nach oben

Brain Structure and Function

Erschienen in:

01.10.2009 | Review

Structure–function relationships in the processing of regret in the orbitofrontal cortex

verfasst von: Tobias Sommer, Jan Peters, Jan Gläscher, Christian Büchel

Erschienen in: Brain Structure and Function | Ausgabe 6/2009

Einloggen, um Zugang zu erhalten

Abstract

The influence of counterfactual thinking and regret on choice behavior has been widely acknowledged in economic science (Bell in Oper Res 30:961–981, 1982; Kahneman and Tversky in Judgment under uncertainty: heuristics and biases. Cambridge University Press, Cambridge, pp 201–210, 1982; Loomes and Sugden in Econ J 92:805–824, 1982). Neuroimaging studies have only recently begun to explore the neural correlates of this psychological factor and orbitofrontal cortex (OFC) activity was observed in several of them depending of the exact characteristics of the employed paradigm. This selective OFC involvement and, moreover, a consistently found dissociation of medial and lateral OFC activity clusters allow inferences to the function of this structure in counterfactual thinking and regret. Vice versa, the differential contribution of OFC subregions to these processes also adds evidence to the current debate on the function of this cortical structure in decision-making that attracted increasing attention in recent years.

Anderson AK, Christoff K, Stappen I, Panitz D, Ghahremani DG, Glover G, Gabrieli JD, Sobel N (2003) Dissociated neural representations of intensity and valence in human olfaction. Nat Neurosci 6:196–202PubMedCrossRef

Arana FS, Parkinson JA, Hinton E, Holland AJ, Owen AM, Roberts AC (2003) Dissociable contributions of the human amygdala and orbitofrontal cortex to incentive motivation and goal selection. J Neurosci 23:9632–9638PubMed

Ayton P, Fischer I (2004) The hot hand fallacy and the gambler’s fallacy: two faces of subjective randomness? Mem Cogn 32:1369–1378

Baird AA, Fugelsang JA (2004) The emergence of consequential thought: evidence from neuroscience. Philos Trans R Soc Lond B Biol Sci 359:1797–1804PubMedCrossRef

Barbas H (2007a) Specialized elements of orbitofrontal cortex in primates. Ann N Y Acad Sci 1121:10–32PubMedCrossRef

Barbas H (2007b) Flow of information for emotions through temporal and orbitofrontal pathways. J Anat 211:237–249PubMedCrossRef

Baron J, Hershey JC (1988) Outcome bias in decision evaluation. J Personal Soc Psychol 54:569–579CrossRef

Barrett LF, Bar M (2009) See it with feeling: affective predictions during object perception. Philos Trans R Soc Lond B Biol Sci 364:1325–1334PubMedCrossRef

Baumeister RF, Bratslavsky E, Finkenauer C (2001) Bad is stronger than good. Rev Gen Psychol 5:323–370CrossRef

Beer JS, Knight RT, D’Esposito M (2006) Controlling the integration of emotion and cognition. Psychol Sci 17:448–453PubMedCrossRef

Bell DE (1982) Regret in decision making under uncertainty. Oper Res 30:961–981CrossRef

Boorman ED, Behrens TE, Woolrich MW, Rushworth MF (2009) How green is the grass on the other side? Frontopolar cortex and the evidence in favor of alternative courses of action. Neuron 62:733–743PubMedCrossRef

Breiter HC, Aharon I, Kahneman D, Dale A, Shizgal P (2001) Functional imaging of neural responses to expectancy and experience of monetary gains and losses. Neuron 30:619–639PubMedCrossRef

Brown JW, Braver TS (2007) Risk prediction and aversion by anterior cingulate cortex. Cogn Affect Behav Neurosci 7:266–277PubMedCrossRef

Burns BD, Corpus B (2004) Randomness and inductions from streaks: “gambler’s fallacy” versus “hot hand”. Psychon Bull Rev 11:179–184PubMed

Byrne RM (2002) Mental models and counterfactual thoughts about what might have been. Trends Cogn Sci 6:426–431PubMedCrossRef

Camerer C (2005) Three cheers—psychological, theoretical, empirical—for loss aversion. J Mark Res 42:129–133CrossRef

Camille N, Coricelli G, Sallet J, Pradat-Diehl P, Duhamel JR, Sirigu A (2004) The involvement of the orbitofrontal cortex in the experience of regret. Science 304:1167–1170PubMedCrossRef

Carmichael ST, Price JL (1994) Architectonic subdivision of the orbital and medial prefrontal cortex in the macaque monkey. J Comp Neurol 346:366–402PubMedCrossRef

Carmichael ST, Price JL (1995) Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys. J Comp Neurol 363:615–641PubMedCrossRef

Carmon Z, Ariely D (2000) Focusing on the forgone: why value can appear so different to buyers and sellers. J Consum Res 2:360–370CrossRef

Cavada C, Company T, Tejedor J, Cruz-Rizzolo RJ, Reinoso-Suarez F (2000) The anatomical connections of the macaque monkey orbitofrontal cortex. A review. Cereb Cortex 10:220–242PubMedCrossRef

Chandrasekhar PV, Capra CM, Moore S, Noussair C, Berns GS (2008) Neurobiological regret and rejoice functions for aversive outcomes. Neuroimage 39:1472–1484PubMedCrossRef

Chau AW, Phillips JG, Von Baggo KL (2000) Departures from sensible play in computer blackjack. J Gen Psychol 127:426–438PubMedCrossRef

Chiu PH, Lohrenz TM, Montague PR (2008) Smokers’ brains compute, but ignore, a fictive error signal in a sequential investment task. Nat Neurosci 11:514–520PubMedCrossRef

Chua HF, Gonzalez R, Taylor SF, Welsh RC, Liberzon I (2009) Decision-related loss: regret and disappointment. Neuroimage 47:2031–2040PubMedCrossRef

Cohen MX, Schoene-Bake JC, Elger CE, Weber B (2009) Connectivity-based segregation of the human striatum predicts personality characteristics. Nat Neurosci 12:32–34PubMedCrossRef

Coricelli G, Critchley HD, Joffily M, O’Doherty JP, Sirigu A, Dolan RJ (2005) Regret and its avoidance: a neuroimaging study of choice behavior. Nat Neurosci 8:1255–1262PubMedCrossRef

Coricelli G, Dolan RJ, Sirigu A (2007) Brain, emotion and decision making: the paradigmatic example of regret. Trends Cogn Sci 11:258–265PubMedCrossRef

Critchley HD (2005) Neural mechanisms of autonomic, affective, and cognitive integration. J Comp Neurol 493:154–166PubMedCrossRef

Critchley HD, Elliott R, Mathias CJ, Dolan RJ (2000) Neural activity relating to generation and representation of galvanic skin conductance responses: a functional magnetic resonance imaging study. J Neurosci 20:3033–3040PubMed

Critchley HD, Mathias CJ, Dolan RJ (2001) Neural activity in the human brain relating to uncertainty and arousal during anticipation. Neuron 29:537–545PubMedCrossRef

Croxson PL, Johansen-Berg H, Behrens TE, Robson MD, Pinsk MA, Gross CG, Richter W, Richter MC, Kastner S, Rushworth MF (2005) Quantitative investigation of connections of the prefrontal cortex in the human and macaque using probabilistic diffusion tractography. J Neurosci 25:8854–8866PubMedCrossRef

Damasio AR (1996) The somatic marker hypothesis and the possible functions of the prefrontal cortex. Philos Trans R Soc Lond B Biol Sci 351:1413–1420PubMedCrossRef

Damasio AR, Tranel D, Damasio H (1990) Individuals with sociopathic behavior caused by frontal damage fail to respond autonomically to social stimuli. Behav Brain Res 41:81–94PubMedCrossRef

De Martino B, Kumaran D, Seymour B, Dolan RJ (2006) Frames, biases, and rational decision-making in the human brain. Science 313:684–687PubMedCrossRef

De Martino B, Kumaran D, Holt B, Dolan RJ (2009) The neurobiology of reference-dependent value computation. J Neurosci 29:3833–3842PubMedCrossRef

Deichmann R, Gottfried JA, Hutton C, Turner R (2003) Optimized EPI for fMRI studies of the orbitofrontal cortex. Neuroimage 19:430–441PubMedCrossRef

Deppe M, Schwindt W, Kramer J, Kugel H, Plassmann H, Kenning P, Ringelstein EB (2005) Evidence for a neural correlate of a framing effect: bias-specific activity in the ventromedial prefrontal cortex during credibility judgments. Brain Res Bull 67:413–421PubMedCrossRef

Deppe M, Schwindt W, Pieper A, Kugel H, Plassmann H, Kenning P, Deppe K, Ringelstein EB (2007) Anterior cingulate reflects susceptibility to framing during attractiveness evaluation. Neuroreport 18:1119–1123PubMedCrossRef

Elliott R, Friston KJ, Dolan RJ (2000) Dissociable neural responses in human reward systems. J Neurosci 20:6159–6165PubMed

Elliott R, Newman JL, Longe OA, Deakin JF (2003) Differential response patterns in the striatum and orbitofrontal cortex to financial reward in humans: a parametric functional magnetic resonance imaging study. J Neurosci 23:303–307PubMed

Elliott R, Agnew Z, Deakin JF (2008) Medial orbitofrontal cortex codes relative rather than absolute value of financial rewards in humans. Eur J Neurosci 27:2213–2218PubMedCrossRef

Epstude K, Roese NJ (2008) The functional theory of counterfactual thinking. Personal Soc Psychol Rev 12:168–192CrossRef

Ert E, Erev I (2007) Replicated alternatives and the role of confusion, chasing, regret in decision from experience. J Behav Decis Mak 20:305–322CrossRef

Fellows LK (2006) Deciding how to decide: ventromedial frontal lobe damage affects information acquisition in multi-attribute decision making. Brain 129:944–952PubMedCrossRef

Finger EC, Mitchell DG, Jones M, Blair RJ (2008) Dissociable roles of medial orbitofrontal cortex in human operant extinction learning. Neuroimage 43:748–755PubMedCrossRef

Glascher J, Rose M, Buchel C (2007) Independent effects of emotion and working memory load on visual activation in the lateral occipital complex. J Neurosci 27:4366–4373PubMedCrossRef

Glascher J, Hampton AN, O’Doherty JP (2008) Determining a role for ventromedial prefrontal cortex in encoding action-based value signals during reward-related decision making. Cereb Cortex 19:483–495PubMedCrossRef

Gomez Beldarrain M, Garcia-Monco JC, Astigarraga E, Gonzalez A, Grafman J (2005) Only spontaneous counterfactual thinking is impaired in patients with prefrontal cortex lesions. Brain Res Cogn Brain Res 24:723–726PubMedCrossRef

Gonzalez C, Dana J, Koshino H, Just M (2005) The framing effect and risky decisions: examining cognitive functions with fMRI. J Econ Psychol 26:1–20CrossRef

Gottfried JA, Dolan RJ (2004) Human orbitofrontal cortex mediates extinction learning while accessing conditioned representations of value. Nat Neurosci 7:1144–1152PubMedCrossRef

Hampton AN, Bossaerts P, O’Doherty JP (2006) The role of the ventromedial prefrontal cortex in abstract state-based inference during decision making in humans. J Neurosci 26:8360–8367PubMedCrossRef

Hampton AN, Adolphs R, Tyszka MJ, O’Doherty JP (2007) Contributions of the amygdala to reward expectancy and choice signals in human prefrontal cortex. Neuron 55:545–555PubMedCrossRef

Hare TA, O’Doherty J, Camerer CF, Schultz W, Rangel A (2008) Dissociating the role of the orbitofrontal cortex and the striatum in the computation of goal values and prediction errors. J Neurosci 28:5623–5630PubMedCrossRef

Hart S, Mas-Collel A (2003) Regret-based continuous-time dynamics. Games Econ Behav 45:375–394CrossRef

Hayden BY, Pearson JM, Platt ML (2009) Fictive reward signals in the anterior cingulate cortex. Science 324:948–950PubMedCrossRef

Hof PR, Mufson EJ, Morrison JH (1995) Human orbitofrontal cortex: cytoarchitecture and quantitative immunohistochemical parcellation. J Comp Neurol 359:48–68PubMedCrossRef

Hosokawa T, Kato K, Inoue M, Mikami A (2007) Neurons in the macaque orbitofrontal cortex code relative preference of both rewarding and aversive outcomes. Neurosci Res 57:434–445PubMedCrossRef

Hunt LT (2008) Distinctive roles for the ventral striatum and ventral prefrontal cortex during decision-making. J Neurosci 28:8655–8657CrossRef

Hynes CA, Baird AA, Grafton ST (2006) Differential role of the orbital frontal lobe in emotional versus cognitive perspective-taking. Neuropsychologia 44:374–383PubMedCrossRef

Izquierdo A, Murray EA (2005) Opposing effects of amygdala and orbital prefrontal cortex lesions on the extinction of instrumental responding in macaque monkeys. Eur J Neurosci 22:2341–2346PubMedCrossRef

Izquierdo A, Suda RK, Murray EA (2004) Bilateral orbital prefrontal cortex lesions in rhesus monkeys disrupt choices guided by both reward value and reward contingency. J Neurosci 24:7540–7548PubMedCrossRef

Kable JW, Glimcher PW (2007) The neural correlates of subjective value during intertemporal choice. Nat Neurosci 10:1625–1633PubMedCrossRef

Kahneman D, Tversky A (1979) Prospect theory: an analysis of decision under risk. Econometrica 47:263–291CrossRef

Kahneman D, Tversky A (1982) The simulation heuristic. In: Kahneman D, Slovic P, Tversky A (eds) Judgment under uncertainty: heuristics and biases. Cambridge University Press, Cambridge, UK, pp 201–210

Kheramin S, Body S, Mobini S, Ho MY, Velazquez-Martinez DN, Bradshaw CM, Szabadi E, Deakin JF, Anderson IM (2002) Effects of quinolinic acid-induced lesions of the orbital prefrontal cortex on inter-temporal choice: a quantitative analysis. Psychopharmacology (Berl) 165:9–17CrossRef

Kim H, Shimojo S, O’Doherty JP (2006) Is avoiding an aversive outcome rewarding? Neural substrates of avoidance learning in the human brain. PLoS Biol 4:e233PubMedCrossRef

Knutson B, Bossaerts P (2007) Neural antecedents of financial decisions. J Neurosci 27:8174–8177PubMedCrossRef

Knutson B, Wimmer GE, Rick S, Hollon NG, Prelec D, Loewenstein G (2008) Neural antecedents of the endowment effect. Neuron 58:814–822PubMedCrossRef

Kringelbach ML, Rolls ET (2003) Neural correlates of rapid reversal learning in a simple model of human social interaction. Neuroimage 20:1371–1383PubMedCrossRef

Kringelbach ML, Rolls ET (2004) The functional neuroanatomy of the human orbitofrontal cortex: evidence from neuroimaging and neuropsychology. Prog Neurobiol 72:341–372PubMedCrossRef

Kuhnen CM, Knutson B (2005) The neural basis of financial risk taking. Neuron 47:763–770PubMedCrossRef

Larrick RP, Boyles TL (1996) Avoiding regret in decisions with feedback: a negotiation example. Organ Behav Hum Decis Process 63:87–97CrossRef

Lewis PA, Critchley HD, Rotshtein P, Dolan RJ (2007) Neural correlates of processing valence and arousal in affective words. Cereb Cortex 17:742–748PubMedCrossRef

Liu X, Powell DK, Wang H, Gold BT, Corbly CR, Joseph JE (2007) Functional dissociation in frontal and striatal areas for processing of positive and negative reward information. J Neurosci 27:4587–4597PubMedCrossRef

Loewenstein GF, Lerner JS (2003) The role of affect in decision-making. In: Davidson RJ, Scherer KR, Goldsmith HH (eds) Handbook of affective sciences. Oxford University Press, Oxford, pp 616–642

Loewenstein GF, Weber EU, Hsee CK, Welch N (2001) Risk as feelings. Psychol Bull 127:267–286PubMedCrossRef

Loewenstein G, Rick S, Cohen JD (2008) Neuroeconomics. Annu Rev Psychol 59:647–672PubMedCrossRef

Lohrenz T, McCabe K, Camerer CF, Montague PR (2007) Neural signature of fictive learning signals in a sequential investment task. Proc Natl Acad Sci USA 104:9493–9498PubMedCrossRef

Loomes G, Sugden R (1982) Regret theory: an alternative theory of rational choice under uncertainty. Econ J 92:805–824CrossRef

Marchiori D, Warglien M (2008) Predicting human interactive learning by regret-driven neural networks. Science 319:1111–1113PubMedCrossRef

McClure SM, Laibson DI, Loewenstein G, Cohen JD (2004) Separate neural systems value immediate and delayed monetary rewards. Science 306:503–507PubMedCrossRef

McClure SM, Ericson KM, Laibson DI, Loewenstein G, Cohen JD (2007) Time discounting for primary rewards. J Neurosci 27:5796–5804PubMedCrossRef

Mellers BA, Schwartz A, Ritov I (1999) Emotion-based choice. J Exp Psychol Gen 128:332–345CrossRef

Milad MR, Quinn BT, Pitman RK, Orr SP, Fischl B, Rauch SL (2005) Thickness of ventromedial prefrontal cortex in humans is correlated with extinction memory. Proc Natl Acad Sci USA 102:10706–10711PubMedCrossRef

Mobini S, Body S, Ho MY, Bradshaw CM, Szabadi E, Deakin JF, Anderson IM (2002) Effects of lesions of the orbitofrontal cortex on sensitivity to delayed and probabilistic reinforcement. Psychopharmacology (Berl) 160:290–298CrossRef

Montague PR, King-Casas B, Cohen JD (2006) Imaging valuation models in human choice. Annu Rev Neurosci 29:417–448PubMedCrossRef

Murray EA, Izquierdo A (2007) Orbitofrontal cortex and amygdala contributions to affect and action in primates. Ann N Y Acad Sci 1121:273–296PubMedCrossRef

Nagai Y, Critchley HD, Featherstone E, Trimble MR, Dolan RJ (2004) Activity in ventromedial prefrontal cortex covaries with sympathetic skin conductance level: a physiological account of a “default mode” of brain function. Neuroimage 22:243–251PubMedCrossRef

Northoff G, Richter A, Gessner M, Schlagenhauf F, Fell J, Baumgart F, Kaulisch T, Kotter R, Stephan KE, Leschinger A, Hagner T, Bargel B, Witzel T, Hinrichs H, Bogerts B, Scheich H, Heinze HJ (2000) Functional dissociation between medial and lateral prefrontal cortical spatiotemporal activation in negative and positive emotions: a combined fMRI/MEG study. Cereb Cortex 10:93–107PubMedCrossRef

O’Doherty JP (2007) Lights, camembert, action! The role of human orbitofrontal cortex in encoding stimuli, rewards, and choices. Ann N Y Acad Sci 1121:254–272PubMedCrossRef

O’Doherty J, Kringelbach ML, Rolls ET, Hornak J, Andrews C (2001) Abstract reward and punishment representations in the human orbitofrontal cortex. Nat Neurosci 4:95–102PubMedCrossRef

O’Doherty J, Critchley H, Deichmann R, Dolan RJ (2003a) Dissociating valence of outcome from behavioral control in human orbital and ventral prefrontal cortices. J Neurosci 23:7931–7939PubMed

O’Doherty J, Winston J, Critchley H, Perrett D, Burt DM, Dolan RJ (2003b) Beauty in a smile: the role of medial orbitofrontal cortex in facial attractiveness. Neuropsychologia 41:147–155PubMedCrossRef

Ongur D, Price JL (2000) The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans. Cereb Cortex 10:206–219PubMedCrossRef

Ongur D, Ferry AT, Price JL (2003) Architectonic subdivision of the human orbital and medial prefrontal cortex. J Comp Neurol 460:425–449PubMedCrossRef

Padoa-Schioppa C, Assad JA (2006) Neurons in the orbitofrontal cortex encode economic value. Nature 441:223–226PubMedCrossRef

Padoa-Schioppa C, Assad JA (2008) The representation of economic value in the orbitofrontal cortex is invariant for changes of menu. Nat Neurosci 11:95–102PubMedCrossRef

Patterson JC 2nd, Ungerleider LG, Bandettini PA (2002) Task-independent functional brain activity correlation with skin conductance changes: an fMRI study. Neuroimage 17:1797–1806PubMedCrossRef

Pickens CL, Saddoris MP, Setlow B, Gallagher M, Holland PC, Schoenbaum G (2003) Different roles for orbitofrontal cortex and basolateral amygdala in a reinforcer devaluation task. J Neurosci 23:11078–11084PubMed

Rempel-Clower NL (2007) Role of orbitofrontal cortex connections in emotion. Ann N Y Acad Sci 1121:72–86PubMedCrossRef

Roesch MR, Olson CR (2005) Neuronal activity in primate orbitofrontal cortex reflects the value of time. J Neurophysiol 94:2457–2471PubMedCrossRef

Roesch MR, Taylor AR, Schoenbaum G (2006) Encoding of time-discounted rewards in orbitofrontal cortex is independent of value representation. Neuron 51:509–520PubMedCrossRef

Roese N (1999) Counterfactual thinking and decision making. Psychon Bull Rev 6:570–578PubMed

Roese NJ, Park S, Smallman R, Gibson C (2008) Schizophrenia involves impairment in the activation of intentions by counterfactual thinking. Schizophr Res 103:343–344PubMedCrossRef

Rolls ET (2005) Emotion explained. Oxford University Press, OxfordCrossRef

Rolls ET, Kringelbach ML, de Araujo IE (2003) Different representations of pleasant and unpleasant odours in the human brain. Eur J Neurosci 18:695–703PubMedCrossRef

Rolls ET, Grabenhorst F, Parris BA (2008) Warm pleasant feelings in the brain. Neuroimage 41:1504–1513PubMedCrossRef

Royet JP, Zald D, Versace R, Costes N, Lavenne F, Koenig O, Gervais R (2000) Emotional responses to pleasant and unpleasant olfactory, visual, and auditory stimuli: a positron emission tomography study. J Neurosci 20:7752–7759PubMed

Rozin P, Royman EB (2001) Negativity bias, negativity dominance and contagion. Personal Soc Psychol Rev 4:296–320CrossRef

Rudebeck PH, Walton ME, Smyth AN, Bannerman DM, Rushworth MF (2006) Separate neural pathways process different decision costs. Nat Neurosci 9:1161–1168PubMedCrossRef

Rudebeck PH, Bannerman DM, Rushworth MF (2008) The contribution of distinct subregions of the ventromedial frontal cortex to emotion, social behavior, and decision making. Cogn Affect Behav Neurosci 8:485–497PubMedCrossRef

Sailer U, Robinson S, Fischmeister FP, Moser E, Kryspin-Exner I, Bauer H (2007) Imaging the changing role of feedback during learning in decision-making. Neuroimage 37:1474–1486PubMedCrossRef

Schoenbaum G, Gottfried JA, Murray EA (eds) (2007) Linking affect to action: critical contributions of the orbitofrontal cortex. Wiley–Blackwell, New York

Schwartz B, Ward A, Monterosso J, Lyubomirsky S, White K, Lehman DR (2002) Maximizing versus satisficing: happiness is a matter of choice. J Pers Soc Psychol 83:1178–1197PubMedCrossRef

Shiv B, Loewenstein G, Bechara A, Damasio H, Damasio AR (2005) Investment behavior and the negative side of emotion. Psychol Sci 16:435–439PubMed

Small DM, Zatorre RJ, Dagher A, Evans AC, Jones-Gotman M (2001) Changes in brain activity related to eating chocolate: from pleasure to aversion. Brain 124:1720–1733PubMedCrossRef

Smeets PA, de Graaf C, Stafleu A, van Osch MJ, Nievelstein RA, van der Grond J (2006) Effect of satiety on brain activation during chocolate tasting in men and women. Am J Clin Nutr 83:1297–1305PubMed

Sundali J, Croson R (2006) Biases in casino betting: the hot hand and the gambler’s fallacy. Judgm Decis Mak 1:1–12

Sutton RS, Barto AG (1998) Reinforcement learning: an introduction (Adaptive computation and machine learning). MIT Press, Cambridge, MA

Tom SM, Fox CR, Trepel C, Poldrack RA (2007) The neural basis of loss aversion in decision-making under risk. Science 315:515–518PubMedCrossRef

Tremblay L, Schultz W (1999) Relative reward preference in primate orbitofrontal cortex. Nature 398:704–708PubMedCrossRef

Tversky A, Kahneman D (1974) Judgment under uncertainty: heuristics and biases. Science 185:1124–1131PubMedCrossRef

Tversky A, Kahneman D (1991) Loss aversion in riskless choice. Q J Econ 106:1039–1061CrossRef

Ursu S, Carter CS (2005) Outcome representations, counterfactual comparisons and the human orbitofrontal cortex: implications for neuroimaging studies of decision-making. Brain Res Cogn Brain Res 23:51–60PubMedCrossRef

Valentin VV, Dickinson A, O’Doherty JP (2007) Determining the neural substrates of goal-directed learning in the human brain. J Neurosci 27:4019–4026PubMedCrossRef

von Neumann J, Morgenstern O (1944) Theory of games and economic behavior. Princeton University Press, Princeton

Wallis JD (2007) Orbitofrontal cortex and its contribution to decision-making. Annu Rev Neurosci 30:31–56PubMedCrossRef

Weber B, Aholt A, Neuhaus C, Trautner P, Elger CE, Teichert T (2007) Neural evidence for reference-dependence in real-market-transactions. Neuroimage 35:441–447PubMedCrossRef

Weiskopf N, Hutton C, Josephs O, Turner R, Deichmann R (2007) Optimized EPI for fMRI studies of the orbitofrontal cortex: compensation of susceptibility-induced gradients in the readout direction. Magma 20:39–49PubMedCrossRef

Windmann S, Kirsch P, Mier D, Stark R, Walter B, Gunturkun O, Vaitl D (2006) On framing effects in decision making: linking lateral versus medial orbitofrontal cortex activation to choice outcome processing. J Cogn Neurosci 18:1198–1211PubMedCrossRef

Yechiam E, Busemeyer JR (2006) The effect of foregone payoffs on underweighting small probability events. J Behav Dec Mak 19:1–16CrossRef

Zeelenberg M, Pieters R (2007) A theory of regret regulation 1.0. J Consum Psychol 17:3–18CrossRef

Titel: Structure–function relationships in the processing of regret in the orbitofrontal cortex
verfasst von: Tobias Sommer
Jan Peters
Jan Gläscher
Christian Büchel
Publikationsdatum: 01.10.2009
Verlag: Springer-Verlag
Erschienen in: Brain Structure and Function / Ausgabe 6/2009
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-009-0222-8

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Schützt Olivenöl vor dem Tod durch Demenz?

10.05.2024 Morbus Alzheimer Nachrichten

Konsumieren Menschen täglich 7 Gramm Olivenöl, ist ihr Risiko, an einer Demenz zu sterben, um mehr als ein Viertel reduziert – und dies weitgehend unabhängig von ihrer sonstigen Ernährung. Dafür sprechen Auswertungen zweier großer US-Studien.

Bluttest erkennt Parkinson schon zehn Jahre vor der Diagnose

10.05.2024 Parkinson-Krankheit Nachrichten

Ein Bluttest kann abnorm aggregiertes Alpha-Synuclein bei einigen Menschen schon zehn Jahre vor Beginn der motorischen Parkinsonsymptome nachweisen. Mit einem solchen Test lassen sich möglicherweise Prodromalstadien erfassen und die Betroffenen früher behandeln.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Wartezeit nicht kürzer, aber Arbeit flexibler

Psychotherapie Medizin aktuell

Fünf Jahren nach der Neugestaltung der Psychotherapie-Richtlinie wurden jetzt die Effekte der vorgenommenen Änderungen ausgewertet. Das Hauptziel der Novellierung war eine kürzere Wartezeit auf Therapieplätze. Dieses Ziel wurde nicht erreicht, es gab jedoch positive Auswirkungen auf andere Bereiche.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2009

Paracingulate asymmetry in anterior and midcingulate cortex: sex differences and the effect of measurement technique

Structural MRI studies of language function in the undamaged brain

Brain volumes and Val66Met polymorphism of the BDNF gene: local or global effects?

Measurement of spontaneous signal fluctuations in fMRI: adult age differences in intrinsic functional connectivity

Greater than the sum of its parts: a review of studies combining structural connectivity and resting-state functional connectivity