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Current Cardiovascular Risk Reports
Erschienen in: Current Cardiovascular Risk Reports 2/2011

01.04.2011

The Global Burden of Cardiovascular Disease: The Role of Endothelial Function and Arterial Elasticity in Cardiovascular Disease as Novel and Emerging Biomarkers

verfasst von: Stephen P. Glasser, Tanja Dudenbostel

Erschienen in: Current Cardiovascular Risk Reports | Ausgabe 2/2011

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Abstract

Some consider the measurements of arterial elasticity and flow-mediated dilation to be an indirect “biomarker” of endothelial dysfunction. As such, we describe the various uses of these techniques in the evaluation of the natural history of vascular disease. These measures are potential markers of disease, as abnormalities reflect changes in the integrity of vascular structure but occur prior to the manifestation of symptomatic cardiovascular events. In this review, the natural history of arterial elasticity is discussed, and the effects of aging and inflammation are reviewed. The role that arterial elasticity and flow-mediated dilation have in predicting future cardiovascular disease, and the effects of pharmacologic agents on these measures, is also reviewed.
Literatur
1.
Lee R, Kamm R., Vascular mechanics for the cardiologist. J Am Coll Cardiol, 1994. 23(6): p. 1289–95.PubMedCrossRef
2.
Zimlichman R, Boaz M, Duprez D, et al., The Seven European Sites Study of Arterial Elasticity - Using the Blood Pressure Wave Form Analysis - Reliability, Repeatability and Establishment of Normal Values for Healthy European Population with Comparison to Healthy U.S. Population. American Journal of Hypertension, 2003. 16(No. 5, Part 2): p. P315.
3.
Arnett DK, Glasser SP, McVeigh G, et al., Blood pressure and arterial compliance in young adults: the Minnesota Children’s Blood Pressure Study. Am J Hypertens, 2001. 14(3): p. 200–5.PubMedCrossRef
4.
Bhuiyan AR, Li S, Li H, et al., Distribution and correlates of arterial compliance measures in asymptomatic young adults: the Bogalusa Heart Study. Am J Hypertens, 2005. 18(5 Pt 1): p. 684–91.PubMedCrossRef
5.
Valappil NI, Jacobs DR, Gross MD, et al., Correlates of Arterial Compliance in Young Adults: The CARDIA Study. The Journal of Clinical Hypertension Supplement, 2007. 9(5): p. A10.
6.
Glasser SP, Arnett DK, McVeigh GE, et al., Vascular compliance and cardiovascular disease: a risk factor or a marker? Am J Hypertens, 1997. 10(10 Pt 1): p. 1175–89.PubMedCrossRef
7.
Liao D, Arnett DK, Herman A, et al., Arterial stiffness and the development of hypertension. The ARIC study. Hypertension, 1999. 34(2): p. 201–6.PubMed
8.
Julius S, Nesbitt SD, Egan BM, et al., Feasibility of treating prehypertension with an angiotensin-receptor blocker. N Engl J Med, 2006. 354(16): p. 1685–97.PubMedCrossRef
9.
Glasser, S.P., On Arterial Physiology, Pathophysiology of Vascular Compliance, and Cardiovascular Disease. Heart Disease, 2000. 2: p. 375–379.PubMed
10.
Cohn, J.N., Vascular wall function as a risk marker for cardiovascular disease. J Hypertens Suppl, 1999. 17(5): p. S41–4.PubMed
11.
•• Najjar SS, Scuteri A, Shetty V, et al., Pulse Wave Velocity is an Independent Predictor of the Longitudinal Increase in Systolic Glood Pressure and of Incident Hypertension in the Baltimore Longitudinal Study of Aging. J Am Coll Cardiol, 2008. 51: p. 1377–1383. This article presents evidence that links many biochemical, enzymatic, and cellular alterations, as well as their modulating signals, to accelerated vascular aging and the pathogenesis and progression of arterial diseases.PubMedCrossRef
12.
McVeigh GE, Bratteli CW, Morgan DJ, et al., Age-related abnormalities in arterial compliance identified by pressure pulse contour analysis: aging and arterial compliance. Hypertension, 1999. 33(6): p. 1392–8.PubMed
13.
Gilani M, Alinder C, Kaiser D, et al., Differences in Large and Small Artery Response to Acute Inhibition of Nitric Oxide Synthase in Human Subjects. Am J Hypertens, 2000. 13(4 (part 2) Abstract No. B003).
14.
McVeigh GE, Allen PB, Morgan DR, et al., Nitric oxide modulation of blood vessel tone identified by arterial waveform analysis. Clin Sci (Lond), 2001. 100(4): p. 387–93.CrossRef
15.
Weinberger MH, Fineberg NS, Weinberg M, et al., The Relationships Between Age, Gender and Blood Pressure and Vascular Compliance and Resistance in Normal and Hypertensive Humans. American Journal of Hypertension, 2001. 14(4 Part 2 Orals No. O16).
16.
Takeuchi K, Zhang B, Ideishi M, et al., Influence of age and hypertension on the association between small artery compliance and coronary artery disease. Am J Hypertens, 2004. 17(12 Pt 1): p. 1188–91.PubMedCrossRef
17.
Duprez DA, Somasundaram PE, Sigurdsson G, et al., Relationship between C-reactive protein and arterial stiffness in an asymptomatic population. J Human Hypet, 2005. 19: p. 515–519.CrossRef
18.
• Saijo Y, Utsugi M, Yoshioka E, et al., The relationship of gamma-glutamyltransferase to C-reactive protein and arterial stiffness. Nutr Metab Cardiovasc Dis, 2008. 18(3): p. 211–9. This article discusses the role of inflammatory markers and vascular disease.PubMedCrossRef
19.
Mahmud A, Feely J, Arterial stiffness is related to systemic inflammation in essential hypertension. Hypertension, 2005. 46(5): p. 1118–22.PubMedCrossRef
20.
Kim JS, Kang TS, Kim JB, et al., Significant association of C-reactive protein with arterial stiffness in treated non-diabetic hypertensive patients. Atherosclerosis, 2007. 192(2): p. 401–6.PubMedCrossRef
21.
Booth AD, Wallace S, McEniery CM, et al., Inflammation and Arterial Stiffness in systemic Vasculitis A model of Vascular Inflammation. Arthritis & Rheumatism, 2004. 50: p. 581–588.CrossRef
22.
Vlachopoulos C, Dima I, Aznaouridis K, et al., Acute systemic inflammation increases arterial stiffness and decreases wave reflections in healthy individuals. Circulation, 2005. 112(14): p. 2193–200.PubMedCrossRef
23.
•• Tuttolomondo A, Di Raimondo D, Pecoraro R., et al, Immune-inflammatory markers and arterial stiffness indexes in subjects with acute ischemic stroke. Atherosclerosis, 2010. 213(1): p. 311–318. This is one of the first studies evaluating the relationship between arterial elasticity and immune inflammatory markers in acute cerebrovascular disease.PubMedCrossRef
24.
•• Mitchell GF, Hwang S, Vasan RS, et al., Arterial stiffness and cardiovascular events: the Framingham Heart Study. Circulation, 2010. 121(4): p. 505–11. This analysis of 2232 participants from the Framingham Heart Study focuses on aortic PVW as a potential novel biomarker of cardiovascular risk.PubMedCrossRef
25.
Laurent S, Boutouyrie P, Asmar R, et al., Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension, 2001. 37(5): p. 1236–41.PubMed
26.
Williams B, O’Rourke M, The Conduit Artery Functional Endpoint (CAFE) study in ASCOT. J Hum Hypertens, 2001. 15 Suppl 1: p. S69–73.PubMed
27.
•• Duprez DA, Jacobs Jr DR, Lutseyl P, et al., Small Artery but not Large Artery Elasticity Coronary Heart Disease Events Beyond Coronary Calcium Score and Carotid Intima Media Thickness in an Asymptomatic Population, in ACC International Meeting. 2009. The potential value of techniques that differentiate smaller from larger vessel elasticity is suggested in this study.
28.
Duprez DA, Jacobs Jr DR, Luseyl P, et al., Large and Small Artery elasticity, but not Coronary Calcium Score and Carotid Intima Media Thickness, Predict Incident Congestive Heart Failure Events in an Asymptomatic Population: Results of the Multi-Ethnic Study of Atherosclerosis, in Acc International Meeting. 2009.
29.
Bhuiyan AR, Srinivasan SR, Chen W, et al., Correlates of vascular structure and function measures in asymptomatic young adults: the Bogalusa Heart Study. Atherosclerosis, 2006. 189(1): p. 1–7.PubMedCrossRef
30.
Cohn JN, Duprez DA, Grandits GA, Arterial elasticity as part of a comprehensive assessment of cardiovascular risk and drug treatment. Hypertension, 2005. 46(1): p. 217–20.PubMedCrossRef
31.
•• Weiss SA, Blumenthal RS, Sharrett AR, et al., Exercise blood pressure and future cardiovascular death in asymptomatic individuals. Circulation, 2010. 121(19): p. 2109–16. Vascular elasticity is a determinate of the BP response to exercise, and its ability to predict future CVD events in asymptomatic subjects is suggested by this study.PubMedCrossRef
32.
Duprez D, DeBuyzere M, Van Den Noortgate N, et al., Relationship Between Periventricular or Deep White Matter Lesions and Arterial Elasticity Indices in Very Old People. Age and Ageing, 2001. 30: p. 325–330.PubMedCrossRef
33.
Duprez D, DeBuyzere ML, DeBruyne L, et al., Small and Large Artery Elasticity Indices in Peripheral Arterial Occlusive Disease (PAOD). Vascular Medicine, 2001. 6: p. 211–214.PubMedCrossRef
34.
Beltran A, McVeigh G, Morgan D, et al., Arterial compliance abnormalities in isolated systolic hypertension. Am J Hypertens, 2001. 14(10): p. 1007–11.PubMedCrossRef
35.
Grey E, Bratteli C, Glasser SP, et al., Reduced small artery but not large artery elasticity is an independent risk marker for cardiovascular events. Am J Hypertens, 2003. 16(4): p. 265–9.PubMedCrossRef
36.
Glasser SP, Arnett DK, McVeigh GE, et al., The importance of arterial compliance in cardiovascular drug therapy. J Clin Pharmacol, 1998. 38(3): p. 202–12.PubMed
37.
• Cohn JN, Goldman JM, Establishing a new option for target-organ protection: rationale for ARB plus ACE inhibitor combination therapy. Am J Hypertens, 2008. 21(3): p. 248–56. The fact that different drugs impact arterial elasticity differentially is emphasized in this study.PubMedCrossRef
38.
Bratteli CW, Alinder CM, Cohn JN, Contrasting Arterial Compliance Effects of Enalapril and amlodipine in Normotensive Elderly Subjects. American Journal of Hypertension, 1999. 12(4 part 2 Abstract No B015).
39.
Resnick LM, Lester MH, and Chesney CF, Differential Effects of Antihypertensive Drug Therapy on Arterial Compliance, in 15th Scientific Meeting of the American Society of Hypertension. 2000, American Journal of Hypertension. p. 20A.
40.
Corretti MC, Anderson TJ, Benjamin EJ, et al., Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol, 2002. 39(2): p. 257–65.PubMedCrossRef
41.
Celermajer DS, Sorensen KE, Gooch VM, et al., Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet, 1992. 340(8828): p. 1111–5.PubMedCrossRef
42.
Celermajer DS, Adams MR, Clarkson P, et al., Passive smoking and impaired endothelium-dependent arterial dilatation in healthy young adults. N Engl J Med, 1996. 334(3): p. 150–4.PubMedCrossRef
43.
Gokce N, Holbrook M, Duffy SJ, et al., Effects of race and hypertension on flow-mediated and nitroglycerin-mediated dilation of the brachial artery. Hypertension, 2001. 38(6): p. 1349–54.PubMedCrossRef
44.
Koh KK, Han SH, Chung WJ, et al., Comparison of effects of losartan, irbesartan, and candesartan on flow-mediated brachial artery dilation and on inflammatory and thrombolytic markers in patients with systemic hypertension. Am J Cardiol, 2004. 93(11): p. 1432–5, A10.
45.
Rajagopalan SR, Kariisa M, Dellegrottaglie S, et al., Angiotensin Receptor Blockade Imporves Vascular Compliance in Healthy Normotensive elderly Individuals: Results from a Randomized Double-Blind Placebo-Controlled Trial. The Journal of Clinical Hypertension, 2006. 8(11): p. 783–790.PubMedCrossRef
46.
Yilmaz MI, Carrero JJ, Martin-Ventura JL, et al., Combined therapy with renin-angiotensin system and calcium channel blockers in type 2 diabetic hypertensive patients with proteinuria: effects on soluble TWEAK, PTX3, and flow-mediated dilation. Clin J Am Soc Nephrol, 2010. 5(7): p. 1174–81.PubMedCrossRef
47.
Yilmaz MI, Axelsson J, Sonmez A, et al., Effect of renin angiotensin system blockade on pentraxin 3 levels in type-2 diabetic patients with proteinuria. Clin J Am Soc Nephrol, 2009. 4(3): p. 535–41.PubMedCrossRef
48.
Pasini AF, Garbin U, Stranieri, et al., Nebivolol treatment reduces serum levels of asymmetric dimethylarginine and improves endothelial dysfunction in essential hypertensive patients. Am J Hypertens, 2008. 21(11): p. 1251–7.PubMedCrossRef
49.
Merchant N, Searles CD, Pandian A, et al., Nebivolol in high-risk, obese African Americans with stage 1 hypertension: effects on blood pressure, vascular compliance, and endothelial function. J Clin Hypertens (Greenwich), 2009. 11(12): p. 720–5.CrossRef
50.
Ghiadoni L, Magagna A, Versari D, et al., Different effect of antihypertensive drugs on conduit artery endothelial function. Hypertension, 2003. 41(6): p. 1281–6.PubMedCrossRef
51.
Souza-Barbosa L, Ferreira-Melo SE, Ubaid-Girioli S, et al., Endothelial Vascular Function in Hypertensive Patients After Renin—Angiotensin System Blockade. The Journal of Clinical Hypertension. 2006;8: 803–811.PubMedCrossRef
52.
Nishizaka MK, Zaman MA, Green SA, et al., Impaired endothelium-dependent flow-mediated vasodilation in hypertensive subjects with hyperaldosteronism. Circulation, 2004. 109(23): p. 2857–61.PubMedCrossRef
53.
Singh TP, Groehn H, Kazmers A, Vascular function and carotid intimal-medial thickness in children with insulin-dependent diabetes mellitus. J Am Coll Cardiol, 2003. 41(4): p. 661–5.PubMedCrossRef
54.
Suwaidi JA, Hamasaki S, Higano ST, et al., Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation, 2000. 101(9): p. 948–54.PubMed
Metadaten
Titel
The Global Burden of Cardiovascular Disease: The Role of Endothelial Function and Arterial Elasticity in Cardiovascular Disease as Novel and Emerging Biomarkers
verfasst von
Stephen P. Glasser
Tanja Dudenbostel
Publikationsdatum
01.04.2011
Verlag
Current Science Inc.
Erschienen in
Current Cardiovascular Risk Reports / Ausgabe 2/2011
Print ISSN: 1932-9520
Elektronische ISSN: 1932-9563
DOI
https://doi.org/10.1007/s12170-010-0151-3

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