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Arthritis Research & Therapy
Erschienen in: Arthritis Research & Therapy 1/2010

01.02.2010 | Review

The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis

verfasst von: Lisa C Willcocks, Paul A Lyons, Andrew J Rees, Kenneth GC Smith

Erschienen in: Arthritis Research & Therapy | Ausgabe 1/2010

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Abstract

The aetiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis has not been well defined. Here we review two factors which may play a role in the pathogenesis of the disease: genetics and infection. In particular, we discuss the role of autoantibodies to LAMP-2, which may arise following infection with Gram-negative bacteria, and may contribute to the development of ANCA-associated systemic vasculitis in genetically susceptible individuals.
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Metadaten
Titel
The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis
verfasst von
Lisa C Willcocks
Paul A Lyons
Andrew J Rees
Kenneth GC Smith
Publikationsdatum
01.02.2010
Verlag
BioMed Central
Erschienen in
Arthritis Research & Therapy / Ausgabe 1/2010
Elektronische ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2928

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