Introduction
Materials and methods
Results
Effect of UDS on the management offered
Treatment | |||||
---|---|---|---|---|---|
UDS diagnosis | DO surgery (plus bladder relaxants) | USI surgery (plus bladder relaxants) | Bladder relaxants only | No treatment | Total |
DO + USI | 3 (3) | 27 (11) | 29 | 23 | 82 |
DO | 19 (5) | 6 (3) | 119 | 57 | 201 |
USI | 2 (0) | 18 (6) | 16 | 25 | 61 |
Normal UDS | 6 (1) | 6 (1) | 41 | 70 | 123 |
Total | 30 | 57 | 205 | 175 | 467a
|
Treatment | |||
---|---|---|---|
Diagnosis effect | DO surgery OR (95%CI) | USI surgery OR (95%CI) | Bladder relaxants OR (95%CI) |
DO vs normal UDS | 2.6 (1.2, 5.4) | 1.0 (0.3, 2.7) | 3.3 (2.4, 4.7) |
DO + USI vs normal UDS | 0.8 (0.2, 2.8) | 14.9 (6.6, 33.8) | 2.0 (1.2, 3.2) |
USI vs normal UDS | 1.0 (0.3, 3.2) | 8.2 (3.5, 19.3) | 1.1 (0.7, 1.9) |
Medium-term response in the entire cohort
Mean (SD), n
| Change from baseline: mean, 95%CI, p value | |
---|---|---|
Baseline | 9.3 (2.7), 637 | |
7 months | 7.3 (3.3), 469 | −1.9 (−2.2, −1.6), < 0.0001 |
20 months | 7.0 (3.5), 460 | −2.2 (−2.5, −1.9), < 0.0001 |
Medium-term responses by UDS diagnoses
UDS diagnosis | ||||
---|---|---|---|---|
DO + USI | DO | USI | Nothing | |
Baseline mean (SD), n
| 9.8 (2.5) | 9.8 (2.7) | 8.9 (2.7) | 8.2 (2.3) |
7 months mean (SD), n
| 6.8 (3.5), 81 | 8.1 (3.4), 207 | 7.1 (3.3), 57 | 6.5 (2.8), 124 |
20 months mean (SD), n
| 6.6 (3.6), 82 | 7.7 (3.8), 199 | 6.2 (3.3), 55 | 6.5 (3.1), 123 |
Effect of receiving a medical or surgical treatment concordant with a UDS diagnosis
UDS diagnosis | Concordant medical or surgical treatment = no (%) | Concordant medical or surgical treatment = yes (%) | OR (95%CI) |
---|---|---|---|
DO + USI | 8/25 (32) | 39/55 (71) | 5.2 (1.9, 14.4) |
DO | 36/79 (46) | 63/118 (53) | 1.4 (0.8, 2.4) |
USI | 24/41 (59) | 10/14 (71) | 1.8 (0.5, 6.6) |
Normal UDS | 1/7 (14) | 56/109 (51) | 6.3 (0.7, 54.4) |
Total | 69/152 (45) | 168/296 (57) |