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Journal of Gastroenterology
Erschienen in: Journal of Gastroenterology 7/2017

22.05.2017 | Review

TGF-β in inflammatory bowel disease: a key regulator of immune cells, epithelium, and the intestinal microbiota

verfasst von: Sozaburo Ihara, Yoshihiro Hirata, Kazuhiko Koike

Erschienen in: Journal of Gastroenterology | Ausgabe 7/2017

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Abstract

Inflammatory bowel disease (IBD) is defined as chronic intestinal inflammation, and includes ulcerative colitis and Crohn’s disease. Multiple factors are involved in the pathogenesis of IBD, and the condition is characterized by aberrant mucosal immune reactions to intestinal microbes in genetically susceptible hosts. Transforming growth factor-β (TGF-β) is an immune-suppressive cytokine produced by many cell types and activated by integrins. Active TGF-β binds to its receptor and regulates mucosal immune reactions through the TGF-β signaling pathway. Dysregulated TGF-β signaling is observed in the intestines of IBD patients. TGF-β signal impairment in specific cell types, such as T-cells and dendritic cells, results in spontaneous colitis in mouse models. In addition, specific intestinal microbes contribute to immune homeostasis by modulating TGF-β production. In this review, we describe the role of TGF-β in intestinal immunity, focusing on immune cells, epithelium, and intestinal microbes. In addition, we present potential therapeutic strategies for IBD that target TGF-β.
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Metadaten
Titel
TGF-β in inflammatory bowel disease: a key regulator of immune cells, epithelium, and the intestinal microbiota
verfasst von
Sozaburo Ihara
Yoshihiro Hirata
Kazuhiko Koike
Publikationsdatum
22.05.2017
Verlag
Springer Japan
Erschienen in
Journal of Gastroenterology / Ausgabe 7/2017
Print ISSN: 0944-1174
Elektronische ISSN: 1435-5922
DOI
https://doi.org/10.1007/s00535-017-1350-1

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