-induced arthritis in rats
S Ramos-Romero, T Pérez-Berezo, F J Pérez-Cano, C Castellote, M Castell, A Franch
Toll-like receptor ligands regulate the migratory pattern of leukocytes
J C Nieto, E Cantó, M A Ortiz, C Juarez, S Vidal
T cell repertoire analysis and comparison between different compartments in two MS patients
M Salou, L Michel, A Garcia, A Elong-Ngono, S Wiertlewski, J P Soulillou, S Brouard, D A Laplaud
Mechanisms of action of Methylthioadenosine: pathways implicated in neuroprotection in models of Multiple Sclerosis and other neurological diseases
B Moreno, A Di Penta, M Kerschensteiner, C Matute, V Ceña, I Lopez, J Alberch, J Parent, J Serra, O Errea, P Villoslada
Natural Killer receptors distribution in Multiple Sclerosis
J E Martinez-Rodriguez, M López-Botet
Synovial fibroblast hyperplasia correlates with rheumatoid arthritis duration and activity and is partially reversed by anti-TNF therapy
E Izquierdo, J D Cañete, R Celis, M J Del Rey, A Usategui, S Marsal, R Sanmartí, G Criado, J L Pablos
Transcriptional response to hypoxia of normal and rheumatoid arthritis synovial fibroblasts
M J Del Rey, E Izquierdo, A Usategui, E Gonzalo, F J Blanco, F Acquadro, J L Pablos
Monitoring of anti-TNF biological treatments
A Ruiz del Agua, D Pascual-Salcedo, A Balsa, I Ramos, L Novalbos, S Ramiro, A Martínez, L Simón, D Nagore
Cytokine pattern in very early rheumatoid arthritis favours B cell activation and survival
R A Moura, R Cascão, I Perpétuo, H Canhão, E Vieira de Sousa, A F Mourão, A M Rodrigues, J Polido-Pereira, M Viana Queiroz, H S Rosário, M M Souto-Carneiro, L Graca, J E Fonseca
Identification of a cytokine network sustaining neutrophil and Th17 activation in untreated early rheumatoid arthritis
R Cascão, R A Moura, I Perpétuo, H Canhão, E Vieira de Sousa, A F Mourão, A M Rodrigues, J Polido-Pereira, M Viana Queiroz, H S Rosário, M M Souto-Carneiro, L Graca, J E Fonseca
Caspase-1 is active since the early phase of rheumatoid arthritis
R Cascão, J Polido-Pereira, H Canhão, A M Rodrigues, M Navalho, H Raquel, A F Mourão, C Resende, J E Fonseca, L F Moita
Spondyloarthropathy and rheumatoid arthritis: two different diseases, a similar cytokine network
R A Moura, R Cascão, I Perpétuo, H Canhão, E Vieira de Sousa, A F Mourão, A M Rodrigues, J Polido-Pereira, J A Pereira da Silva, H S Rosário, M M Souto-Carneiro, L Graca, J E Fonseca
Certolizumab pegol has a different profile from other anti-TNFs, including golimumab, in a variety of in vitro assays
G Fossati, A Nesbitt
Influence of variants of Fcg receptor IIA on the European league against rheumatism responses to anti-tumour necrosis factor alpha therapy in psoriatic arthritis
J Ramirez, J L Fernadez-Sueiro, R Lopez, C Montilla, B Suarez, C Moll, R Rodriguez, F Blanco, M Alsina, R Sanmarti, F Lozano, J Cañete
Identification of distinct polarized macrophage subsets in inflammatory arthritis
C Ambarus, S Krausz, J Hamann, M H Wenink, TRDJ Radstake, P P Tak, D Baeten
Fecal S100A12 levels measured by a new ELISA are increased in ulcerative colitis (UC) and Crohn’s disease (CD) and correlates with intestinal damage
P Garnero, C Préaudat, S Vermeire
Preferential expression of NF-κB-inducing kinase (NIK) in blood vessels of rheumatoid arthritis synovial tissue containing ectopic lymphoid neogenesis
A R Noort, KPM van Zoest, S W Tas, P P Tak
IL-17A producing mast cells as therapeutic target in spondyloarthritis
N Yeremenko, I Gofita, T Noordenbos, P P Tak, J Canete, D Baeten
TNF and IL-6 differentially regulate the production of DKK-1, a master regulator of bone remodelling, by fibroblast-like synoviocytes
N Yeremenko, R Bisoendial, J Zwerina, G Schett, P P Tak, D Baeten
Descriptive study of patients with uveitis attended during one-year period - diagnostic classification and treatment
M V Hernández, V Ruiz-Esquide, J A Gomez-Puerta, J Ramirez, G Espinosa, A Adan, J D Cañete, R Sanmarti
Interstitial lung disease in patients with scleroderma - Treatment with rituximab
A Muñoz, R Martínez, S Rodríguez, M L Velloso, J L Marenco
Variants of PBEF predispose to systemic sclerosis and pulmonary arterial hypertension development
JCA Broen, P Gourh, M C Vonk, L Beretta, F Niederer, B Rueda, L Geurts-van Bon, C Brouwer, R Hesselstrand, A Herrick, J Worthington, N Hunzelman, C Denton, C Fonseca, G Riemekasten, H Kiener, R Scorza, C P Simeon, V Fonollosa, P Carreira, N Ortego-Centeno, M A Gonzalez-Gay, P Airò, MJH Coenen, M Mayes, D Kyburz, F C Arnett, J Martin, TRDJ Radstake
Polymorphisms in the interleukin 4, interleukin 13 and corresponding receptor genes are not associated with Systemic Sclerosis and do not influence gene expression
JCA Broen, P Dieude, M C Vonk, L Beretta, B Rueda, A Herrick, J Worthington, N Hunzelmann, G Riemekasten, H Kiener, R Scorza, C P Simeon, V Fonollosa, P Carreira, N Ortego-Centeno, M A Gonzalez-Gay, P Airò, MJH Coenen, A Aliprantis, J Martin, Y Allanore, TRDJ Radstake
Systemic sclerosis: focus on lipid profile implications in pro-thrombotic disorder
C Ancuta, E Ancuta, C Belibou, R Chirieac
Increased expression of A-kinase anchoring proteins in T cells from systemic lupus erythematosus patients
M J Pérez-Lorenzo, M Galindo, A J García-González, G Criado
Role of TRAILR1 and TNFR1A polymorphisms in the susceptibility and pharmacogenetics of rheumatoid arthritis and ankylosing spondylitis patients treated with infliximab
M J Morales-Lara, P Conesa-Zamora, V Santaclara, D Torres-Moreno, F Pedrero, J Corral, M Perez-Guillermo, F J Rodríguez-Martínez, E Soriano-Navarro
Influence of a polymorphism IL1B gene in the response of rheumatoid arthritis and ankylosing spondylitis patients treated with infliximab
M J Morales-Lara, P Conesa-Zamora, V Santaclara, D Torres-Moreno, F Pedrero, J Moreno-Morales, V Cogolludo
Painful myositis in the anti-synthetase syndrome with anti-PL12 antibodies
P Mehta, L Patel, F Roncaroli, M C Pickering, A Brand
Toll-like receptor dependent autoantigens in animal models and humans in use to improve collagen induced arthritis
B Marklein, Z Konthur, T Häupl, M J Shlomchik SR., G Steiner, H Lehrach, G R Burmester, F Apparailly, K Skriner
Myeloid cell subsets dynamic during progression of mouse collagen-induced arthritis
J Presumey, C Jorgensen, G Courties, F Apparailly
Anticitrullinated peptide antibodies (ACPA) in the serum of heavy smokers without arthritis - a differential role of associated pulmonary disease?
V Ruiz-Esquide, M J Gómara, V Peinado, J A Gómez-Puerta, M V Hernández, J A Barberá, J D Cañete, I Haro, R Sanmartí
BIK is a novel pro-apoptotic target gene for miR-125b in human monocytes
I Duroux-Richard, J Presumey, Y M Pers, S Fabre, C H Lecellier, J Gruen, T Häupl, A Grützkau, G Burmester, C Jorgensen, F Apparailly
National survey of patients with psoriatic arthritis in Spain: disease activity, pharmacological therapy and impact on quality of life
J D Cañete, R Rodríguez, J Ramírez
Cytokine expression in synovial tissue of psoriatic arthritis and its relationship with lymphoid neogenesis, disease activity and erosive disease: a longitudinal study
R Celis, J Ramírez, R Sanmartí, J L Pablos, J D Cañete
Interleukin-1-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in human OA chondrocytes is associated with histone H3K4 methylation
N Chabane, N Zayed, J Martel-Pelletier, J P Pelletier, H Fahmi
Valproic acid suppresses interleukin-1β-induced microsomal prostaglandin E2 Synthase-1 expression in chondrocytes
N Zayed, N Chabane, J Martel-Pelletier, J P Pelletier, N Duval, H Fahmi
Prostaglandin D2 enhances interleukin -1beta-induced cyclooxygenase-2 expression in osteoarthritic cartilage
N Zayed, F E El Mansouri, N Chabane, J Martel-Pelletier, J P Pelletier, H Fahmi
Patients with non-relapsing ANCA-associated vasculitis have increased numbers of circulating IL-10 producing Th17 cells
B Wilde, M Thewissen, P van Paassen, M Hilhorst, J Damoiseaux, O Witzke, J W Cohen Tervaert
BioRePortAP, an electronic clinical record coupled with a database: an example of its use in a single centre
R Campanilho-Marques, J Polido Pereira, A M Rodrigues, F Ramos, M J Saavedra, M Costa, J A Pereira da Silva, H Canhão, J E Fonseca
Eight years of experience with biological treatment in juvenile idiopathic arthritis
A F Mourão, A Rodrigues, F Vinagre, E Sousa, J Polido-Pereira, C Macieira, F Ramos, J Costa, J Gomes Pedro, J Pereira da Silva, J E Fonseca, M J Santos, H Canhão
Predictors of chronicity and the discriminative value of the new ACR/EULAR rheumatoid arthritis classification criteria in an untreated polyarthritis cohort with less than 6 weeks of disease duration
A F Mourão, H Canhão, R A Moura, R Cascão, P Weinmann, A Rodrigues, J Pereira, C Resende, S Capela, J A Pereira da Silva, J E Fonseca
The effect of Rituximab treatment on T cells
C Diaz-Torné, M A Ortiz, C Zamora, H Corominas, E Perez-Ranz, A M Laiz, J Llobet, C Geli, C Juarez, C Diaz, S Vidal
Proteomic analysis of Systemic Sclerosis serum identifies the toll-like receptor agonists S100A8/A9 as a novel possible pathogenic marker
L van Bon, A Loof, H Wittkowski, W van Heerde, M Vonk, J Roth, W van den Berg, P van Lent, TRDJ Radstake
Upregulation of inflammatory genes and downregulation of sclerostin are key elements for fracture healing
J Caetano-Lopes, A Lopes, A Rodrigues, D Fernandes, I P Perpétuo, T Monjardino, R Lucas, J Monteiro, Y T Konttinen, H Canhão, J E Fonseca
Rituximab reduces anti-cardiolipin levels in patients with systemic lupus erythematosus
R Martínez-Pérez, A Muñoz-Jiménez, S Rodríguez-Montero, A Fernández-Nebro, L Carreño, J L Marenco
Rituximab reduces the hospitalization in patients with systemic lupus erythematosus
R Martínez-Pérez, A Fernández-Nebro, M López-Lasanta, M L Velloso-Feijoo, A Muñoz-Jiménez, J López Longo, J L Marenco
Rituximab is effective in the treatment of nephritis in lupus patients, refractory to conventional immunosuppressive therapy
R Martínez, A Muñoz, M L Velloso, S Rodríguez Montero, M A Belmonte-López, J L Marenco
Analysis of biologic therapy in rheumatoid arthritis in a southern Spanish hospital population
J Uceda-Montañés, R Hernández-Sánchez, S Rodríguez-Montero, M L Velloso-Feijoo, A Muñoz-Jimenez, R Martínez-Perez, J L Marenco
Mycophenolate mofetil use in refractory juvenile systemic lupus erythematosus
R Marques, C Ponte, J E Fonseca, J Pereira, A Rodrigues, C Macieira, R Stone, C Simão, M Almeida, H Canhão, F Ramos, J Á Pereira da Silva