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26.04.2023 | Case Report

Synchronous gastric MALT lymphoma and gastric adenocarcinoma of fundic gland type arising from a hamartomatous inverted polyp in a Helicobacter pylori naive patient

verfasst von: Ryo Miyamoto, Hidehiko Takigawa, Takahiro Kotachi, Hiroki Kadota, Ryo Yuge, Ryohei Hayashi, Yuji Urabe, Akira Ishikawa, Kazuhiro Sentani, Shiro Oka

Erschienen in: Clinical Journal of Gastroenterology | Ausgabe 4/2023

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Abstract

We present a rare case that showed the coexistence of gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma in Helicobacter pylori-naive stomach. A 72-year-old man was followed up after surgery for epithelial carcinoma of the glottis at the Department of Otolaryngology. He underwent an upper gastrointestinal endoscopy for an abnormal PET-CT accumulation, which revealed gastric adenocarcinoma of fundic gland type in the gastric fundus and MALT lymphoma in the upper gastric body. Hence, we performed an endoscopic submucosal dissection for gastric cancer and diagnosed gastric adenocarcinoma of fundic gland type derived from a hamartomatous–inverted polyp. Subsequently, Gastric MALT lymphoma was treated with radiation therapy because the API2-MALT1 gene was positive and the Helicobacter pylori infection was negative. A complete response was observed. Even in Hp-naive stomachs, cases such as the present case are complicated by special types of gastric cancer and MALT lymphoma, and endoscopic examination should be performed with these diseases in mind.

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Titel: Synchronous gastric MALT lymphoma and gastric adenocarcinoma of fundic gland type arising from a hamartomatous inverted polyp in a Helicobacter pylori naive patient
verfasst von: Ryo Miyamoto
Hidehiko Takigawa
Takahiro Kotachi
Hiroki Kadota
Ryo Yuge
Ryohei Hayashi
Yuji Urabe
Akira Ishikawa
Kazuhiro Sentani
Shiro Oka
Publikationsdatum: 26.04.2023
Verlag: Springer Nature Singapore
Erschienen in: Clinical Journal of Gastroenterology / Ausgabe 4/2023
Print ISSN: 1865-7257
Elektronische ISSN: 1865-7265
DOI: https://doi.org/10.1007/s12328-023-01808-8

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