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Breast Cancer Research and Treatment

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01.07.2009 | Review

The hedgehog pathway as a therapeutic target for treatment of breast cancer

verfasst von: M. F. Barginear, M. Leung, D. R. Budman

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 2/2009

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Abstract

The Hedgehog (Hh) signaling pathway plays a key role in a variety of processes, such as embryogenesis and maintenance of adult tissue homeostasis. It is also becoming increasingly clear that this pathway can have a crucial role in tumorigenesis. Most recently, the Hh signaling pathway has been implicated in the development and maintenance of breast cancer. Here we review Hh signaling, advances in small molecule and antibody-based inhibitors targeting the Hh pathway, and dysregulation of the Hh signaling pathway in breast cancer.

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Titel: The hedgehog pathway as a therapeutic target for treatment of breast cancer
verfasst von: M. F. Barginear
M. Leung
D. R. Budman
Publikationsdatum: 01.07.2009
Verlag: Springer US
Erschienen in: Breast Cancer Research and Treatment / Ausgabe 2/2009
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-009-0423-0

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The hedgehog pathway as a therapeutic target for treatment of breast cancer

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