Skip to main content
Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery 2/2023

21.01.2023 | Original Article

Submandibular Gland in Neck Dissection: Necessary Fatality or Unfortunate Prey?

verfasst von: Tashnin Rahman, Kirti Khandelwal, Srinivas Bannoth, Ashok Kumar Das, Rajjyoti Das, Kishore Das, Anupam Das, Kaberi Kakati

Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery | Ausgabe 2/2023

Einloggen, um Zugang zu erhalten

Abstract

Excision of submandibular gland is currently victim in all neck dissections. In this study we intend to estimate the prevalence of submandibular gland involvement in squamous cell oral carcinomas and identify the factors associated with it. This is a single institutional, retrospective observational study conducted from 22 to 2018 to 28 February 2020. 317 patients were included for analysis as per study criteria. The prevalence of involvement of submandibular gland was 3.8%. Increased risk of submandibular gland involvement was associated with involvement of level-Ib nodes (Odds ratio: 13.6, 2.9–63.3, 95% CI and p = < 0.001) and presence of extra-nodal extension (Odds ratio: 67, 8.4–532, 95% CI and p = < 0.001) and perineurial invasion (Odds ratio: 5, 1.6–16.8 and p = 0.003). In oral cancers, especially early stage carcinoma of buccal mucosa, submandibular gland preservation may be feasible in absence of extra-nodal extension and level-Ib involvement.
Literatur
1.
Zurück zum Zitat Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2020) Global Cancer Statistics 2020: GLOBOCON Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians. ;71:209 – 49 Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2020) Global Cancer Statistics 2020: GLOBOCON Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians. ;71:209 – 49
2.
Zurück zum Zitat Shah JP (2009) GilZ. Current concepts in management of oral cancer surgery. Oral Oncol 45:394–401CrossRefPubMed Shah JP (2009) GilZ. Current concepts in management of oral cancer surgery. Oral Oncol 45:394–401CrossRefPubMed
3.
Zurück zum Zitat D’Cruz AK, Vaish R, Kapre N et al (2015) Head and neck disease management group. Elective versus therapeutic neck dissection in node-negative oral cancer. N Engl J Med 373:521–529CrossRefPubMed D’Cruz AK, Vaish R, Kapre N et al (2015) Head and neck disease management group. Elective versus therapeutic neck dissection in node-negative oral cancer. N Engl J Med 373:521–529CrossRefPubMed
4.
Zurück zum Zitat Dhiwakar M, Ronen O, Malone J, Rao K, Bell S, Phillips R et al (2011) Feasibility of submandibular gland preservation in neck dissection: a prospective anatomic-pathologic study. Head Neck 33:603–609CrossRefPubMed Dhiwakar M, Ronen O, Malone J, Rao K, Bell S, Phillips R et al (2011) Feasibility of submandibular gland preservation in neck dissection: a prospective anatomic-pathologic study. Head Neck 33:603–609CrossRefPubMed
5.
Zurück zum Zitat Jaguar JC, Lima EN, Kowalski LP, Pellizon AC, Al C, Alves FA (2010) Impact of submandibular gland excision on salivary gland function in head and neck cancer patients. Oral Oncol 46:349–354CrossRefPubMed Jaguar JC, Lima EN, Kowalski LP, Pellizon AC, Al C, Alves FA (2010) Impact of submandibular gland excision on salivary gland function in head and neck cancer patients. Oral Oncol 46:349–354CrossRefPubMed
6.
Zurück zum Zitat Altuntas OM, Özer F, Kuscu O, Suslu N (2021) ;83:341 – 46 Altuntas OM, Özer F, Kuscu O, Suslu N (2021) ;83:341 – 46
7.
Zurück zum Zitat Mathur P, Satishkumar K, Chaturvedi M, Das P, Sudarshan KL, Santappan S et al (2020) Cancer Statistics, 2020: report from National Cancer Registry Programme, India. JCO Global Oncol 6:1063–1075CrossRef Mathur P, Satishkumar K, Chaturvedi M, Das P, Sudarshan KL, Santappan S et al (2020) Cancer Statistics, 2020: report from National Cancer Registry Programme, India. JCO Global Oncol 6:1063–1075CrossRef
8.
Zurück zum Zitat Sharma P, Deb T, Ray JG, Kumar A, Gupta G, Das A, Srivatsava S (2018) Oral squamous cell carcinoma profile in North-eastern regions of India from habits to histopathology: a hospital-based study. Natl J Maxillofac Surg 9:56–60CrossRefPubMedPubMedCentral Sharma P, Deb T, Ray JG, Kumar A, Gupta G, Das A, Srivatsava S (2018) Oral squamous cell carcinoma profile in North-eastern regions of India from habits to histopathology: a hospital-based study. Natl J Maxillofac Surg 9:56–60CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Bernier J, Cooper JS, Pajak TF, Bourhis J, Arlene Forastiere EM, Ozsahin et al (2005) Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of EORTC (#22931) and RTOG (#9501). Head Neck 27:843–850CrossRefPubMed Bernier J, Cooper JS, Pajak TF, Bourhis J, Arlene Forastiere EM, Ozsahin et al (2005) Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of EORTC (#22931) and RTOG (#9501). Head Neck 27:843–850CrossRefPubMed
11.
Zurück zum Zitat Yang S, Wang X, Su JZ, Yu GY (2019) Rate of Submandibular Gland involvement in oral squamous cell carcinoma. J Oral Maxillofac Surg 77:1000–1008CrossRefPubMed Yang S, Wang X, Su JZ, Yu GY (2019) Rate of Submandibular Gland involvement in oral squamous cell carcinoma. J Oral Maxillofac Surg 77:1000–1008CrossRefPubMed
12.
Zurück zum Zitat Rouviere H, Tobies MJ (1939) translator. Anatomy of Human Lymphatic System. Ann Arbor, MI:Edwards Brothers Rouviere H, Tobies MJ (1939) translator. Anatomy of Human Lymphatic System. Ann Arbor, MI:Edwards Brothers
13.
Zurück zum Zitat DiNardo LJ (1998) Lymphatics of submandibular space: an anatomic, clinical and pathologic study with applications to floor of mouth carcinoma. Laryngoscope 108:206–214CrossRefPubMed DiNardo LJ (1998) Lymphatics of submandibular space: an anatomic, clinical and pathologic study with applications to floor of mouth carcinoma. Laryngoscope 108:206–214CrossRefPubMed
14.
Zurück zum Zitat Yang S, Su JZ, Gao Y, Yu GY (2020) Clinicopathological study of involvement of the submandibular gland in oral squamous cell carcinoma. Br J Oral Maxillofac Surg 58:203–207CrossRefPubMed Yang S, Su JZ, Gao Y, Yu GY (2020) Clinicopathological study of involvement of the submandibular gland in oral squamous cell carcinoma. Br J Oral Maxillofac Surg 58:203–207CrossRefPubMed
15.
Zurück zum Zitat Springborg LK, Møller MN (2013) Submandibular gland excision: long-term clinical outcome in 139 patients operated in a single institution. Eur Arch Otorhinolaryngol 270:1441–1446CrossRefPubMed Springborg LK, Møller MN (2013) Submandibular gland excision: long-term clinical outcome in 139 patients operated in a single institution. Eur Arch Otorhinolaryngol 270:1441–1446CrossRefPubMed
16.
Zurück zum Zitat Berini-Aytes L, Gay-Escoda C (1992) Morbidity associated with removal of submandibular gland. J Craniomaxillofac Surg 20:216–219CrossRefPubMed Berini-Aytes L, Gay-Escoda C (1992) Morbidity associated with removal of submandibular gland. J Craniomaxillofac Surg 20:216–219CrossRefPubMed
17.
Zurück zum Zitat Dundar Y, Mandle Q, Raza SN, Lin HS, Cramer J, Hotaling JM (2019) Submandibular gland invasion by oral cavity cancers: a systemic review. Otolaryngol Head Neck Surg 161:227–234CrossRefPubMed Dundar Y, Mandle Q, Raza SN, Lin HS, Cramer J, Hotaling JM (2019) Submandibular gland invasion by oral cavity cancers: a systemic review. Otolaryngol Head Neck Surg 161:227–234CrossRefPubMed
18.
Zurück zum Zitat Chen TC, Lo WC, Ko JY, Lou PJ, Yang TL, Wang CP (2009) Rare involvement of submandibular gland by oral squamous cell carcinoma. Head Neck 31:877–881CrossRefPubMed Chen TC, Lo WC, Ko JY, Lou PJ, Yang TL, Wang CP (2009) Rare involvement of submandibular gland by oral squamous cell carcinoma. Head Neck 31:877–881CrossRefPubMed
19.
Zurück zum Zitat Malik A, Joshi P, Mishra A, Garg A, Mair M, Chakrabarti S, Nair S, Nair D, Chaturvedi P (2016) Prospective study of pattern of lymphatic metastasis in relation to submandibular gland in patients with carcinoma of oral cavity. Head Neck 38:1703–1707CrossRefPubMed Malik A, Joshi P, Mishra A, Garg A, Mair M, Chakrabarti S, Nair S, Nair D, Chaturvedi P (2016) Prospective study of pattern of lymphatic metastasis in relation to submandibular gland in patients with carcinoma of oral cavity. Head Neck 38:1703–1707CrossRefPubMed
20.
Zurück zum Zitat Takes RP, Robbins KT, Woolgar JA et al (2011) Questionable necessity to remove submandibular gland in neck dissection. Head Neck 33:743–745CrossRefPubMed Takes RP, Robbins KT, Woolgar JA et al (2011) Questionable necessity to remove submandibular gland in neck dissection. Head Neck 33:743–745CrossRefPubMed
21.
Zurück zum Zitat Nair D, Mair M, Singhvi H, Mishra A, Nair S, Agrawal J et al (2018) Perineural invasion: independent prognostic factor in oral cancer that warrants adjuvant treatment. Head Neck 40:1780–1787PubMed Nair D, Mair M, Singhvi H, Mishra A, Nair S, Agrawal J et al (2018) Perineural invasion: independent prognostic factor in oral cancer that warrants adjuvant treatment. Head Neck 40:1780–1787PubMed
22.
Zurück zum Zitat Chen TC, Lou PJ, Ko JY, Yang TL, Lo WC, Hu YL et al (2011) Feasibility of submandibular gland during neck dissection in patients with early stage oral cancer. Ann Surg Oncol 18:497–504CrossRefPubMed Chen TC, Lou PJ, Ko JY, Yang TL, Lo WC, Hu YL et al (2011) Feasibility of submandibular gland during neck dissection in patients with early stage oral cancer. Ann Surg Oncol 18:497–504CrossRefPubMed
23.
Zurück zum Zitat Du W, Fang Q, Liu S, Chen D, Luo R, Zhang X (2020) Feasibility of Submandibular Gland Preservation in cT1-2N0 squamous cell carcinoma in the floor of the Mouth. Front Oncol 10:579CrossRefPubMedPubMedCentral Du W, Fang Q, Liu S, Chen D, Luo R, Zhang X (2020) Feasibility of Submandibular Gland Preservation in cT1-2N0 squamous cell carcinoma in the floor of the Mouth. Front Oncol 10:579CrossRefPubMedPubMedCentral
Metadaten
Titel
Submandibular Gland in Neck Dissection: Necessary Fatality or Unfortunate Prey?
verfasst von
Tashnin Rahman
Kirti Khandelwal
Srinivas Bannoth
Ashok Kumar Das
Rajjyoti Das
Kishore Das
Anupam Das
Kaberi Kakati
Publikationsdatum
21.01.2023
Verlag
Springer India
Erschienen in
Indian Journal of Otolaryngology and Head & Neck Surgery / Ausgabe 2/2023
Print ISSN: 2231-3796
Elektronische ISSN: 0973-7707
DOI
https://doi.org/10.1007/s12070-023-03478-x

Weitere Artikel der Ausgabe 2/2023

Indian Journal of Otolaryngology and Head & Neck Surgery 2/2023 Zur Ausgabe

Betalaktam-Allergie: praxisnahes Vorgehen beim Delabeling

16.05.2024 Pädiatrische Allergologie Nachrichten

Die große Mehrheit der vermeintlichen Penicillinallergien sind keine. Da das „Etikett“ Betalaktam-Allergie oft schon in der Kindheit erworben wird, kann ein frühzeitiges Delabeling lebenslange Vorteile bringen. Ein Team von Pädiaterinnen und Pädiatern aus Kanada stellt vor, wie sie dabei vorgehen.

Eingreifen von Umstehenden rettet vor Erstickungstod

15.05.2024 Fremdkörperaspiration Nachrichten

Wer sich an einem Essensrest verschluckt und um Luft ringt, benötigt vor allem rasche Hilfe. Dass Umstehende nur in jedem zweiten Erstickungsnotfall bereit waren, diese zu leisten, ist das ernüchternde Ergebnis einer Beobachtungsstudie aus Japan. Doch es gibt auch eine gute Nachricht.

Real-World-Daten sprechen eher für Dupilumab als für Op.

14.05.2024 Rhinosinusitis Nachrichten

Zur Behandlung schwerer Formen der chronischen Rhinosinusitis mit Nasenpolypen (CRSwNP) stehen seit Kurzem verschiedene Behandlungsmethoden zur Verfügung, darunter Biologika, wie Dupilumab, und die endoskopische Sinuschirurgie (ESS). Beim Vergleich der beiden Therapieoptionen war Dupilumab leicht im Vorteil.

Schwindelursache: Massagepistole lässt Otholiten tanzen

14.05.2024 Benigner Lagerungsschwindel Nachrichten

Wenn jüngere Menschen über ständig rezidivierenden Lagerungsschwindel klagen, könnte eine Massagepistole der Auslöser sein. In JAMA Otolaryngology warnt ein Team vor der Anwendung hochpotenter Geräte im Bereich des Nackens.

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.