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Erschienen in: Current Heart Failure Reports 6/2022

13.10.2022 | Imaging in Heart Failure (J. Schulz-Menger, Section Editor)

The Electrocardiogram in the Diagnosis and Management of Patients With Left Ventricular Non-Compaction

verfasst von: Giuseppe D. Sanna, Anna Piga, Guido Parodi, Gianfranco Sinagra, Michael Papadakis, Antonis Pantazis, Sanjay Sharma, Sabiha Gati, Gherardo Finocchiaro

Erschienen in: Current Heart Failure Reports | Ausgabe 6/2022

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Abstract

Purpose of the Review

Left ventricular non-compaction (LVNC) is characterised by prominent left ventricular trabeculae and deep inter-trabecular recesses. Although considered a distinct cardiomyopathy, prominent trabeculations may also be found in other cardiomyopathies, in athletes or during pregnancy. Clinical presentation includes heart failure symptoms, systemic embolic events, arrhythmias and sudden cardiac death. Currently, LVNC diagnosis relies on imaging criteria, and clinicians face several challenges in the assessment of patients with prominent trabeculations. In this review, we summarise the available information on the role of the ECG in the diagnosis and management of LVNC.

Recent Findings

ECG abnormalities have been reported in 75–94% of adults and children with LVNC. The lack of specificity of these ECG abnormalities does not allow (in isolation) to diagnose the condition. However, when considered in a set of diagnostic criteria including family history, clinical information, and imaging features, the ECG may differentiate between physiological and pathological findings or may provide clues raising the possibility of specific underlying conditions. Finally, some ECG features in LVNC constitute ominous signs that require a stricter patient surveillance or specific therapeutic measures.

Summary

The ECG remains a cornerstone in the diagnosis and management of patients with cardiomyopathies, including LVNC.
Literatur
1.
Zurück zum Zitat Elliott P, Andersson B, Arbustini E, Bilinska Z, Cecchi F, Charron P, et al. Classification of the cardiomyopathies: a position statement from the European Society Of Cardiology Working Group on myocardial and pericardial diseases. Eur Heart J. 2008;29(2):270–6.PubMedCrossRef Elliott P, Andersson B, Arbustini E, Bilinska Z, Cecchi F, Charron P, et al. Classification of the cardiomyopathies: a position statement from the European Society Of Cardiology Working Group on myocardial and pericardial diseases. Eur Heart J. 2008;29(2):270–6.PubMedCrossRef
2.
Zurück zum Zitat Maron BJ, Towbin JA, Thiene G, Antzelevitch C, Corrado D, Arnett D, et al. Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; quality of care and outcomes research and function. Circulation. 2006;113(14):1807–16.PubMedCrossRef Maron BJ, Towbin JA, Thiene G, Antzelevitch C, Corrado D, Arnett D, et al. Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; quality of care and outcomes research and function. Circulation. 2006;113(14):1807–16.PubMedCrossRef
3.
Zurück zum Zitat Kohli SK, Pantazis AA, Shah JS, Adeyemi B, Jackson G, McKenna WJ, et al. Diagnosis of left-ventricular non-compaction in patients with left-ventricular systolic dysfunction: time for a reappraisal of diagnostic criteria? Eur Heart J. 2008;29(1):89–95.PubMedCrossRef Kohli SK, Pantazis AA, Shah JS, Adeyemi B, Jackson G, McKenna WJ, et al. Diagnosis of left-ventricular non-compaction in patients with left-ventricular systolic dysfunction: time for a reappraisal of diagnostic criteria? Eur Heart J. 2008;29(1):89–95.PubMedCrossRef
4.
Zurück zum Zitat Oechslin E, Jenni R. Left ventricular non-compaction revisited: a distinct phenotype with genetic heterogeneity? Eur Heart J. 2011;32(12):1446–56.PubMedCrossRef Oechslin E, Jenni R. Left ventricular non-compaction revisited: a distinct phenotype with genetic heterogeneity? Eur Heart J. 2011;32(12):1446–56.PubMedCrossRef
5.
Zurück zum Zitat Gati S, Chandra N, Bennett RL, Reed M, Kervio G, Panoulas VF, et al. Increased left ventricular trabeculation in highly trained athletes: do we need more stringent criteria for the diagnosis of left ventricular non-compaction in athletes? Heart. 2013;99(6):401–8.PubMedCrossRef Gati S, Chandra N, Bennett RL, Reed M, Kervio G, Panoulas VF, et al. Increased left ventricular trabeculation in highly trained athletes: do we need more stringent criteria for the diagnosis of left ventricular non-compaction in athletes? Heart. 2013;99(6):401–8.PubMedCrossRef
6.
Zurück zum Zitat Moon JC, McKenna WJ. Myocardial crypts: a prephenotypic marker of hypertrophic cardiomyopathy? Circ Cardiovasc Imaging. 2012;5(4):431–2.PubMedCrossRef Moon JC, McKenna WJ. Myocardial crypts: a prephenotypic marker of hypertrophic cardiomyopathy? Circ Cardiovasc Imaging. 2012;5(4):431–2.PubMedCrossRef
7.
Zurück zum Zitat Zorzi A, Vio R, Bettella N, Corrado D. Criteria for interpretation of the athlete’s ECG: a critical appraisal. Pacing Clin Electrophysiol. 2020;43(8):882–90.PubMedCrossRef Zorzi A, Vio R, Bettella N, Corrado D. Criteria for interpretation of the athlete’s ECG: a critical appraisal. Pacing Clin Electrophysiol. 2020;43(8):882–90.PubMedCrossRef
8.
Zurück zum Zitat Gati S, Papadakis M, Papamichael ND, Zaidi A, Sheikh N, Reed M, et al. Reversible de novo left ventricular trabeculations in pregnant women: implications for the diagnosis of left ventricular noncompaction in low-risk populations. Circulation. 2014;130(6):475–83.PubMedCrossRef Gati S, Papadakis M, Papamichael ND, Zaidi A, Sheikh N, Reed M, et al. Reversible de novo left ventricular trabeculations in pregnant women: implications for the diagnosis of left ventricular noncompaction in low-risk populations. Circulation. 2014;130(6):475–83.PubMedCrossRef
9.
Zurück zum Zitat Captur G, Flett AS, Jacoby DL, Moon JC. Left ventricular non-noncompaction: the mitral valve prolapse of the 21st century? Int J Cardiol. 2013;164(1):3–6.PubMedCrossRef Captur G, Flett AS, Jacoby DL, Moon JC. Left ventricular non-noncompaction: the mitral valve prolapse of the 21st century? Int J Cardiol. 2013;164(1):3–6.PubMedCrossRef
10.
Zurück zum Zitat Elliott P, Charron P, Blanes JRG, Tavazzi L, Tendera M, Konté M, et al. European cardiomyopathy pilot registry: EURObservational research programme of the European society of cardiology. Eur Heart J. 2016;37(2):164–73.PubMedCrossRef Elliott P, Charron P, Blanes JRG, Tavazzi L, Tendera M, Konté M, et al. European cardiomyopathy pilot registry: EURObservational research programme of the European society of cardiology. Eur Heart J. 2016;37(2):164–73.PubMedCrossRef
11.
Zurück zum Zitat Nugent AW, Daubeney PEF, Chondros P, Carlin JB, Cheung M, Wilkinson LC, et al. The epidemiology of childhood cardiomyopathy in Australia. N Engl J Med. 2003;348(17):1639–46.PubMedCrossRef Nugent AW, Daubeney PEF, Chondros P, Carlin JB, Cheung M, Wilkinson LC, et al. The epidemiology of childhood cardiomyopathy in Australia. N Engl J Med. 2003;348(17):1639–46.PubMedCrossRef
12.
Zurück zum Zitat Captur G, Muthurangu V, Cook C, Flett AS, Wilson R, Barison A, et al. Quantification of left ventricular trabeculae using fractal analysis. J Cardiovasc Magn Reson. 2013;15(1):1–10.CrossRef Captur G, Muthurangu V, Cook C, Flett AS, Wilson R, Barison A, et al. Quantification of left ventricular trabeculae using fractal analysis. J Cardiovasc Magn Reson. 2013;15(1):1–10.CrossRef
13.
Zurück zum Zitat Chin TK, Perloff JK, Williams RG, Jue K, Mohrmann R. Isolated noncompaction of left ventricular myocardium. A study of eight cases Circulation. 1990;82(2):507–13.PubMed Chin TK, Perloff JK, Williams RG, Jue K, Mohrmann R. Isolated noncompaction of left ventricular myocardium. A study of eight cases Circulation. 1990;82(2):507–13.PubMed
14.
Zurück zum Zitat Ritter M, Oechslin E, Sütsch G, Attenhofer C, Schneider J, Jenni R. Isolated noncompaction of the myocardium in adults. Mayo Clin Proc. 1997;72(1):26–31.PubMedCrossRef Ritter M, Oechslin E, Sütsch G, Attenhofer C, Schneider J, Jenni R. Isolated noncompaction of the myocardium in adults. Mayo Clin Proc. 1997;72(1):26–31.PubMedCrossRef
15.
Zurück zum Zitat Ichida F, Hamamichi Y, Miyawaki T, Ono Y, Kamiya T, Akagi T, et al. Clinical features of isolated noncompaction of the ventricular myocardium. J Am Coll Cardiol. 1999;34(1):233–40.PubMedCrossRef Ichida F, Hamamichi Y, Miyawaki T, Ono Y, Kamiya T, Akagi T, et al. Clinical features of isolated noncompaction of the ventricular myocardium. J Am Coll Cardiol. 1999;34(1):233–40.PubMedCrossRef
16.
Zurück zum Zitat Oechslin EN, Attenhofer Jost CH, Rojas JR, Kaufmann PA, Jenni R. Long-term follow-up of 34 adults with isolated left ventricular noncompaction: a distinct cardiomyopathy with poor prognosis. J Am Coll Cardiol. 2000;36(2):493–500.PubMedCrossRef Oechslin EN, Attenhofer Jost CH, Rojas JR, Kaufmann PA, Jenni R. Long-term follow-up of 34 adults with isolated left ventricular noncompaction: a distinct cardiomyopathy with poor prognosis. J Am Coll Cardiol. 2000;36(2):493–500.PubMedCrossRef
17.
Zurück zum Zitat Ergul Y, Nisli K, Varkal MA, Oner N, Dursun M, Dindar A, et al. Electrocardiographic findings at initial diagnosis in children with isolated left ventricular noncompaction. Ann Noninvasive Electrocardiol. 2011;16(2):184–91.PubMedPubMedCentralCrossRef Ergul Y, Nisli K, Varkal MA, Oner N, Dursun M, Dindar A, et al. Electrocardiographic findings at initial diagnosis in children with isolated left ventricular noncompaction. Ann Noninvasive Electrocardiol. 2011;16(2):184–91.PubMedPubMedCentralCrossRef
18.
Zurück zum Zitat Pignatelli RH, McMahon CJ, Dreyer WJ, Denfield SW, Price J, Belmont JW, et al. Clinical characterization of left ventricular noncompaction in children: a relatively common form of cardiomyopathy. Circulation. 2003;108(21):2672–8.PubMedCrossRef Pignatelli RH, McMahon CJ, Dreyer WJ, Denfield SW, Price J, Belmont JW, et al. Clinical characterization of left ventricular noncompaction in children: a relatively common form of cardiomyopathy. Circulation. 2003;108(21):2672–8.PubMedCrossRef
19.
Zurück zum Zitat Stöllberger C, Gerger D, Wegner C, Finsterer J. Quantitative electrocardiographic measures, neuromuscular disorders, and survival in left ventricular hypertrabeculation/noncompaction. Ann Noninvasive Electrocardiol. 2013;18(3):251–5.PubMedPubMedCentralCrossRef Stöllberger C, Gerger D, Wegner C, Finsterer J. Quantitative electrocardiographic measures, neuromuscular disorders, and survival in left ventricular hypertrabeculation/noncompaction. Ann Noninvasive Electrocardiol. 2013;18(3):251–5.PubMedPubMedCentralCrossRef
20.
Zurück zum Zitat Brescia ST, Rossano JW, Pignatelli R, Jefferies JL, Price JF, Decker JA, et al. Mortality and sudden death in pediatric left ventricular noncompaction in a tertiary referral center. Circulation. 2013;127(22):2202–8.PubMedCrossRef Brescia ST, Rossano JW, Pignatelli R, Jefferies JL, Price JF, Decker JA, et al. Mortality and sudden death in pediatric left ventricular noncompaction in a tertiary referral center. Circulation. 2013;127(22):2202–8.PubMedCrossRef
21.
Zurück zum Zitat Towbin JA, Jefferies JL. Cardiomyopathies due to left ventricular noncompaction, mitochondrial and storage diseases, and inborn errors of metabolism. Circ Res. 2017;121(7):838–54.PubMedCrossRef Towbin JA, Jefferies JL. Cardiomyopathies due to left ventricular noncompaction, mitochondrial and storage diseases, and inborn errors of metabolism. Circ Res. 2017;121(7):838–54.PubMedCrossRef
23.
Zurück zum Zitat Gungor B, Alper AT, Celebi A, Bolca O. Sinus node dysfunction as the first manifestation of left ventricular noncompaction with multiple cardiac abnormalities. Indian Pacing Electrophysiol J. 2013;13(4):157–61.PubMedPubMedCentralCrossRef Gungor B, Alper AT, Celebi A, Bolca O. Sinus node dysfunction as the first manifestation of left ventricular noncompaction with multiple cardiac abnormalities. Indian Pacing Electrophysiol J. 2013;13(4):157–61.PubMedPubMedCentralCrossRef
24.
Zurück zum Zitat Tsai SF, Ebenroth ES, Hurwitz RA, Cordes TM, Schamberger MS, Batra AS. Is left ventricular noncompaction in children truly an isolated lesion? Pediatr Cardiol. 2009;30(5):597–602.PubMedCrossRef Tsai SF, Ebenroth ES, Hurwitz RA, Cordes TM, Schamberger MS, Batra AS. Is left ventricular noncompaction in children truly an isolated lesion? Pediatr Cardiol. 2009;30(5):597–602.PubMedCrossRef
25.
Zurück zum Zitat Towbin JA, Lorts A, Jefferies JL. Left ventricular non-compaction cardiomyopathy. Lancet. 2015;386(9995):813–25.PubMedCrossRef Towbin JA, Lorts A, Jefferies JL. Left ventricular non-compaction cardiomyopathy. Lancet. 2015;386(9995):813–25.PubMedCrossRef
26.
Zurück zum Zitat Domain G, Chouquet C, Réant P, Bongard V, Vedis T, Rollin A, et al. Relationships between left ventricular mass and QRS duration in diverse types of left ventricular hypertrophy. Eur Heart J Cardiovasc Imaging. 2022;23(4):560–8.PubMedCrossRef Domain G, Chouquet C, Réant P, Bongard V, Vedis T, Rollin A, et al. Relationships between left ventricular mass and QRS duration in diverse types of left ventricular hypertrophy. Eur Heart J Cardiovasc Imaging. 2022;23(4):560–8.PubMedCrossRef
28.•
Zurück zum Zitat Ekizler FA, Cay S, Ulvan N, Tekin Tak B, Cetin EHO, Kafes H, et al. Importance of lead aVR on predicting adverse cardiac events in patients with noncompaction cardiomyopathy. Ann Noninvasive Electrocardiol. 2020;25(3):212–23. In this study positive TaVR was superior to any other ECG findings in the establishment of patients with LVNC most at risk for adverse cardiac events.CrossRef Ekizler FA, Cay S, Ulvan N, Tekin Tak B, Cetin EHO, Kafes H, et al. Importance of lead aVR on predicting adverse cardiac events in patients with noncompaction cardiomyopathy. Ann Noninvasive Electrocardiol. 2020;25(3):212–23. In this study positive TaVR was superior to any other ECG findings in the establishment of patients with LVNC most at risk for adverse cardiac events.CrossRef
29.
Zurück zum Zitat Caliskan K, Ujvari B, Bauernfeind T, Theuns DAMJ, Van Domburg RT, Akca F, et al. The prevalence of early repolarization in patients with noncompaction cardiomyopathy presenting with malignant ventricular arrhythmias. J Cardiovasc Electrophysiol. 2012;23(9):938–44.PubMedCrossRef Caliskan K, Ujvari B, Bauernfeind T, Theuns DAMJ, Van Domburg RT, Akca F, et al. The prevalence of early repolarization in patients with noncompaction cardiomyopathy presenting with malignant ventricular arrhythmias. J Cardiovasc Electrophysiol. 2012;23(9):938–44.PubMedCrossRef
30.
Zurück zum Zitat Shoji M, Yamashita T, Uejima T, Asada K, Semba H, Otsuka T, et al. Electrocardiography characteristics of isolated non-compaction of ventricular myocardium in Japanese adult patients. Circ J. 2010;74(7):1431–5.PubMedCrossRef Shoji M, Yamashita T, Uejima T, Asada K, Semba H, Otsuka T, et al. Electrocardiography characteristics of isolated non-compaction of ventricular myocardium in Japanese adult patients. Circ J. 2010;74(7):1431–5.PubMedCrossRef
31.
Zurück zum Zitat Van Malderen S, Wijchers S, Akca F, Caliskan K, Szili-Torok T. Mismatch between the origin of premature ventricular complexes and the noncompacted myocardium in patients with noncompaction cardiomyopathy patients: involvement of the conduction system? Ann Noninvasive Electrocardiol. 2017;22(2):1–7. Van Malderen S, Wijchers S, Akca F, Caliskan K, Szili-Torok T. Mismatch between the origin of premature ventricular complexes and the noncompacted myocardium in patients with noncompaction cardiomyopathy patients: involvement of the conduction system? Ann Noninvasive Electrocardiol. 2017;22(2):1–7.
32.
Zurück zum Zitat Stöllberger C, Blazek G, Winkler-Dworak M, Finsterer J. Sex differences in left ventricular noncompaction in patients with and without neuromuscular disorders. Rev Española Cardiol (English Ed). 2008;61(2):130–6.CrossRef Stöllberger C, Blazek G, Winkler-Dworak M, Finsterer J. Sex differences in left ventricular noncompaction in patients with and without neuromuscular disorders. Rev Española Cardiol (English Ed). 2008;61(2):130–6.CrossRef
34.
Zurück zum Zitat Sedaghat-Hamedani F, Haas J, Zhu F, Geier C, Kayvanpour E, Liss M, et al. Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy. Eur Heart J. 2017;38(46):3449–60.PubMedCrossRef Sedaghat-Hamedani F, Haas J, Zhu F, Geier C, Kayvanpour E, Liss M, et al. Clinical genetics and outcome of left ventricular non-compaction cardiomyopathy. Eur Heart J. 2017;38(46):3449–60.PubMedCrossRef
35.
Zurück zum Zitat Salazar-Mendiguchía J, González-Costello J, Oliveras T, Gual F, Lupón J, Manito N. Long-term follow-up of symptomatic adult patients with noncompaction cardiomyopathy. Rev Española Cardiol (English Ed). 2019;72(2):169–71.CrossRef Salazar-Mendiguchía J, González-Costello J, Oliveras T, Gual F, Lupón J, Manito N. Long-term follow-up of symptomatic adult patients with noncompaction cardiomyopathy. Rev Española Cardiol (English Ed). 2019;72(2):169–71.CrossRef
37.
Zurück zum Zitat Negri F, De Luca A, Morea G, Ferro MD, Faganello G, Vitrella G, et al. Facciamo il punto: Miocardio non compatto. G Ital Cardiol. 2018;19(6):371–8. Negri F, De Luca A, Morea G, Ferro MD, Faganello G, Vitrella G, et al. Facciamo il punto: Miocardio non compatto. G Ital Cardiol. 2018;19(6):371–8.
38.
Zurück zum Zitat Li S, Zhang C, Liu N, Bai H, Hou C, Wang J, Song L, Pu J. Genotype-positive status is associated with poor prognoses in patients with left ventricular noncompaction cardiomyopathy. J Am Heart Assoc. 2018;7(20):e009910. Li S, Zhang C, Liu N, Bai H, Hou C, Wang J, Song L, Pu J. Genotype-positive status is associated with poor prognoses in patients with left ventricular noncompaction cardiomyopathy. J Am Heart Assoc. 2018;7(20):e009910.
39.
Zurück zum Zitat Postma AV, Van Engelen K, Van De Meerakker J, Rahman T, Probst S, Baars MJH, et al. Mutations in the sarcomere gene MYH7 in Ebstein anomaly. Circ Cardiovasc Genet. 2011;4(1):43–50.PubMedCrossRef Postma AV, Van Engelen K, Van De Meerakker J, Rahman T, Probst S, Baars MJH, et al. Mutations in the sarcomere gene MYH7 in Ebstein anomaly. Circ Cardiovasc Genet. 2011;4(1):43–50.PubMedCrossRef
40.
Zurück zum Zitat Baban A, Cicenia M, Magliozzi M, Gnazzo M, Cantarutti N, Silvetti MS, et al. Cardiovascular Involvement in pediatric laminopathies. Report of six patients and literature revision. Front Pediatr. 2020;8(July):1–9. Baban A, Cicenia M, Magliozzi M, Gnazzo M, Cantarutti N, Silvetti MS, et al. Cardiovascular Involvement in pediatric laminopathies. Report of six patients and literature revision. Front Pediatr. 2020;8(July):1–9.
41.
Zurück zum Zitat Campbell MJ, Czosek RJ, Hinton RB, Miller EM. Exon 3 deletion of ryanodine receptor causes left ventricular noncompaction, worsening catecholaminergic polymorphic ventricular tachycardia, and sudden cardiac arrest. Am J Med Genet Part A. 2015;167(9):2197–200.CrossRef Campbell MJ, Czosek RJ, Hinton RB, Miller EM. Exon 3 deletion of ryanodine receptor causes left ventricular noncompaction, worsening catecholaminergic polymorphic ventricular tachycardia, and sudden cardiac arrest. Am J Med Genet Part A. 2015;167(9):2197–200.CrossRef
42.
Zurück zum Zitat Nozaki Y, Kato Y, Uike K, Yamamura K, Kikuchi M, Yasuda M, et al. Co-phenotype of left ventricular non-compaction cardiomyopathy and atypical catecholaminergic polymorphic ventricular tachycardia in association with R169q, a ryanodine receptor type 2 missense mutation. Circ J. 2020;84(2):226–34.PubMedCrossRef Nozaki Y, Kato Y, Uike K, Yamamura K, Kikuchi M, Yasuda M, et al. Co-phenotype of left ventricular non-compaction cardiomyopathy and atypical catecholaminergic polymorphic ventricular tachycardia in association with R169q, a ryanodine receptor type 2 missense mutation. Circ J. 2020;84(2):226–34.PubMedCrossRef
43.
Zurück zum Zitat Ohno S, Omura M, Kawamura M, Kimura H, Itoh H, Makiyama T, et al. Exon 3 deletion of RYR2 encoding cardiac ryanodine receptor is associated with left ventricular non-compaction. Europace. 2014;16(11):1646–54.PubMedCrossRef Ohno S, Omura M, Kawamura M, Kimura H, Itoh H, Makiyama T, et al. Exon 3 deletion of RYR2 encoding cardiac ryanodine receptor is associated with left ventricular non-compaction. Europace. 2014;16(11):1646–54.PubMedCrossRef
45.
Zurück zum Zitat Milano A, Vermeer AMC, Lodder EM, Barc J, Verkerk AO, Postma AV, et al. HCN4 mutations in multiple families with bradycardia and left ventricular noncompaction cardiomyopathy. J Am Coll Cardiol. 2014;64(8):745–56.PubMedCrossRef Milano A, Vermeer AMC, Lodder EM, Barc J, Verkerk AO, Postma AV, et al. HCN4 mutations in multiple families with bradycardia and left ventricular noncompaction cardiomyopathy. J Am Coll Cardiol. 2014;64(8):745–56.PubMedCrossRef
46.
Zurück zum Zitat Schweizer PA, Schröter J, Greiner S, Haas J, Yampolsky P, Mereles D, et al. The symptom complex of familial sinus node dysfunction and myocardial noncompaction is associated with mutations in the HCN4 channel. J Am Coll Cardiol. 2014;64(8):757–67.PubMedCrossRef Schweizer PA, Schröter J, Greiner S, Haas J, Yampolsky P, Mereles D, et al. The symptom complex of familial sinus node dysfunction and myocardial noncompaction is associated with mutations in the HCN4 channel. J Am Coll Cardiol. 2014;64(8):757–67.PubMedCrossRef
47.
Zurück zum Zitat Klaassen S, Probst S, Oechslin E, Gerull B, Krings G, Schuler P, et al. Mutations in sarcomere protein genes in left ventricular noncompaction. Circulation. 2008;117(22):2893–901.PubMedCrossRef Klaassen S, Probst S, Oechslin E, Gerull B, Krings G, Schuler P, et al. Mutations in sarcomere protein genes in left ventricular noncompaction. Circulation. 2008;117(22):2893–901.PubMedCrossRef
48.
Zurück zum Zitat Hoedemaekers YM, Caliskan K, Michels M, Frohn-Mulder I, Van Der Smagt JJ, Phefferkorn JE, et al. The importance of genetic counseling, DNA diagnostics, and cardiologic family screening in left ventricular noncompaction cardiomyopathy. Circ Cardiovasc Genet. 2010;3(3):232–9.PubMedCrossRef Hoedemaekers YM, Caliskan K, Michels M, Frohn-Mulder I, Van Der Smagt JJ, Phefferkorn JE, et al. The importance of genetic counseling, DNA diagnostics, and cardiologic family screening in left ventricular noncompaction cardiomyopathy. Circ Cardiovasc Genet. 2010;3(3):232–9.PubMedCrossRef
49.
Zurück zum Zitat Frustaci A, De Luca A, Guida V, Biagini T, Mazza T, Gaudio C, Letizia C, Russo MA, Galea N, Chimenti C. Novel α-actin gene mutation p.(Ala21Val) causing familial hypertrophic cardiomyopathy, myocardial noncompaction, and transmural crypts. Clinical-Pathologic Correlation. J Am Heart Assoc. 2018;7(4):e008068. Frustaci A, De Luca A, Guida V, Biagini T, Mazza T, Gaudio C, Letizia C, Russo MA, Galea N, Chimenti C. Novel α-actin gene mutation p.(Ala21Val) causing familial hypertrophic cardiomyopathy, myocardial noncompaction, and transmural crypts. Clinical-Pathologic Correlation. J Am Heart Assoc. 2018;7(4):e008068.
50.
Zurück zum Zitat Rigaud C, Lebre AS, Touraine R, Beaupain B, Ottolenghi C, Chabli A, et al. Natural history of Barth syndrome: a national cohort study of 22 patients. Orphanet J Rare Dis. 2013;8(1):9–18.CrossRef Rigaud C, Lebre AS, Touraine R, Beaupain B, Ottolenghi C, Chabli A, et al. Natural history of Barth syndrome: a national cohort study of 22 patients. Orphanet J Rare Dis. 2013;8(1):9–18.CrossRef
52.
Zurück zum Zitat Shan L, Makita N, Xing Y, Watanabe S, Futatani T, Ye F, et al. SCN5A variants in Japanese patients with left ventricular noncompaction and arrhythmia. Mol Genet Metab. 2008;93(4):468–74.PubMedCrossRef Shan L, Makita N, Xing Y, Watanabe S, Futatani T, Ye F, et al. SCN5A variants in Japanese patients with left ventricular noncompaction and arrhythmia. Mol Genet Metab. 2008;93(4):468–74.PubMedCrossRef
53.
Zurück zum Zitat Hermida-Prieto M, Monserrat L, Castro-Beiras A, Laredo R, Soler R, Peteiro J, et al. Familial dilated cardiomyopathy and isolated left ventricular noncompaction associated with lamin A/C gene mutations. Am J Cardiol. 2004;94(1):50–4.PubMedCrossRef Hermida-Prieto M, Monserrat L, Castro-Beiras A, Laredo R, Soler R, Peteiro J, et al. Familial dilated cardiomyopathy and isolated left ventricular noncompaction associated with lamin A/C gene mutations. Am J Cardiol. 2004;94(1):50–4.PubMedCrossRef
55.
Zurück zum Zitat Arbustini E, Favalli V, Narula N, Serio A, Grasso M. Left ventricular noncompaction: a distinct genetic cardiomyopathy? J Am Coll Cardiol. 2016;68(9):949–66.PubMedCrossRef Arbustini E, Favalli V, Narula N, Serio A, Grasso M. Left ventricular noncompaction: a distinct genetic cardiomyopathy? J Am Coll Cardiol. 2016;68(9):949–66.PubMedCrossRef
56.
Zurück zum Zitat Oechslin E, Jenni R. Left ventricular noncompaction: from physiologic remodeling to noncompaction cardiomyopathy ∗. J Am Coll Cardiol. 2018;71(7):723–6.PubMedCrossRef Oechslin E, Jenni R. Left ventricular noncompaction: from physiologic remodeling to noncompaction cardiomyopathy ∗. J Am Coll Cardiol. 2018;71(7):723–6.PubMedCrossRef
57.
Zurück zum Zitat Gati S, Rajani R, Carr-White GS, Chambers JB. Adult left ventricular noncompaction: reappraisal of current diagnostic imaging modalities. JACC Cardiovasc Imaging. 2014;7(12):1266–75.PubMedCrossRef Gati S, Rajani R, Carr-White GS, Chambers JB. Adult left ventricular noncompaction: reappraisal of current diagnostic imaging modalities. JACC Cardiovasc Imaging. 2014;7(12):1266–75.PubMedCrossRef
58.•
Zurück zum Zitat Finocchiaro G, Merlo M, Sheikh N, De Angelis G, Papadakis M, Olivotto I, Rapezzi C, Carr-White G, Sharma S, Mestroni L, Sinagra G. The electrocardiogram in the diagnosis and management of patients with dilated cardiomyopathy. Eur J Heart Fail. 2020;22(7):1097–107. This paper emphasizes the importance of the ECG and the role of systematic approach in its interpretation in patients with cardiomyopathies. Finocchiaro G, Merlo M, Sheikh N, De Angelis G, Papadakis M, Olivotto I, Rapezzi C, Carr-White G, Sharma S, Mestroni L, Sinagra G. The electrocardiogram in the diagnosis and management of patients with dilated cardiomyopathy. Eur J Heart Fail. 2020;22(7):1097–107. This paper emphasizes the importance of the ECG and the role of systematic approach in its interpretation in patients with cardiomyopathies.
59.
Zurück zum Zitat Stähli BE, Gebhard C, Biaggi P, Klaassen S, Valsangiacomo Buechel E, Attenhofer Jost CH, et al. Left ventricular non-compaction: prevalence in congenital heart disease. Int J Cardiol. 2013;167(6):2477–81.PubMedCrossRef Stähli BE, Gebhard C, Biaggi P, Klaassen S, Valsangiacomo Buechel E, Attenhofer Jost CH, et al. Left ventricular non-compaction: prevalence in congenital heart disease. Int J Cardiol. 2013;167(6):2477–81.PubMedCrossRef
60.
Zurück zum Zitat Kumor M, Lipczyńska M, Biernacka EK, Klisiewicz A, Wójcik A, Konka M, et al. Cardiac arrest and ventricular arrhythmia in adults with Ebstein anomaly and left ventricular non-compaction. J Cardiol. 2018;71(5):484–7.PubMedCrossRef Kumor M, Lipczyńska M, Biernacka EK, Klisiewicz A, Wójcik A, Konka M, et al. Cardiac arrest and ventricular arrhythmia in adults with Ebstein anomaly and left ventricular non-compaction. J Cardiol. 2018;71(5):484–7.PubMedCrossRef
61.
Zurück zum Zitat Pignatelli RH, Texter KM, Denfield SW, Grenier MA, Altman CA, Ayres NA, et al. LV noncompaction in ebstein’s anomaly in infants and outcomes. JACC Cardiovasc Imaging. 2014;7(2):207–9.PubMedCrossRef Pignatelli RH, Texter KM, Denfield SW, Grenier MA, Altman CA, Ayres NA, et al. LV noncompaction in ebstein’s anomaly in infants and outcomes. JACC Cardiovasc Imaging. 2014;7(2):207–9.PubMedCrossRef
62.
Zurück zum Zitat Hirono K, Hata Y, Miyao N, Okabe M, Takarada S, Nakaoka H, et al. Left ventricular noncompaction and congenital heart disease increases the risk of congestive heart failure. J Clin Med. 2020;9(3):785.PubMedCentralCrossRef Hirono K, Hata Y, Miyao N, Okabe M, Takarada S, Nakaoka H, et al. Left ventricular noncompaction and congenital heart disease increases the risk of congestive heart failure. J Clin Med. 2020;9(3):785.PubMedCentralCrossRef
63.
Zurück zum Zitat Finsterer J, Stöllberger C, Blazek G. Neuromuscular implications in left ventricular hypertrabeculation/noncompaction. Int J Cardiol. 2006;110(3):288–300.PubMedCrossRef Finsterer J, Stöllberger C, Blazek G. Neuromuscular implications in left ventricular hypertrabeculation/noncompaction. Int J Cardiol. 2006;110(3):288–300.PubMedCrossRef
64.
Zurück zum Zitat Statile CJ, Taylor MD, Mazur W, Cripe LH, King E, Pratt J, et al. Left ventricular noncompaction in Duchenne muscular dystrophy. J Cardiovasc Magn Reson. 2013;15(1):1.CrossRef Statile CJ, Taylor MD, Mazur W, Cripe LH, King E, Pratt J, et al. Left ventricular noncompaction in Duchenne muscular dystrophy. J Cardiovasc Magn Reson. 2013;15(1):1.CrossRef
65.
Zurück zum Zitat Stöllberger C, Winkler-Dworak M, Blazek G, Finsterer J. Association of electrocardiographic abnormalities with cardiac findings and neuromuscular disorders in left ventricular hypertrabeculation/non-compaction. Cardiology. 2007;107(4):374–9.PubMedCrossRef Stöllberger C, Winkler-Dworak M, Blazek G, Finsterer J. Association of electrocardiographic abnormalities with cardiac findings and neuromuscular disorders in left ventricular hypertrabeculation/non-compaction. Cardiology. 2007;107(4):374–9.PubMedCrossRef
66.
Zurück zum Zitat Stöllberger C, Gerger D, Jirak P, Wegner C, Finsterer J. Evolution of electrocardiographic abnormalities in association with neuromuscular disorders and survival in left ventricular hypertrabeculation/noncompaction. Ann Noninvasive Electrocardiol. 2014;19(6):567–73.PubMedPubMedCentralCrossRef Stöllberger C, Gerger D, Jirak P, Wegner C, Finsterer J. Evolution of electrocardiographic abnormalities in association with neuromuscular disorders and survival in left ventricular hypertrabeculation/noncompaction. Ann Noninvasive Electrocardiol. 2014;19(6):567–73.PubMedPubMedCentralCrossRef
67.
Zurück zum Zitat Stöllberger C, Finsterer J. How to manage left ventricular hypertrabeculation/noncompaction in Fabry’s disease? Cardiology. 2011;120(2):95–6.PubMedCrossRef Stöllberger C, Finsterer J. How to manage left ventricular hypertrabeculation/noncompaction in Fabry’s disease? Cardiology. 2011;120(2):95–6.PubMedCrossRef
69.
Zurück zum Zitat Clarke SLN, Bowron A, Gonzalez IL, Groves SJ, Newbury-Ecob R, Clayton N, et al. Barth syndrome. Orphanet J Rare Dis. 2013;8(1):1–17.CrossRef Clarke SLN, Bowron A, Gonzalez IL, Groves SJ, Newbury-Ecob R, Clayton N, et al. Barth syndrome. Orphanet J Rare Dis. 2013;8(1):1–17.CrossRef
70.
Zurück zum Zitat Ferreira C, Pierre G, Thompson R, Vernon H, Adam MP, Everman DB, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A (editors). Barth syndrome. In: GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993. 2014 Oct 9 [updated 2020 Jul 9]. Ferreira C, Pierre G, Thompson R, Vernon H, Adam MP, Everman DB, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A (editors). Barth syndrome. In: GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993. 2014 Oct 9 [updated 2020 Jul 9].
71.
Zurück zum Zitat Spencer CT, Bryant RM, Day J, Gonzalez IL, Colan SD, Thompson WR, Berthy J, Redfearn SP, Byrne BJ. Cardiac and clinical phenotype in Barth syndrome. Pediatrics. 2006;118(2):e337–46. Spencer CT, Bryant RM, Day J, Gonzalez IL, Colan SD, Thompson WR, Berthy J, Redfearn SP, Byrne BJ. Cardiac and clinical phenotype in Barth syndrome. Pediatrics. 2006;118(2):e337–46.
72.
Zurück zum Zitat Gati S, Sharma S, Pennell D. The role of cardiovascular magnetic resonance imaging in the assessment of highly trained athletes. JACC Cardiovasc Imaging. 2018;11(2 Pt 1):247–59.PubMedCrossRef Gati S, Sharma S, Pennell D. The role of cardiovascular magnetic resonance imaging in the assessment of highly trained athletes. JACC Cardiovasc Imaging. 2018;11(2 Pt 1):247–59.PubMedCrossRef
73.
Zurück zum Zitat Gati S, Rajani R, Carr-White GS, Chambers JB. Adult left ventricular noncompaction: reappraisal of current diagnostic imaging modalities. JACC Cardiovasc Imaging. 2014;7(12):1266–75.PubMedCrossRef Gati S, Rajani R, Carr-White GS, Chambers JB. Adult left ventricular noncompaction: reappraisal of current diagnostic imaging modalities. JACC Cardiovasc Imaging. 2014;7(12):1266–75.PubMedCrossRef
74.
Zurück zum Zitat Steffel J, Hürlimann D, Namdar M, Despotovic D, Kobza R, Wolber T, et al. Long-term follow-up of patients with isolated left ventricular noncompaction: role of electrocardiography in predicting poor outcome. Circ J. 2011;75(7):1728–34.PubMedCrossRef Steffel J, Hürlimann D, Namdar M, Despotovic D, Kobza R, Wolber T, et al. Long-term follow-up of patients with isolated left ventricular noncompaction: role of electrocardiography in predicting poor outcome. Circ J. 2011;75(7):1728–34.PubMedCrossRef
76.
Zurück zum Zitat Weiford BC, Subbarao VD, Mulhern KM. Noncompaction of the ventricular myocardium. Circulation. 2004;109(24):2965–71.PubMedCrossRef Weiford BC, Subbarao VD, Mulhern KM. Noncompaction of the ventricular myocardium. Circulation. 2004;109(24):2965–71.PubMedCrossRef
77.
Zurück zum Zitat Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Vol. 37. Eur Heart J. 2016;2016:2129–2200m.CrossRef Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Vol. 37. Eur Heart J. 2016;2016:2129–2200m.CrossRef
78.
Zurück zum Zitat Zhou H, Lin X, Fang L, Zhu W, Zhao X, Ding H, et al. Prolonged QTc indicates the clinical severity and poor prognosis in patients with isolated left ventricular non-compaction. Int J Cardiovasc Imaging. 2017;33(12):2013–20.PubMedCrossRef Zhou H, Lin X, Fang L, Zhu W, Zhao X, Ding H, et al. Prolonged QTc indicates the clinical severity and poor prognosis in patients with isolated left ventricular non-compaction. Int J Cardiovasc Imaging. 2017;33(12):2013–20.PubMedCrossRef
79.
Zurück zum Zitat Murphy RT, Thaman R, Blanes JG, Ward D, Sevdalis E, Papra E, et al. Natural history and familial characteristics of isolated left ventricular non-compaction. Eur Heart J. 2005;26(2):187–92 (80).PubMedCrossRef Murphy RT, Thaman R, Blanes JG, Ward D, Sevdalis E, Papra E, et al. Natural history and familial characteristics of isolated left ventricular non-compaction. Eur Heart J. 2005;26(2):187–92 (80).PubMedCrossRef
Metadaten
Titel
The Electrocardiogram in the Diagnosis and Management of Patients With Left Ventricular Non-Compaction
verfasst von
Giuseppe D. Sanna
Anna Piga
Guido Parodi
Gianfranco Sinagra
Michael Papadakis
Antonis Pantazis
Sanjay Sharma
Sabiha Gati
Gherardo Finocchiaro
Publikationsdatum
13.10.2022
Verlag
Springer US
Erschienen in
Current Heart Failure Reports / Ausgabe 6/2022
Print ISSN: 1546-9530
Elektronische ISSN: 1546-9549
DOI
https://doi.org/10.1007/s11897-022-00580-z

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