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Social Psychiatry and Psychiatric Epidemiology

Erschienen in:

01.03.2014 | Invited Reviews

The epigenome and postnatal environmental influences in psychotic disorders

verfasst von: Ehsan Pishva, Gunter Kenis, Daniel van den Hove, Klaus-Peter Lesch, Marco P. M. Boks, Jim van Os, Bart P. F. Rutten

Erschienen in: Social Psychiatry and Psychiatric Epidemiology | Ausgabe 3/2014

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Abstract

Objectives

Schizophrenia spectrum disorders and bipolar spectrum disorders are the product of both heritable and non-heritable factors, the impact of which converges at different biological levels. Recent evidence from molecular approaches has provided new insights about how environmental exposures cause persistent alterations in the regulation of gene expression, particularly by so-called epigenetic mechanisms. The aim of this review is to provide an overview of findings of epigenetic studies in psychotic disorders, summarizing findings of human and animal studies on epigenetic alterations due to postnatal environmental exposures associated with psychotic disorders.

Methods

Electronic and manual literature search of MEDLINE, EMBASE and PSYCHINFO, using a range of search terms around epigenetics, DNA methylation, histone modifications, psychoses, schizophrenia, bipolar disorder and environmental risks associated with psychotic disorders as observed in human and experimental animal studies, complemented by review articles and cross-references.

Results

Despite several promising findings of differential epigenetic profiles in individuals with psychotic disorders in the studies published to date, the knowledge of the role of epigenetic processes in psychotic disorder remains very limited, and should be interpreted cautiously given various challenges in this rapidly evolving field of research.

Conclusions

Integration of epigenetic findings into biopsychosocial models of the etiology of psychotic disorders eventually may yield important insights into the biological underpinnings of the onset and course of psychotic disorders.

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Titel: The epigenome and postnatal environmental influences in psychotic disorders
verfasst von: Ehsan Pishva
Gunter Kenis
Daniel van den Hove
Klaus-Peter Lesch
Marco P. M. Boks
Jim van Os
Bart P. F. Rutten
Publikationsdatum: 01.03.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Social Psychiatry and Psychiatric Epidemiology / Ausgabe 3/2014
Print ISSN: 0933-7954
Elektronische ISSN: 1433-9285
DOI: https://doi.org/10.1007/s00127-014-0831-2

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