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Erschienen in: Journal of Cancer Research and Clinical Oncology 9/2009

01.09.2009 | Original Paper

Substantially reduced expression of PIAS1 is associated with colon cancer development

verfasst von: Domenico Coppola, Vevek Parikh, David Boulware, George Blanck

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 9/2009

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Abstract

Purpose

Protein inhibitors of activated STATs (PIAS) regulate the interferon-gamma (IFN-γ) signaling pathway, which has numerous effects on tumor development and tumor cell biology. PIAS’s also regulate STAT family members not directly involved in IFN-γ signaling. This project was designed to assess PIAS1 expression in colon cancer.

Methods

To determine whether PIAS1, one of the PIAS family members, or IFN-γ signaling pathway components could be used to stratify colon tumors, we stained tissue microarrays for PIAS1, interferon regulatory factor-1 (IRF-1) and STAT1α.

Results

PIAS1 staining of the colon cancer tissue microarrays indicated a strong correlation of normal colon cells, and adenomas, with high expression of both PIAS1 and IRF-1.

Conclusion

The PIAS1 results in particular may represent a basis for new approaches for efficiently distinguishing adenomas from colon cancer.
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Metadaten
Titel
Substantially reduced expression of PIAS1 is associated with colon cancer development
verfasst von
Domenico Coppola
Vevek Parikh
David Boulware
George Blanck
Publikationsdatum
01.09.2009
Verlag
Springer-Verlag
Erschienen in
Journal of Cancer Research and Clinical Oncology / Ausgabe 9/2009
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-009-0570-z

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