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Journal of Neural Transmission

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06.02.2017 | Neurology and Preclinical Neurological Studies - Review Article

The calretinin interneurons of the striatum: comparisons between rodents and primates under normal and pathological conditions

verfasst von: S. Petryszyn, A. Parent, Martin Parent

Erschienen in: Journal of Neural Transmission | Ausgabe 3/2018

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Abstract

This paper reviews the major organizational features of calretinin interneurons in the dorsal striatum of rodents and primates, with some insights on the state of these neurons in Parkinson’s disease and Huntington’s chorea. The rat striatum harbors medium-sized calretinin-immunoreactive (CR⁺) interneurons, whereas the mouse striatum is pervaded by medium-sized CR⁺ interneurons together with numerous small and highly immunoreactive CR⁺ cells. The CR interneuronal network is even more elaborated in monkey and human striatum where, in addition to the small- and medium-sized CR⁺ interneurons, a set of large CR⁺ interneurons occurs. The majority of these giant CR⁺ interneurons, which are unique to the primate striatum, also display immunoreactivity for choline acetyltransferase (ChAT), a faithful marker of cholinergic neurons. The expression of CR and/or ChAT by the large striatal interneurons appears to be seriously compromised in Parkinson’s disease and Huntington’s chorea. The species differences noted above have to be considered to better understand the role of CR interneurons in striatal organization in both normal and pathological conditions.

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Titel: The calretinin interneurons of the striatum: comparisons between rodents and primates under normal and pathological conditions
verfasst von: S. Petryszyn
A. Parent
Martin Parent
Publikationsdatum: 06.02.2017
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 3/2018
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-017-1687-x

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