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2015 | OriginalPaper | Buchkapitel

4. Stabile pflanzliche Nahrungsmittelallergene I:Lipid-Transfer-Proteine

verfasst von : Prof. Dr. rer. nat. Arnd Petersen, PD Dr. Jörg Kleine-Tebbe, Dr. rer. nat. Stephan Scheurer

Erschienen in: Molekulare Allergiediagnostik

Verlag: Springer Berlin Heidelberg

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Zusammenfassung

Lipid-Transfer-Proteine (LTP) kommen im gesamten Pflanzenreich vor (Panallergene) und können IgE-Sensibilisierungen und allergische Reaktionen unterschiedlichen Schweregrades ggfs. bis zum anaphylaktischen Schock auslösen. Die Allergene haben ein Molekulargewicht von ca. 6–10 kDa und sind sowohl thermisch als auch proteolytisch sehr stabil. Neben den Nahrungsmitteln (Früchte und Gemüse) kommen LTPs auch in Pollen vor. Die Sensibilisierung scheint über die Aufnahme der Nahrungsmittel zu erfolgen; die klinische Relevanz der Kreuzreaktivitäten mit Pollen-LTP ist noch unklar. Allergische Reaktionen gegen LTPs treten vorwiegend im Mittelmeerraum auf und sind in Nord- und Mitteleuropa selten. Insbesondere IgE-Reaktivitäten gegen das LTP des Pfirsichs (Pru p 3) werden häufig nachgewiesen, weshalb dieses als Markerallergen eingesetzt wird. Für die Klinik ist die Verbesserung der Diagnostik (Komponenten-aufgelöste Diagnostik) vorrangig zur Karenz möglicher LTPs als Auslöser; eine Therapie ist noch nicht verfügbar.

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Titel: Stabile pflanzliche Nahrungsmittelallergene I:Lipid-Transfer-Proteine
verfasst von: Prof. Dr. rer. nat. Arnd Petersen
PD Dr. Jörg Kleine-Tebbe
Dr. rer. nat. Stephan Scheurer
Verlag: Springer Berlin Heidelberg
Buch: Molekulare Allergiediagnostik
Print ISBN: 978-3-662-45220-2

Electronic ISBN: 978-3-662-45221-9

Copyright-Jahr: 2015
DOI: https://doi.org/10.1007/978-3-662-45221-9_4

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4. Stabile pflanzliche Nahrungsmittelallergene I:Lipid-Transfer-Proteine

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Neu im Fachgebiet HNO

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

Update HNO