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01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

BMC Pulmonary Medicine 1/2015

The effects of exercise training in a weight loss lifestyle intervention on asthma control, quality of life and psychosocial symptoms in adult obese asthmatics: protocol of a randomized controlled trial

Zeitschrift:
BMC Pulmonary Medicine > Ausgabe 1/2015
Autoren:
Patricia D. Freitas, Palmira G. Ferreira, Analuci da Silva, Sonia Trecco, Rafael Stelmach, Alberto Cukier, Regina Carvalho-Pinto, João Marcos Salge, Frederico LA Fernandes, Marcio C. Mancini, Milton A. Martins, Celso RF Carvalho
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

PDF: significant manuscript write and review, study concept and design; PGF: study concept and design, manuscript review; AS: psychological therapy concept and design, manuscript review; SMLT: nutritional therapy concept and design, manuscript review; RS: study concept and design, manuscript review; AC: study concept and design, manuscript review; RMCP: study concept and design, manuscript review; JMS: pulmonary function and cardiopulmonary exercise test support, manuscript review; FLAF: pulmonary function and cardiopulmonary exercise test support, manuscript review; MCM: study concept and design; bioelectrical impedance support, manuscript review; MAM: project supervision, manuscript review; CRFC: project supervision, manuscript write and review, study concept and design; overall study coordination. All authors have read and approved the final version of the manuscript.

Authors’ information

Not applicable.

Availability of data and materials

Not applicable.

Abstract

Background

Asthma and obesity are public health problems with increasing prevalence worldwide. Clinical and epidemiologic studies have demonstrated that obese asthmatics have worse clinical control and health related quality of life (HRQL) despite an optimized medical treatment. Bariatric surgery is successful to weight-loss and improves asthma control; however, the benefits of nonsurgical interventions remain unknown.

Methods/Design

This is a randomized controlled trial with 2-arms parallel. Fifty-five moderate or severe asthmatics with grade II obesity (BMI ≥ 35 kg/m2) under optimized medication will be randomly assigned into either weight-loss program + sham (WL + S group) or weight-loss program + exercise (WL + E group). The weight loss program will be the same for both groups including nutrition and psychological therapies (every 15 days, total of 6 sessions, 60 min each). Exercise program will include aerobic and resistance muscle training while sham treatment will include a breathing and stretching program (both programs twice a week, 3 months, 60 min each session). The primary outcome variable will be asthma clinical control. Secondary outcomes include HRQL, levels of depression and anxiety, lung function, daily life physical activity, body composition, maximal aerobic capacity, strength muscle and sleep disorders. Potential mechanism (changes in lung mechanical and airway/systemic inflammation) will also be examined to explain the benefits in both groups.

Discussion

This study will bring a significant contribution to the literature evaluating the effects of exercise conditioning in a weight loss intervention in obese asthmatics as well as will evaluate possible involved mechanisms.

Trial registration

Literatur
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