The online version of this article (doi:10.1186/1475-2875-11-323) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
RJM conceived of and designed the study, analysed the data and drafted the manuscript. RJM, SKP, WR, NV and RRM collected and entered the data. MUH, MAH, AAS, WR, AG, RA, RS, EBY, MGH and AMF provided clinical care for the patients. All authors read and approved the final manuscript.
Epidemiological data on malaria in Bangladesh are sparse, particularly on severe and fatal malaria. This hampers the allocation of healthcare provision in this resource-poor setting. Over 85% of the estimated 150,000-250,000 annual malaria cases in Bangladesh occur in Chittagong Division with 80% in the Chittagong Hill Tracts (CHT). Chittagong Medical College Hospital (CMCH) is the major tertiary referral hospital for severe malaria in Chittagong Division.
Malaria screening data from 22,785 inpatients in CMCH from 1999–2011 were analysed to investigate the patterns of referral, temporal trends and geographical distribution of severe malaria in Chittagong Division, Bangladesh.
From 1999 till 2011, 2,394 malaria cases were admitted, of which 96% harboured Plasmodium falciparum and 4% Plasmodium vivax. Infection was commonest in males (67%) between 15 and 34 years of age. Seasonality of malaria incidence was marked with a single peak in P. falciparum transmission from June to August coinciding with peak rainfall, whereas P. vivax showed an additional peak in February-March possibly representing relapse infections. Since 2007 there has been a substantial decrease in the absolute number of admitted malaria cases. Case fatality in severe malaria was 18% from 2008–2011, remaining steady during this period.
A travel history obtained in 226 malaria patients revealed only 33% had been to the CHT in the preceding three weeks. Of all admitted malaria patients, only 9% lived in the CHT, and none in the more remote malaria endemic regions near the Indian border.
The overall decline in admitted malaria cases to CMCH suggests recent control measures are successful. However, there are no reliable data on the incidence of severe malaria in the CHT, the most endemic area of Bangladesh, and most of these patients do not reach tertiary health facilities. Improvement of early treatment and simple supportive care for severe malaria in remote areas and implementation of a referral system for cases requiring additional supportive care could be important contributors to further reducing malaria-attributable disease and death in Bangladesh.
Additional file 1: Video 1. Map of annual number of cases of P. falciparum by area of residence from 2002–2011. Before 2008, data on Thana of residence were not available for those from the CHT. (Best viewed using QuickTime player (Apple Inc., CA, USA)). (AVI 3 MB)12936_2012_2573_MOESM1_ESM.avi
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Maude RJ, Dondorp AM, Faiz MA, Yunus EB, Samad R, Hossain A, Rahman MR: Malaria in southeast Bangladesh: a descriptive study. Bangladesh Med Res Counc Bull. 2008, 34: 87-89. PubMed
World Health Organization: World malaria report: Bangladesh. 2008, http://www.who.int/malaria/publications/country-profiles/2008/mal2008-bangladesh-en.pdf,
World Health Organization: Country profile world malaria report: Bangladesh. 2009, http://www.who.int/malaria/publications/country-profiles/2009/mal2009_bangladesh_0012.pdf,
Malaria and Parasitic Disease Control Unit, Directorate General of Health Services: Strategic Plan for Malaria Control Programme Bangladesh. 2008, http://www.nmcp.info/images/stories/documents/publications/Strategic%20Plan%202008-2015.pdf, –2015,
World Health Organization: Country profile world malaria report: Bangladesh. 2010, http://www.who.int/malaria/publications/country-profiles/profile_bgd_en.pdf,
Faiz MA, Yunus EB, Rahman MR, Hossain MA, Pang LW, Rahman ME, Bhuiyan SN: Failure of national guidelines to diagnose uncomplicated malaria in Bangladesh. Am J Trop Med Hyg. 2002, 67: 396-399. PubMed
Malaria and Parasitic Disease Control Unit: Annual Report. 2008, Bangladesh: Directorate General of Health Services, http://www.nmcp.info/images/stories/documents/publications/Annual_Report_08_09.pdf, July to May 2009. GFATM R-6 malaria Component, Bangladesh PR-GoB,
World Health Organization Regional Office for South-East Asia: Malaria situation in Bangladesh. 2006, http://www.searo.who.int/LinkFiles/Malaria_in_the_SEAR_BAN_mal06i.pdf,
World Health Organization Regional Office for South-East Asia: Malaria situation in SEAR countries. 2010, Bangladesh, http://www.searo.who.int/EN/section10/section21/section340_4015.htm,
World Health Organization: Guidelines for the treatment of malaria. 2010, http://whqlibdoc.who.int/publications/2010/9789241547925_eng.pdf, 2,
Malaria and Parasitic Disease Control Unit: The Diagnosis and Management of Severe Malaria Learner’s Guide. 2010, Bangladesh: Directorate General of Health Services, http://www.nmcp.info/documents/training/2_EDPT_SM.pdf,
Bangladesh Bureau of Statistics: Area, Population and Literacy Rate by Upazila/Thana-2001. http://www.bbs.gov.bd/dataindex/census/ce_uzila.pdf,
Bangladesh Bureau of Statistics: Bangladesh data sheet. 2010, http://www.bbs.gov.bd/dataindex/datasheet.xls,
Ahmed SM: Different health and health-seeking behaviours: ethnic minorities of the Chittagong Hill Tracts. Bangladesh. Asia Pacif J Public Health. 2001, 13: 100-10.1177/101053950101300208. CrossRef
Iyengar MOT: Seasonal incidence or tertian, subtertian and quartan infections. Ind J Med Res. 1932, 20: 303-
Roll Back Malaria: Bangladesh country profile. 2005, http://www.rollbackmalaria.org/wmr2005/profiles/bangladesh.pdf,
Gomes MF, Faiz MA, Gyapong JO, Warsame M, Agbenyega T, Babiker A, Baiden F, Yunus EB, Binka F, Clerk C, Folb P, Hassan R, Hossain MA, Kimbute O, Kitua A, Krishna S, Makasi C, Mensah N, Mrango Z, Olliaro P, Peto R, Peto TJ, Rahman MR, Ribeiro I, Samad R, White NJ, Study 13 Research Group: Pre-referral rectal artesunate to prevent death and disability in severe malaria: a placebo-controlled trial. Lancet. 2009, 373: 557-566. 10.1016/S0140-6736(08)61734-1. PubMedCentralCrossRefPubMed
- Temporal trends in severe malaria in Chittagong, Bangladesh
Richard James Maude
Mahtab Uddin Hasan
Md Amir Hossain
Abdullah Abu Sayeed
Sanjib Kanti Paul
Rapeephan Rattanawongnara Maude
Emran Bin Yunus
M Ridwanur Rahman
Abdul M Bangali
M Gofranul Hoque
Nicholas PJ Day
Nicholas J White
Lisa J White
Arjen M Dondorp
M Abul Faiz
- BioMed Central
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