Background
Methods
Materials and methods
All (n = 259) | CAD (n = 155) | Control (n = 104) | p (t-test) | |
---|---|---|---|---|
Age/ys. mean. ± SD | 53 ± 12 | 58 ± 11 | 47 ± 11 | < 0.001 |
BMI/kgm−2. mean ± SD | 28.0 ± 4,3 | 28.5 ± 4,0 | 27.2 ± 4,5 | 0.017 |
RR (S)/mmHg. mean ± SD | 124 ± 15 | 121 ± 15 | 127 ± 16 | 0.005 |
RR (D)/mmHg. mean ± SD | 78 ± 10 | 78 ± 10 | 78 ± 9 | 0.887 |
p (χ2 test) | ||||
---|---|---|---|---|
Gender/female N (%) | 64 (24.7) | 28 (18,1) | 36 (34,6) | 0.002 |
Arterial hypertension N (%) | 157 (60.6) | 117 (75.5) | 40 (38.5) | < 0.001 |
Hyperlipoproteinemia N (%) | 200 (77.2) | 122 (78.7) | 78 (75.0) | 0.485 |
Diabetes Mellitus N (%) | 38 (14.7) | 29 (18.7) | 9 (8.7) | 0.025 |
COPD N (%) | 5 (1.93) | 5 (3.2) | 0 (0) | 0.085* |
Smoking N (%) | 108 (41.7) | 86 (55.5) | 22 (21.2) | < 0.001 |
Positive family history N (%) | 154 (59.5) | 93 (60.0) | 61 (58.7) | 0.829 |
Exclusion criteria
DNA extraction and genetic analysis
Vitamin D serum level measurement
Statistics
Results
CAD | Control | P (χ2 test) | |||
---|---|---|---|---|---|
N | % | N | % | ||
VDR (rs2228570) | |||||
A/A | 21 | 13.5 | 18 | 17.3 | 0.67 |
A/G | 84 | 54.2 | 52 | 50.0 | |
G/G | 50 | 32.3 | 34 | 32.7 | |
Total | 155 | 100.0 | 104 | 100.0 | |
VDR (1544410) | |||||
C/C | 72 | 46.5 | 39 | 37.5 | 0.006 |
C/T | 60 | 38.7 | 59 | 56.7 | |
T/T | 23 | 14.8 | 6 | 5.8 | |
Total | 155 | 100.0 | 104 | 100.0 | |
VDR (rs731236) | |||||
A/A | 76 | 49.0 | 45 | 43.3 | 0.01 |
A/G | 57 | 36.8 | 54 | 51.9 | |
G/G | 22 | 14.2 | 5 | 4.8 | |
Total | 155 | 100.0 | 104 | 100.0 |
VDR (1544410) model | CAD | Control | p | OR | − 95% CL | + 95% CL | |
---|---|---|---|---|---|---|---|
Codominant Model 1 C/C vs T/C | C/C | 72 | 39 | 0.027 | 1.82 | 1.07 | 3.08 |
T/C | 60 | 59 | |||||
Codominant Model 2 C/C vs T/T | C/C | 72 | 39 | 0.138 | 0.48 | 0.18 | 1.28 |
T/T | 23 | 6 | |||||
Dominant Model C/C vs T/C + T/T | C/C | 72 | 39 | 0.154 | 1.45 | 0.87 | 2.40 |
T/C + T/T | 83 | 65 | |||||
Recessive Model C/C + T/C vs T/T | C/C + T/C | 132 | 98 | 0.023 | 0.35 | 0.14 | 0.90 |
T/T | 23 | 6 | |||||
Overdominant MoDEL C/C + T/T vs T/C | C/C + T/T | 95 | 45 | 0.004 | 2.08 | 1.25 | 3.44 |
T/C | 60 | 59 | |||||
Additive Model C/C vs 2 T/T + T/C | C/C | 72 | 39 | 0.397 | 1.24 | 0.76 | 2.02 |
2 T/T + T/C | 106 | 71 |
VDR (rs731236) Model | CAD | Control | p | OR | − 95% CL | + 95% CL | |
---|---|---|---|---|---|---|---|
Codominant Model 1 A/A vs A/G | A/A | 76 | 45 | 0.078 | 1.6 | 0.95 | 2.70 |
A/G | 57 | 54 | |||||
Codominant Model 2 A/A vs G/G | A/A | 76 | 45 | 0.064 | 0.38 | 0.14 | 1.08 |
G/G | 22 | 5 | |||||
Dominant Model A/A vs A/G + G/G | A/A | 76 | 45 | 0.362 | 1.26 | 0.77 | 2.08 |
A/G + G/G | 79 | 59 | |||||
Recessive Model A/A + A/G vs G/G | A/A + A/G | 133 | 99 | 0.016 | 0.31 | 0.11 | 0.83 |
G/G | 22 | 5 | |||||
Overdominant ModEL A/A + G/G vs A/G | A/A + G/G | 98 | 50 | 0.016 | 1.86 | 1.12 | 3.08 |
A/G | 57 | 54 | |||||
Additive Model A/A vs 2G/G + A/G | A/A | 76 | 45 | 0.783 | 1.07 | 0.66 | 1.74 |
2G/G + A/G | 101 | 64 |
N | 25 hydroxyvit D2 /nmol/L | 25 hydroxyvit D3 /nmol/L | Total vit D /nmol/L | |
---|---|---|---|---|
VDR (rs2228570) | ||||
A/A | 31 | 3.08 ± 3.90 | 57.71 ± 24.52 | 60.79 ± 24.65 |
A/G | 93 | 2.12 ± 3.33 | 59.38 ± 31.65 | 61.50 ± 31.39 |
G/G | 64 | 2.61 ± 3.63 | 52.06 ± 22.46 | 54.67 ± 22.77 |
p (ANOVA) | 188 | 0.385 | 0.261 | 0.294 |
p (factorial ANOVA, by gender) | 0.859 | 0.580 | 0.619 | |
VDR (1544410) | ||||
C/C | 74 | 2.78 ± 3.64 | 55.91 ± 25.22 | 58.69 ± 25.21 |
C/T | 90 | 2.26 ± 3.48 | 55.67 ± 28.77 | 57.93 ± 28.46 |
T/T | 24 | 2.11 ± 3.48 | 62.36 ± 31.64 | 64.46 ± 32.39 |
p (ANOVA) | 188 | 0.573 | 0.557 | 0.586 |
p (factorial ANOVA, by gender) | 0.743 | 0.782 | 0.795 | |
VDR (rs731236) | ||||
A/A | 82 | 2.89 ± 3.70 | 55.79 ± 25.38 | 58.69 ± 25.32 |
A/G | 83 | 2.18 ± 3.44 | 55.66 ± 28.80 | 57.84 ± 28.48 |
G/G | 23 | 1.79 ± 3.19 | 62.99 ± 32.20 | 64.78 ± 33.08 |
p (ANOVA) | 188 | 0.276 | 0.503 | 0.563 |
p (factorial ANOVA, by gender) | 0.847 | 0.862 | 0.878 |
CAD (smoking) | Control (smoking) | p (χ2 test) | |||
---|---|---|---|---|---|
N | % | N | % | ||
VDR (rs2228570) | |||||
A/A | 10 | 11.6 | 3 | 13.6 | 0.84 |
A/G | 47 | 54.7 | 13 | 59.1 | |
G/G | 29 | 33.7 | 6 | 27.3 | |
Total | 86 | 100.0 | 22 | 100.0 | |
VDR (1,544,410) | |||||
C/C | 41 | 47.7 | 9 | 40.9 | 0.104 |
C/T | 34 | 39.5 | 13 | 59.1 | |
T/T | 11 | 12.8 | 0 | 0.0 | |
Total | 86 | 100.0 | 22 | 100.0 | |
VDR (rs731236) | |||||
A/A | 44 | 51.2 | 10 | 45.5 | 0.109 |
A/G | 31 | 36.0 | 12 | 54.5 | |
G/G | 11 | 12.8 | 0 | 0.0 | |
Total | 86 | 100.0 | 22 | 100.0 |