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Neuropsychology Review

Erschienen in:

01.03.2014 | Review

The Implications of Brain Connectivity in the Neuropsychology of Autism

verfasst von: Jose O. Maximo, Elyse J. Cadena, Rajesh K. Kana

Erschienen in: Neuropsychology Review | Ausgabe 1/2014

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Abstract

Autism is a neurodevelopmental disorder that has been associated with atypical brain functioning. Functional connectivity MRI (fcMRI) studies examining neural networks in autism have seen an exponential rise over the last decade. Such investigations have led to the characterization of autism as a distributed neural systems disorder. Studies have found widespread cortical underconnectivity, local overconnectivity, and mixed results suggesting disrupted brain connectivity as a potential neural signature of autism. In this review, we summarize the findings of previous fcMRI studies in autism with a detailed examination of their methodology, in order to better understand its potential and to delineate the pitfalls. We also address how a multimodal neuroimaging approach (incorporating different measures of brain connectivity) may help characterize the complex neurobiology of autism at a global level. Finally, we also address the potential of neuroimaging-based markers in assisting neuropsychological assessment of autism. The quest for a neural marker for autism is still ongoing, yet new findings suggest that aberrant brain connectivity may be a promising candidate.

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Titel: The Implications of Brain Connectivity in the Neuropsychology of Autism
verfasst von: Jose O. Maximo
Elyse J. Cadena
Rajesh K. Kana
Publikationsdatum: 01.03.2014
Verlag: Springer US
Erschienen in: Neuropsychology Review / Ausgabe 1/2014
Print ISSN: 1040-7308
Elektronische ISSN: 1573-6660
DOI: https://doi.org/10.1007/s11065-014-9250-0

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