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Klimawandel und Gesundheit: Was Sie in der Hausarztpraxis wissen müssen und tun können

Die Folgen des Klimwandels haben einen direkten Einfluss auf die Primärversorgung in Deutschland: Hitzeschutz insbesondere bei älteren Patienten, die Zunahme von Infektionen und die Verlängerung der Allergiesesaison spielen medizinisch eine bedeutsame Rolle. Aber auch in der Prävention und der Aufklärung der Patienten kommt den Hausärztinnen und -ärzten eine besondere Rolle zu. Direkt aus der Praxis berichtet im Live-Webinar am 13. Mai von 18 bis 19 Uhr unser Experte Dr. med. Robin Maitra.
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Brain Tumor Pathology
Erschienen in: Brain Tumor Pathology 2/2019

11.03.2019 | Review Article

The emerging clinical potential of circulating extracellular vesicles for non-invasive glioma diagnosis and disease monitoring

verfasst von: Susannah Hallal, Saeideh Ebrahimkhani, Brindha Shivalingam, Manuel B. Graeber, Kimberley L. Kaufman, Michael E. Buckland

Erschienen in: Brain Tumor Pathology | Ausgabe 2/2019

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Abstract

Diffuse gliomas (grades II–IV) are amongst the most frequent and devastating primary brain tumours of adults. Currently, patients are monitored by clinical examination and radiographic imaging, which can be challenging to interpret and insensitive to early signs of treatment failure and tumour relapse. While brain biopsy and histologic analysis can evaluate disease progression, serial biopsies are invasive and impractical given the cumulative surgical risk, and may not capture the complete molecular landscape of an evolving tumour. The availability of a minimally invasive ‘liquid biopsy’ that could assess tumour activity and molecular phenotype in situ has the potential to greatly enhance patient care. Circulating extracellular vesicles (EVs) hold significant promise as robust disease-specific biomarkers accessible in the blood of patients with glioblastoma and other diffuse gliomas. EVs are membrane-bound nanoparticles shed from most if not all cells of the body, and carry DNA, RNA, protein, and lipids that reflect the identity and molecular state of their cell-of-origin. EVs can cross the blood–brain barrier and their release is upregulated in neoplasia. In this review, we describe the current knowledge of EV biology, the role of EVs in glioma biology and the current experience and challenges in profiling glioma-EVs from the circulation.
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Metadaten
Titel
The emerging clinical potential of circulating extracellular vesicles for non-invasive glioma diagnosis and disease monitoring
verfasst von
Susannah Hallal
Saeideh Ebrahimkhani
Brindha Shivalingam
Manuel B. Graeber
Kimberley L. Kaufman
Michael E. Buckland
Publikationsdatum
11.03.2019
Verlag
Springer Singapore
Erschienen in
Brain Tumor Pathology / Ausgabe 2/2019
Print ISSN: 1433-7398
Elektronische ISSN: 1861-387X
DOI
https://doi.org/10.1007/s10014-019-00335-0

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