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01.02.2008

The Cough Reflex in Animals: Relevance to Human Cough Research

verfasst von: Brendan J. Canning

Erschienen in: Lung | Sonderheft 1/2008

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Abstract

All mammalian species studied cough or display some similar respiratory reflex upon aerosol challenge with tussigenic stimuli such as citric acid or capsaicin. Animals cough to the same stimuli that evoke coughing in humans, and therapeutic agents that display antitussive effects in human studies also prevent coughing in animals. The many invasive procedures and complementary in vitro studies possible in animals but not readily reproduced in human subjects, along with the proven predictive value of cough studies in animals, provide the rationale for animal modeling of human cough. The advantages and disadvantages of studying cough in animals are discussed.

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Titel: The Cough Reflex in Animals: Relevance to Human Cough Research
verfasst von: Brendan J. Canning
Publikationsdatum: 01.02.2008
Verlag: Springer-Verlag
Erschienen in: Lung / Ausgabe Sonderheft 1/2008
Print ISSN: 0341-2040
Elektronische ISSN: 1432-1750
DOI: https://doi.org/10.1007/s00408-007-9054-6

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