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Clinical Rheumatology

Erschienen in:

30.07.2022 | Original Article

The correlation of plasma atherogenic index and obesity in patients with familial Mediterranean fever

verfasst von: Hasan Göğebakan, Kamber Kaşali

Erschienen in: Clinical Rheumatology | Ausgabe 11/2022

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Abstract

Background

The plasma atherogenic index (PAI) is associated with cardiovascular diseases. This study evaluated the relationship between PAI and obesity in patients with familial Mediterranean fever (FMF) and its advantage over conventional lipid components in predicting obesity.

Methods

The cross-sectional study included 164 FMF patients in the attack-free period and a control group of 160 healthy individuals. Serum lipid components were measured, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). PAI was calculated as log 10 (TG/HDL-C). The relationship between PAI, four conventional lipid profiles, and obesity was evaluated.

Results

The mean PAI values (p = 0.003), frequency of obesity (p = 0.005), TC (p = 0.008), TG (p = 0.000), and LDL-C (p = 0.005) values were determined to be statistically significantly higher in the FMF patients than in the control group. The FMF patients with a higher PAI value had a higher risk of obesity, systolic and diastolic blood pressure, TC, and LDL-C, and lower HDL-C (p < 0.001). The Pearson coefficient for PAI (r = 0.854; p < 0.001) was calculated as an explanatory percentage on the variable of obesity of r² = 0.730. There was a stronger relationship between obesity and PAI than conventional lipid components (p < 0.001).

Conclusion

We have found that the PAI, BMI, TC, TG, and LDL-C values of the FMF patients were determined to be higher. The higher PAI was strongly correlated to obesity in FMF patients. The first time in FMF patients, PAI showed increased sensitivity to predict obesity, higher than conventional lipid components. It can be a promising biomarker for obesity compared to other lipid components. A low-cost and readily available index derived from routine (TG and HDL-C) tests are advantages in identifying obesity in FMF patients.

Key Points

• The PAI is valuable for atherosclerotic CVD risk management in patients with rheumatismal diseases.

• A correlation is found between PAI level and obesity, and it is used as a biomarker for obesity in the healthy population.

• The PAI revealed increased sensitivity to predict obesity, higher than conventional lipid components in FMF patients.

Alghamdi M (2017) Familial Mediterranean fever, review of the literature. Clin Rheumatol 36(8):1707–1713. https://doi.org/10.1007/s10067-017-3715-5CrossRefPubMed

Ben-Chetrit E, Levy M (1998) Familial Mediterranean fever. Lancet 351(9103):659–664. https://doi.org/10.1016/S0140-6736(97)09408-7CrossRefPubMed

Yüksel Ş, Ayvazyan L, Gasparyan AY (2010) Familial Mediterranean fever as an emerging clinical model of atherogenesis associated with low-grade ınflammation. Vol 4

Yuri Gasparyan A, Stavropoulos-Kalinoglou A, P (2010) Mikhailidis D, et al. The rationale for comparative studies of accelerated atherosclerosis in rheumatic diseases. Curr Vasc Pharmacol. 8(4):437–449

Icli A, Cure E, Cure MC et al (2016) Endocan levels and subclinical atherosclerosis in patients with systemic lupus erythematosus. Angiology 67(8):749–755CrossRef

Babaoglu H, Berkan Armagan B, Bodakci E et al (2021) Predictors of persistent inflammation in familial Mediterranean fever and association with damage. Rheumatology (Oxford) 60(1):333–339CrossRef

Cani PD, Amar J, Iglesias MA et al (2007) Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56(7):1761–1772. https://doi.org/10.2337/db06-1491CrossRefPubMed

Aballay LR, Eynard AR, Díaz M del P, Navarro A, Muñoz SE (2013) Overweight and obesity: a review of their relationship to metabolic syndrome, cardiovascular disease, and cancer in South America. Nutr Rev. 71(3):168–179. https://doi.org/10.1111/j.1753-4887.2012.00533.x

Bays HE, Toth PP, Kris-Etherton PM et al (2013) Obesity, adiposity, and dyslipidemia: a consensus statement from the National Lipid Association. J Clin Lipidol 7(4):304–383. https://doi.org/10.1016/j.jacl.2013.04.001CrossRefPubMed

10.

Nishide R, Ando M, Funabashi H, Yoda Y, Nakano M, Shima M (2015) Association of serum hs-CRP and lipids with obesity in school children in a 12-month follow-up study in Japan. Environ Health Prev Med 20(2):116–122. https://doi.org/10.1007/s12199-014-0433-3CrossRefPubMed

11.

Skinner AC, Perrin EM, Moss LA, Skelton JA (2015) Cardiometabolic risks and severity of obesity in children and young adults. N Engl J Med 373(14):1307–1317. https://doi.org/10.1056/NEJMoa1502821CrossRefPubMed

12.

Dobiášová M, Frohlich J (2001) The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate inapob-lipoprotein-depleted plasma (FERHDL). Clin Biochem 34(7):583–588. https://doi.org/10.1016/S0009-9120(01)00263-6CrossRefPubMed

13.

Bora K, Pathak MS, Borah P, et al. Association of the apolipoprotein A-1 gene polymorphisms with cardiovascular disease risk factors and atherogenic, indices in patients from Assam, Northeast India. 20(1):2017–2059. https://doi.org/10.1515/bjmg-2017-0002

14.

Yang SH, Du Y, Li XL et al (2017) Triglyceride to high-density lipoprotein cholesterol ratio and cardiovascular events in diabetics with coronary artery disease. Am J Med Sci 354(2):117–124. https://doi.org/10.1016/j.amjms.2017.03.032CrossRefPubMed

15.

Cai G, Shi G, Xue S, Lu W (2017) The atherogenic index of plasma is a strong and independent predictor for coronary artery disease in the Chinese Han population. Med (United States). 96(37). https://doi.org/10.1097/MD.0000000000008058

16.

Li WY, Kao TW, Chang PK et al (2021) Atherogenic index of plasma as predictors for metabolic syndrome, hypertension and diabetes mellitus in Taiwan citizens: a 9-year longitudinal study. Sci Rep 11(1):9900CrossRef

17.

Whang L, Chen F, Xiaoqi C et al (2021) Atherogenic ındex of plasma ıs an ındependent risk factor for coronary artery disease and a higher SYNTAX score. Angiology 72(2):181–186CrossRef

18.

Peters MJL, Symmons DPM, McCarey D et al (2010) EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis. Ann Rheum Dis 69(2):325–331. https://doi.org/10.1136/ard.2009.113696CrossRefPubMed

19.

Zhu X, Yu L, Zhou H et al (2018) Atherogenic index of plasma is a novel and better biomarker associated with obesity: a population-based cross-sectional study in China. Lipids Health Dis 17(1):37. https://doi.org/10.1186/s12944-018-0686-8CrossRefPubMedPubMedCentral

20.

Shen SW, Lu Y, Li F et al (2018) Atherogenic index of plasma is an effective index for estimating abdominal obesity. Lipids Health Dis 17(1):1–6. https://doi.org/10.1186/s12944-018-0656-1CrossRef

21.

Livneh A, Langevitz P, Zemer D et al (1997) Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum 40(10):1879–1885. https://doi.org/10.1002/art.1780401023CrossRefPubMed

22.

Shen SW, Lu Y, Li F et al (2015) Potential long-term effects of previous schistosome infection may reduce the atherogenic index of plasma in Chinese men. Int J Parasitol 45(5):289–294. https://doi.org/10.1016/j.ijpara.2015.01.001CrossRefPubMed

23.

Akbas EM, Timuroglu A, Ozcicek A, et al (2014) Association of uric acid, atherogenic ındex of plasma and albuminuria in diabetes mellitus. Vol 7. Accessed March 24, 2020. www.ijcem.com/

24.

Gendelman O, Shapira R, Tiosano S et al (2020) Familial Mediterranean fever is associated with increased risk for ischaemic heart disease and mortality–Perspective derived from a large database. Int J Clin Pract 74(5):e13473. https://doi.org/10.1111/ijcp.13473CrossRefPubMed

25.

Aune D, Sen A, Prasad M, et al (2016) BMI and all cause mortality: systematic review and non-linear dose-response meta-analysis of 230 cohort studies with 3.74 million deaths among 30.3 million participants. BMJ. 353. https://doi.org/10.1136/bmj.i2156

26.

Okorodudu DO, Jumean MF, Montori VM et al (2010) Diagnostic performance of body mass index to identify obesity as defined by body adiposity: a systematic review and meta-analysis. Int J Obes 34(5):791–799. https://doi.org/10.1038/ijo.2010.5CrossRef

27.

Bozkurt E, Kaya F, Ertürk A et al (2021) Is visceral adipose tissue or subcutaneous adipose tissue a risk factor for atherosclerotic heart disease in familial mediterranean fever? Medicine Science 10(3):890–894CrossRef

28.

Millán J, Pintó X, Muñoz A et al (2009) Lipoprotein ratios: physiological significance and clinical usefulness in cardiovascular prevention. Vasc Health Risk Manag 5:757–765. https://doi.org/10.2147/vhrm.s6269CrossRefPubMedPubMedCentral

29.

Zhu XW, Deng FY, Lei SF (2015) Meta-analysis of atherogenic ındex of plasma and other lipid parameters in relation to risk of type 2 diabetes mellitus. Prim Care Diabetes 9(1):60–67. https://doi.org/10.1016/j.pcd.2014.03.007CrossRefPubMed

30.

Gaziano JM, Hennekens CH, O’Donnell CJ, Breslow JL, Buring JE (1997) Fasting triglycerides, high-density lipoprotein, and risk of myocardial infarction. Circulation 96(8):2520–2525. https://doi.org/10.1161/01.CIR.96.8.2520CrossRefPubMed

31.

Lachmann HJ, Sengül B, Yavuzşen TU et al (2006) Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations. Rheumatology (Oxford) 45(6):746–750CrossRef

32.

Notarnicola C, Didelot MN, Seguret F, Demaille J, Touitou I (2002) Enhanced cytokine mRNA levels in attack-free patients with familial Mediterranean fever. Genes Immun 3(1):43–45. https://doi.org/10.1038/sj.gene.6363813CrossRefPubMed

33.

Cure E, Icli A, Ugur Uslu A et al (2017) Atherogenic index of plasma may be strong predictor of subclinical atherosclerosis in patients with Behçet disease. Z Rheumatol 76(3):259–266. https://doi.org/10.1007/s00393-016-0141-zCrossRefPubMed

34.

Icli A, Cure E, Uslu AU et al (2017) The relationship between atherogenic ındex and carotid artery atherosclerosis in familial Mediterranean fever. Angiology 68(4):315–321. https://doi.org/10.1177/0003319716659220CrossRefPubMed

35.

Uslu AU, Kucuk A, Icli A et al (2017) Plazma aterojenik ındeks, sistemik lupus eritematozusunda subklinik aterosklerozun bağimsiz bir göstergedir. Eurasian J Med 49(3):193–197. https://doi.org/10.5152/eurasianjmed.2017.17143CrossRefPubMedPubMedCentral

36.

Parveen S, Jacob R, Rajasekhar L, Srinivasa C, Mohan IK (2017) Serum lipid alterations in early rheumatoid arthritis patients on disease modifying anti rheumatoid therapy. Indian J Clin Biochem 32(1):26–32. https://doi.org/10.1007/s12291-016-0566-9CrossRefPubMed

37.

Keles N (2016) Is triglyseride/ HDL ratio a reliable screening test for assesment of atherosclerotic risk in patients with chronic ınflammatory diseases? North Clin Istanbul 3(1):39. https://doi.org/10.14744/nci.2016.52824CrossRef

38.

Valero-Jaimes JA, López-González R, Martín-artínez MA (2021) Body mass ındex and disease activity in chronic ınflammatory rheumatic diseases: results of the cardiovascular in rheumatology (Carma) project. J Clin Med 10(3):382CrossRef

Titel: The correlation of plasma atherogenic index and obesity in patients with familial Mediterranean fever
verfasst von: Hasan Göğebakan
Kamber Kaşali
Publikationsdatum: 30.07.2022
Verlag: Springer International Publishing
Erschienen in: Clinical Rheumatology / Ausgabe 11/2022
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-022-06312-x

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Abstract

Background

Methods

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Conclusion

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