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Graefe's Archive for Clinical and Experimental Ophthalmology

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06.06.2019 | Retinal Disorders

The association between cone density and visual function in the macula of patients with retinitis pigmentosa

verfasst von: Tomoko Ueda-Consolvo, Hironori Ozaki, Tomoko Nakamura, Toshihiko Oiwake, Atsushi Hayashi

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 9/2019

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Abstract

Purpose

We observed cone photoreceptors by using adaptive optics (AO) fundus camera and optical coherence tomography (OCT) in patients with retinitis pigmentosa (RP) and examined the correlations between cone photoreceptors and visual function over 2 years.

Methods

Six patients with RP were studied. All patients underwent measurement using best-corrected decimal visual acuity, OCT, a Humphrey Field Analyzer with the 10-2 test grid pattern, and AO. AO images of the foveal center were obtained using an rtx1™ AO fundus camera, and cone counting was performed at 0.5 mm from the foveal center.

Results

AO detected a decrease of cone density over 2 years in RP patients. However, visual acuity, foveal sensitivity, and photoreceptor thickness were not changed over the 2 years.

Conclusions

AO images showed a decrease in the number of foveal cone densities over 2 years in patients with RP. AO may shorten the period required to predict the RP progression rate.

Phelan JK, Bok D (2000) A brief review of retinitis pigmentosa and identified retinitis pigmentosa genes. Mol Vis 6:116–124PubMed

Hartong DT, Berson E, Tryja TP (2006) Retinitis pigmentosa. Lancet 368:1795–1809CrossRef

Hamel C (2006) Retinitis pigmentosa. BioMed Cent Orphanet J Rare Dis 1:40. https://doi.org/10.1186/1750-1172-1-40. CrossRef

Wright AF, Chakarova CF, Abd El-Aziz MM, Bhattacharya SS (2010) Photoreceptor degeneration:genetic and mechanistic dissection of a complex trait. Nat Rev Genet 11(4):273–284. https://doi.org/10.1038/nrg2717 CrossRefPubMed

Fischer MD, Fleischauer JC, Gillies MC, Sutter FK, Helbig H, Barthelmes D (2008) A new method to monitor visual field defects caused by photoreceptor degeneration by quantitative optical coherence tomography. Invest Ophthalmol Vis Sci 49:3617–3621CrossRefPubMed

Battu R, Khanna A, Hegde B, Berendschot TT, Grover S, Schouten JS (2015) Correlation of structure and function of the macula in patients with retinitis pigmentosa. Eye 29:895–901CrossRefPubMedPubMedCentral

Choi SS, Doble N, Hardy JL, Jones SM, Keltner JL, Olivier SS, Werner JS (2006) In vivo imaging of the photoreceptor mosaic in retinal dystrophies and correlations with visual function. Invest Ophthalmol Vis Sci 47:2080–2092CrossRefPubMedPubMedCentral

Tojo N, Nakamura T, Fuchizawa C, Oiwake T, Hayashi A (2013) Adaptive optics fundus images of cone photoreceptors in the macula of patients with retinitis pigmentosa. Clin Ophthalmol 7:203–210PubMedPubMedCentral

Ratnam K, Carroll J, Porco TC, Duncan JL, Roorda A (2013) Relationship between foveal cone structure and clinical measures of visual function in patients with inherited retinal degenerations. Invest Ophthalmol Vis Sci 54(8):5836–5847. https://doi.org/10.1167/iovs.13-12557 CrossRefPubMedPubMedCentral

10.

Makiyama Y, Ooto S, Hangai M, Takayama K, Uji A, Oishi A, Ogino K, Nakagawa S, Yoshimura N (2013) Macular cone abnormalities in retinitis pigmentosa with preserved central vision using adaptive optics scanning laser ophthalmoscopy. PLoS One 8(11):e79447–e72013. https://doi.org/10.1371/journal.pone.0079447. eCollectionCrossRefPubMedPubMedCentral

11.

Mengihi M, Lujan BJ, Zayit-Soudry S, Syed R, Porco TC, Bayabo K, Carroll J, Roorda A, Duncan JL (2015) Correlation of outer nuclear layer thickness with cone density values in patients with retinitis pigmentosa and healthy subjects. Invest Ophthalmol Vis Sci 56:372–381CrossRef

12.

Duncan JL, Zhang Y, Gandhi J, Nakanishi C, Othman M, Branham KE, Swaroop A, Roorda A (2007) High-resolution imaging with adaptive optics in patients with inherited retinal degeneration. Invest Ophthalmol Vis Sci 48(7):3283–3291CrossRefPubMed

13.

Georgiou M, Kalitzeos A, Patterson EJ, Dubra A, Carroll J, Michaelides M (2017) Adaptive optics imaging of inherited retinal diseases. Br J Ophthalmol 15. https://doi.org/10.1136/bjophthalmol-2017-311328.

14.

Sun LW, Johnson RD, Langlo CS, Cooper RF, Razeen MM, Russillo MC, Dubra A, Connor TB Jr, Han DP, Pennesi ME, Kay CN, Weinberg DV, Stepien KE, Carroll J (2016) Assessing photoreceptor structure in retinitis pigmentosa and usher syndrome. Invest Ophthalmol Vis Sci 57(6):2428–2442. https://doi.org/10.1167/iovs.15-18246 CrossRefPubMedPubMedCentral

15.

Ijima H (2012) Correlation between visual sensitivity loss and years affected for eyes with retinitis pigmentosa. Jpn J Ophthalmol 56(3):224–229CrossRef

16.

Rangaswamy NV, Patel HM, Locke KG, Hood DC, Birch DG (2010) A comparison of visual field sensitivity to photoreceptor thickness in retinitis pigmentosa. Invest Ophthalmol Vis Sci 51(8):4213–4219. https://doi.org/10.1167/iovs.09-4945 CrossRefPubMedPubMedCentral

17.

Cursio CA, Sloan KR, Kalina RE, Hendrickson AE (1990) Human photoreceptor topography. J Comp Neurol 292:497–523CrossRef

18.

Marc RE, Jones BW, Watt CB, Strettoi E (2003) Neural remodeling in retinal degeneration. Prog Retin Eye Res 22:607–655CrossRefPubMed

19.

Wolsley CJ, Silvestri O’NJ, Saunders KJ, Anderson RS (2009) The association between multifocal electroretinograms and OCT retinal thickness in retinitis pigmentosa patients with good visual acuity. Eye 23:1524–1531CrossRefPubMed

Titel: The association between cone density and visual function in the macula of patients with retinitis pigmentosa
verfasst von: Tomoko Ueda-Consolvo
Hironori Ozaki
Tomoko Nakamura
Toshihiko Oiwake
Atsushi Hayashi
Publikationsdatum: 06.06.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 9/2019
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-019-04385-0

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The association between cone density and visual function in the macula of patients with retinitis pigmentosa

Abstract

Purpose

Methods

Results

Conclusions

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Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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