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03.01.2021 | Original Article

Teriparatide and exercise improve bone, skeletal muscle, and fat parameters in ovariectomized and tail-suspended rats

verfasst von: Chiaki Sato, Naohisa Miyakoshi, Yuji Kasukawa, Koji Nozaka, Hiroyuki Tsuchie, Itsuki Nagahata, Yusuke Yuasa, Kazunobu Abe, Hikaru Saito, Ryo Shoji, Yoichi Shimada

Erschienen in: Journal of Bone and Mineral Metabolism | Ausgabe 3/2021

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Abstract

Introduction

Although teriparatide (TPTD) and exercise may improve osteoporosis, muscle atrophy, and fat metabolism during ageing, the effects of treatment with a combination of TPTD and exercise on these factors remain unclear. Therefore, this study examined the effects of TPTD and exercise on bone, skeletal muscle, and fat in ovariectomized and tail-suspended rats.

Materials and methods

Seven-month-old female Wistar rats were ovariectomized and subjected to tail suspension. The rats were then randomized into one of the following four groups (n = 20/group) after 4 weeks: control group, treated with TPTD vehicle and no exercise; TPTD group (30 µg/kg TPTD, 3 days/week); Exercise group (treadmill at 12 m/min, 60 min/day, 5 days/week); and Combined group treated with TPTD and treadmill exercise. After 1 and 8 weeks of treatment, bone, skeletal muscle, and fat tissue parameters were evaluated.

Results

TPTD improved bone mineral density (BMD), bone structure, bone strength at the femoral metaphysis, and the percentage of skeletal muscle mass, and decreased the percentage of fat mass and the adipose volume in the bone marrow. Treadmill exercise increased BMD, bone strength of cancellous bone, and the percentage of skeletal muscle mass, and decreased the percentage of fat mass as seen on dual-energy X-ray absorptiometry. Furthermore, combined treatment significantly affected BMD, bone structure, and bone strength of cortical bone at the femoral diaphysis.

Conclusion

TPTD or treadmill exercise improved bone, skeletal muscle, and fat mass. Combination therapy with TPTD and exercise had synergistic effects on BMD, structure, and bone strength in ovariectomized, tail-suspended rats.

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Titel: Teriparatide and exercise improve bone, skeletal muscle, and fat parameters in ovariectomized and tail-suspended rats
verfasst von: Chiaki Sato
Naohisa Miyakoshi
Yuji Kasukawa
Koji Nozaka
Hiroyuki Tsuchie
Itsuki Nagahata
Yusuke Yuasa
Kazunobu Abe
Hikaru Saito
Ryo Shoji
Yoichi Shimada
Publikationsdatum: 03.01.2021
Verlag: Springer Singapore
Erschienen in: Journal of Bone and Mineral Metabolism / Ausgabe 3/2021
Print ISSN: 0914-8779
Elektronische ISSN: 1435-5604
DOI: https://doi.org/10.1007/s00774-020-01184-0

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