Skip to main content

28.04.2016 | Original Paper | Ausgabe 7/2016

AIDS and Behavior 7/2016

The Effect of Depressive Symptoms on Adherence to Daily Oral PrEP in Men who have Sex with Men and Transgender Women: A Marginal Structural Model Analysis of The iPrEx OLE Study

AIDS and Behavior > Ausgabe 7/2016
Megha L. Mehrotra, David V. Glidden, Vanessa McMahan, K. Rivet Amico, Sybil Hosek, Patricia Defechereux, Kenneth H. Mayer, Valdilea G. Veloso, Linda-Gail Bekker, Vivian I. Avelino-Silva, Mauro Schechter, Robert M. Grant


We assessed the role of depressive symptoms on adherence to daily oral FTC/TDF for HIV PrEP in cisgender men who have sex with men (MSM) and transgender women who have sex with men (TGW) using data from the iPrEx OLE study. A marginal structural logistic regression model was used to estimate the effect of time-varying CES-D scores on having protective levels of drug concentration, adjusting for confounding by sexual practices over time, prior adherence, and baseline demographic characteristics. We found a non-monotonic relationship between CES-D score and odds of protective FTC/TDF levels in MSM. We found evidence that the effect of depression on adherence varied between MSM and TGW, and that depressive symptoms did not contribute greatly to decreased adherence on a population scale. We recommend that depressive symptoms not preclude the prescription of PrEP, and that MSM and TGW be studied separately.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Premium-Inhalten der Fachzeitschriften, inklusive eines Print-Abos.

Jetzt abonnieren und bis 25. Juni einen 50 € Amazon-Gutschein sichern.

Über diesen Artikel

Weitere Artikel der Ausgabe 7/2016

AIDS and Behavior 7/2016Zur Ausgabe