Erschienen in:
01.09.2004 | Oral presentation
Subchondral bone architecture and quality in osteoarthritis
verfasst von:
RM Aspden
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 3/2004
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Excerpt
Osteoarthritis (OA) is traditionally seen as a disease of articular cartilage. However, changes in the bone that have long formed part of the radiological diagnosis – subchondral sclerosis, cysts and osteophytosis – are increasingly recognised as being an integral part of the disease. It is curious that cysts, regions of bone loss, are found in sites that are loaded, whereas osteophytes grow at the joint margins in sites that might be expected to be relatively lightly loaded. This is contrary to normal expectations of mechanical regulation of bone formation and resorption. Evidence from animal models of idiopathic OA suggests that bone changes may precede cartilage deterioration, which would indicate that they are part of the primary disease process. Patients with OA changes evident on hip radiographs were found to have a higher than average bone mineral density not only in the hip, but also in the distal radius, vertebrae and calcaneus. …
