The PMCTA technique has only approximately 10 years of history of utilization for forensic pathology purposes [
5]. An increasing number of forensic medicine institutes are using the PMCTA examination technique. Different methods of approach were presented, referring to targeted examination of selected regions of the deceased person [
6,
7], with the attempts of validation of methods in comparison to microscopic [
8] and conventional autopsy examinations [
9]. Apart from different causes of vascular damage in violent and natural death cases, there are other changes referring to blood vessel pathology taken into consideration, including diagnosis of pulmonary embolism [
10], coronary thrombosis, and different aspects of coronary artery disease [
11‐
13] including the possibility of myocardial changes visible after CA administration. Vascular changes at different locations [
14] and due to specific illnesses [
15] were reported. The use of PMCTA, at first aimed only at examination of bodies of deceased adults, has been introduced for other cases, even with problematic technical issues [
16]. There are also reports referring to evaluation and visualization in cases after medical interventions related to the heart and great vessels [
17,
18]. The publications are aimed not only at diagnostic efficiency but also present different methods of CA administration [
10,
19,
20] with the propositions of standardized protocols [
4,
21]. As we understand that there are no universal “remedies” for evaluation of all cases, the advances and limitations in the development of examination methods with the use of administration of CA to cadavers were discussed [
22,
23]. A valuable achievement is that the presentation of cases referring to post-mortem imaging results are reaching scientific journals not only dedicated to forensic pathologists/radiologists, but also clinical disciplines [
24], which may give the opportunity for better understanding of the value of post-mortem diagnosis for evaluation of clinical problems. Recent publications provide evidence that PMCTA may give forensic post-mortem examination additional strength [
4]. Based on the cases presented in the current paper we may even claim that the PMCTA in selected cases might be the sufficient way of examination while combined with conventional external examination and toxicological sampling (investigation); however, histopathological examination of specimens (at least internal organs) seems to be necessary in cases of alleged medical error: for example, it may be crucial for the estimation of timing of critical changes (e.g. ruptures and necrosis).