When undertaking image comparison of the hand between accused and perpetrator, it is not unusual for scars to be identified on the back of the hand. To investigate the occurrence of scarring in a discreet sample, a database of 238 individuals was examined, and the dorsum of the right and left hands was gridded for each individual. The position, size and type of scar were recorded within each grid. It was found that, in general, males exhibited a higher incidence of scarring than females. However, males were more likely to show scarring on their left hand whereas females were more likely to exhibit scarring on their right hand. Contrary to the literature, scarring was not most prevalent along the borders of the hand but occurred more frequently in association with the index and middle finger corridor regions. Surgical scars were rare as were large scars whereas linear scars smaller than 6 mm were the most frequently identified. Close to half of the sample did not exhibit scarring on one hand. The importance of understanding the pattern of scarring on the back of the hand is discussed in the light of forensic image comparison analysis.
Introduction
The human hand is an effective and efficient manipulator of the environment with which it interacts [1]. Next to the face, the hand is the most familiar region of the body as it is frequently on display, rarely covered and is a source of familiarity through interpersonal communication and physical interaction [2]. Within the biometrics and forensic science communities, the hand has been widely accepted for its role in the verification of identity [3], particularly in relation to variation recognised in palmar and digital epidermal prints [4, 5]. However, the dorsum of the hand has also proved to be of value for such purposes, and features that have been investigated include variation in knuckle skin crease patterns, pigmentation distribution and superficial vein patterns [6‐9].
The basic function of this appendage is to interact with the immediate environment, and, as a result, it is vulnerable to physical insults that may alter or modify its appearance [10]. Over 20 % of patients attending Accident and Emergency (A&E) departments in the UK each year have a hand injury, which equates to over 1.36 million attendances each year, of which 5 % will require surgery [11]. Isolated hand and wrist injuries accounted for 6.6 % of all new A&E admissions in Northern Ireland [12] with a consensus that probably between 10 % and 20 % of all admissions are related to hand injuries [13, 14]. This general incidence rate appears to hold true in other countries with the research by Rosberg and Dahlin [15] in Malmo, Sweden, concurring that 12 % of A&E admissions relate to hand injuries.
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Rosberg and Dahlin [15] and Hill et al. [12] suggested that the demographic most at risk from hand injuries are young males between the ages of 11 and 25 years. Rosberg and Dahlin [15] also reported that injuries occur more frequently to the border regions of the hand and specifically to the thumb or small finger. It is reported that around 75 % of the population is right-handed and 15 % left-handed with the ability to be truly ambidextrous being relatively rare [16, 17]. The dominance of the hand is reported to have a significant influence of the incidence of injury with the dominant hand more likely to show injury than the non-dominant hand. Hill et al. [12] agreed with this proposal but found that the non-dominant hand was at increased risk of injury when a knife was involved with a ratio of 1:3.4 for dominant to non-dominant hands. Other common causes of injury (broken glass, opening a tin, fall on hand, hand caught between objects, hand through window/door, etc.) showed a higher ratio of injuries to the dominant over the non-dominant hand. Sorock et al. [18] found that right-handed people injured their left hand in 55.4 % of cases and left-handed people injured their right hand in 57.7 % of cases.
It is generally held that scars resulting from medical intervention are of lesser value for verification purposes than scars that originate from an accidental aetiology as, for the former, there are common factors whereas accidental scars offer more random characteristics such as location, size, healing pattern, etc. [19‐21]. Whilst most surgical scars can be readily differentiated from accidental scars mainly due to their appearance and position in relation to Langer’s lines [22], in some instances, especially if the scars are small, it may be difficult to diagnose aetiology with accuracy. However, in reality, the incidence of surgical scars is considered to be very small compared with accidental scars, the majority of which will never result in a visit to A&E, let alone an operating theatre, and therefore, for the purposes of verification of identity, they may in fact be misrepresented in terms of their discriminatory value for the purposes of identification [19].
Within the biometrics and forensic science communities, the hand is viewed as being sufficiently individuating to fulfil the requirements for verification of identity but is considered to be of lesser value in the establishment of identity [23]. For the purposes of verification, two data sets are required that can be compared for features of similarity and difference. The strength of that relationship can then be expressed on the basis of likelihood ratios that the two sets either arise from the same individual or from a different individual [24‐26]. Guidelines for the forensic comparison of images within the UK were published by the National Policing Improvement Agency [27] on behalf of the Association of Chief Police Officers, and the document laid out several important considerations in relation to image comparison for the purpose of verification of identity in a legal setting. Although aimed at comparison of the face, this document applies equally well to comparison of other regions of the body including the hand. Image comparison depends strongly on the quality of the images, and the NPIA document stated that identification through comparison of images does not have ‘evidential value unless it demonstrates morphologically comparable features’. It also highlighted the importance that such comparisons illustrate the significance of points of similarity and difference and that it must highlight presence and absence of features. Also highlighted in this report was the importance of probability factors and likelihood of features being present or absent in comparative images.
The presence of scarring on the dorsum of the hand has been utilised as a feature for consideration within the multifactorial process of hand image comparison. Within the Centre for Anatomy and Human Identification at the University of Dundee, image comparisons are undertaken of the anatomical features of the dorsum of the hand primarily for the purposes of comparing accused to offender images. In the majority of cases, these involve images of child sexual abuse where the dorsum of the hand of the perpetrator is present. The requirement for this form of analysis is on the increase with casework showing a tenfold rise in the past 5 years. The sharing of images of child pornography is recognised as one of the fastest-growing crimes of modern times [28, 29] with close to a million new photographs being posted on the Internet daily. Ease of access to the World Wide Web for the purposes of sharing images and the ease of availability of self-operated recording devices to perpetrators of sexual abuse is of concern to the law enforcement profession, as the sharing of images and the demand that is generated has added a new dimension to the social problem of child protection and the investigation and prosecution of child sexual offenses [30‐33].
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As scars are a common feature in the comparison of these images, it is essential that an understanding of their incidence is more fully understood. The aim of this research was to assess the incidence and position of scars on the dorsum of the hand to facilitate an understanding of the value of hand scars in the process of verification of identity. A subsequent publication will utilise this information and use it to construct likelihood ratios for current casework analysis.
Material and methods
The Centre for Anatomy and Human Identification at the University of Dundee holds an active database of hand images using both visual and infrared light. At the time of this research, the database consisted of images of pairs of hands from 260 individuals of both sexes drawn from a cadre of Disaster Victim Identification specialists undertaking training at the University of Dundee. The images were taken under good lighting conditions and at high resolution. Two hundred thirty-eight participants permitted personal information to be recorded, including sex and hand dominance, resulting in 177 males and 61 females (476 hands) being available for this research (Table 1). The age range for the sample was 21–62 years with a mean age of 43 years, and all participants were of European ancestry. As per the expected incidence, approximately 10 % were left-handed and close to 90 % were right-handed. Any individual with single or multiple digit amputations was not included nor were any individuals with developmental or congenital abnormalities.
Table 1
Sample separated according to hand dominance and sex
Right-handed
Left-handed
Ambidextrous
Total
Male
156
21
0
177
Female
55
5
1
61
Total
211
26
1
238
The dorsal surface of each hand was divided into 24 cells by way of a deformation grid, with each cell assigned an identification number (Fig. 1 and Table 2). Twenty-seven landmarks were selected to permit construction of this grid, and they were chosen because of their anatomical stability and visibility in all images. Once each hand was grid-mapped, then the presence of scarring was recorded (Fig. 2). For each hand, the number, type and approximate size of a scar was recorded for each of the 24 cells, for both the right and left hand of each individual.
Fig. 1
Location of the 27 hand landmarks and the formation of the deformation grid that arises from these to result in 24 grid cells for recording purposes
Table 2
Definition of the points that permit construction of the hand grid
Landmark
1
Most medial point on wrist constriction
2
Most lateral point on wrist constriction
3
Deepest point in the interdigital webbing between digits 1 and 2
4
Most lateral and prominent point over the 1st metacarpophalangeal (MCP) joint
5
Deepest point in the interdigital webbing between digits 2 and 3
6
Deepest point in the interdigital webbing between digits 3 and 4
7
Deepest point in the interdigital webbing between digits 4 and 5
8
Medial border of the base of digit 5 parallel to the MCP joint
9
Lateral border of base of digit 2 parallel to the MCP joint
10
Medial border of thumb parallel to the interphalangeal (IP) joint
11
Lateral border of the thumb parallel to the IP joint
12
Medial border of digit 5 parallel to the proximal interphalangeal (PIP) joint
13
Lateral border of digit 5 parallel to the PIP joint
14
Medial border of digit 4 parallel to the PIP joint
15
Lateral border of digit 4 parallel to the PIP joint
16
Medial border of digit 3 parallel to the PIP joint
17
Lateral border of digit 3 parallel to the PIP joint
18
Medial border of digit 2 parallel to the PIP joint
19
Lateral border of digit 2 parallel to the PIP joint
20
Medial border of digit 5 parallel to the distal interphalangeal (DIP) joint
21
Lateral border of digit 5 parallel to the DIP joint
22
Medial border of digit 4 parallel to the DIP joint
23
Lateral border of digit 4 parallel to the DIP joint
24
Medial border of digit 3 parallel to the DIP joint
25
Lateral border of digit 3 parallel to the DIP joint
26
Medial border of digit 2 parallel to the DIP joint
27
Lateral border of digit 2 parallel to the DIP joint
Fig. 2
Cropped image from the database of the right hand of a female participant. The deformation grid has been placed according to the landmark points (straight lines) and the positions of scars are outlined by black circles
×
×
The number of scars was a simple count of the scars present within a grid. If a scar crossed a grid line, it was recorded within the grid where the majority of the scar resided. Therefore, no scar was counted twice. Scar type referred to whether the scar was linear or non-linear in its presentation. Size of the scar was assessed using the photographic scale marker included in each image. Scars ≤5 mm were classified as small, scars between 6 and 9 mm were medium and scars ≥10 mm were recorded as being large. Only inactive scars were counted, and recent injuries to a hand that still showed inflammatory reactions were not included.
Results
Table 3 shows the distribution of scar incidence across the 24 grid cells in the right and left hands of the males and females from the sample. Linear and non-linear scars have been combined in this table so that a total of 251 scars were found in the male right sample (average of 1.42 scars per hand), 348 in the male left sample (average of 1.97 per hand), 95 in the female right sample (average of 1.56 per hand) and 51 in the female left sample (average of 0.84 per hand). Combining right and left hands resulted in an average of 3.38 scars for each male and 2.39 scars for each female. In reality, 49 % of male right hands did not show any scarring nor did 40 % of male left hands, 44 % of female right hands or 57 % of female left hands. Forty-five males were scar-free (25 % of male sample) showing scarring on neither their right nor their left hands whilst 16 females (26 % of female sample) were devoid of scarring on both hands. The largest number of scars seen in any one hand was 14 on a male right, 16 on a male left, 10 on a female right and 6 on a female left. The largest number of scars seen in the combined right and left hands of any individual was 23 on a male and 14 on a female. Mann–Whitney U testing showed that scars were more common in males than females (P < 0.001), more common in male rights than male lefts (P < 0.001) and more common in female lefts than in female rights (P < 0.001).
Table 3
Number of scars found in each cell separated for sex and side
Cell no.
Male right
Male left
Female right
Female left
1
4
21
5
1
2
4
13
4
3
3
13
13
6
8
4
4
2
0
2
5
3
1
0
0
6
2
4
0
0
7
14
31
13
3
8
6
9
4
1
9
26
18
7
6
10
0
4
0
1
11
10
19
5
2
12
17
25
7
4
13
17
13
7
3
14
3
2
3
1
15
8
16
3
2
16
4
9
2
1
17
27
34
13
3
18
23
32
7
3
19
12
8
2
0
20
7
10
0
0
21
22
18
3
2
22
11
18
4
5
23
12
13
0
0
24
2
15
0
0
Total
251
348
95
51
Using the data in Table 3, Fig. 3 was constructed to show where approximately 50 % of the scarring in each hand occurred. For male right hands, the highest incidence of scarring was found in grid cells 9, 17, 18 and 21 which equated to 39 % of scarring. To raise the total to 53 % scarring, grid cells 12 and 13 had to be added. For male left hands, the highest incidence of scarring was found in grid cells 7, 17 and 18 which equated to 28 % of all scarring. To raise the total to 56 % of all scarring, grid cells 1, 9, 12, 21 and 22 had to be added. For female right hands, the highest incidence of scarring was found in grid cells 7 and 17 which equated to 28 % of all scarring. To raise the total to 55 % of all scarring, grid cells 9, 12, 13 and 18 had to be added. For female left hands, the highest incidence of scarring occurred in grid cells 3, 9 and 22 which equated to 38 % of all scarring. To raise the total to 46 % required cells 2, 7, 12, 13, 17 and 18 to be added. When cells were examined for a common pattern in relation to where approximately 50 % of scarring occurs, grid cells 9, 12, 17 and 18 were common to all four groups (side and sex) and grid cells 7 and 13 were common to three of the four groups. Figure 3 shows the common positions within the hand for the incidence of scarring, so that the distal region of the hand appears to be more commonly scarred, particularly in relation to the index and middle fingers.
Fig. 3
Location of approximately 50 % of scarring on the dorsum of the hand in right and left hands of males and females
×
Figure 4 shows the location of what can be described as the medial border (grid cells 5, 10, 15, 20 and 24), the lateral border (grid cells 1, 6, 11 and 16), the index finger corridor (grid cells 7, 12, 17 and 21) and the middle finger corridor (grid cells 9, 13, 18 and 22). Table 4 shows the incidence and location of scars in these regions separated by sex and side. An average of 7 % of all scars occur along the medial border, 8.5 % along the lateral border, 31 % in the index finger corridor and 33 % in the middle finger corridor.
Fig. 4
Location of the medial and lateral border segments and the index and middle finger corridor regions
Table 4
Percentage incidence of scarring in different regions of the hand for rights and lefts in both sexes
Male
Female
Average
Right
Left
Right
Left
Index corridor cells 7, 12, 17, 21
32
31
38
24
31
Middle corridor cells 9, 13, 18, 22
31
23
45
33
33
Lateral border cells 1, 6, 11, 16
8
15
3
8
8.5
Medial border cells 5, 10, 15, 20, 24
8
13
3
4
7
×
Tables 5 and 6 show the incidence of scars in each of the 24 grid cells separated by scar type and size for males and females, respectively. Table 5 shows that, in the male right hand, linear scars are more than twice as common as non-linear scars and Mann–Whitney U tests show this to be highly significantly different (P < 0.001). Linear scars are most commonly found in grid cells 9, 12, 17, 18 and 21 whereas non-linear scars are most frequently found in grid cells 9 and 17. Small scars are the most common size (66 % of all scars in the male right hand) followed by medium scars (26 % of all scars), and large scars were least common (8 % of all scars). Small scars were most frequently found in grid cells 9, 17 and 21, with medium scars most frequently found in grid cells 3, 9 and 18. If large scars did occur, then they were most frequently found in grid cells 3 and 7. In the male left hand, linear scars were more common than non-linear scars by a factor of over 4, and Mann–Whitney U tests showed this to be highly significantly different (P < 0.001). Linear scars were found most frequently in grid cells 7, 12, 17 and 18 whereas non-linear scars were most frequently found in grid cells 1 and 18. Small scars were the most common (65 % of all scars) and were most frequently located in grid cells 12, 17 and 18. Medium scars were less common (24 % of all scars in the male left hand) and were most commonly found in grid cells 7 and 11 whereas large scars were the least common (11 % of all scars) and occurred most frequently in grid cell 1.
Table 5
Number of scars (linear and non-linear) in male right and left hands, in each cell, separated according to scar size
Cell no.
Male right
Male left
Linear
Non-linear
Small
Medium
Large
Linear
Non-linear
Small
Medium
Large
1
4
0
0
4
0
13
8
9
5
7
2
3
1
2
1
1
10
3
6
3
4
3
12
1
3
7
3
9
4
8
3
2
4
2
2
3
0
1
2
0
0
2
0
5
2
1
2
1
0
1
0
1
0
0
6
2
0
2
0
0
4
0
4
0
0
7
13
1
4
5
5
26
5
15
12
4
8
3
3
1
3
2
5
4
6
1
2
9
16
10
17
8
1
12
6
13
5
0
10
0
0
0
0
0
4
0
3
0
1
11
8
2
4
5
1
15
4
7
10
2
12
15
2
12
5
0
23
2
18
4
3
13
12
5
14
2
1
12
1
8
3
2
14
3
0
1
2
0
2
0
2
0
0
15
5
3
6
1
1
14
2
8
5
3
16
3
1
3
0
1
7
2
8
1
0
17
16
11
24
2
1
32
2
26
4
4
18
16
7
14
8
1
24
8
26
4
2
19
10
2
9
2
1
8
0
6
2
0
20
7
0
3
4
0
6
4
7
2
1
21
17
5
17
5
0
14
4
14
4
0
22
5
6
11
0
0
15
3
11
6
1
23
5
7
11
1
0
13
0
8
5
0
24
2
0
2
0
0
11
4
12
3
0
Total
181
70
165
66
20
282
66
226
84
38
Table 6
Number of scars (linear and non-linear) in female right and left hands, separate according to scar size
Cell no.
Female right
Female left
Linear
Lon-linear
Small
Medium
Large
Linear
Non-linear
Small
Medium
Large
1
5
0
1
3
1
1
0
1
0
0
2
2
2
3
1
0
2
1
3
0
0
3
5
1
1
4
1
5
3
4
3
1
4
0
0
0
0
0
2
0
0
1
1
5
0
0
0
0
0
0
0
0
0
0
6
0
0
0
0
0
0
0
0
0
0
7
9
4
10
2
1
3
0
1
2
0
8
3
1
3
0
1
1
0
0
0
1
9
6
1
6
0
1
1
5
6
0
0
10
0
0
0
0
0
0
1
1
0
0
11
5
0
5
0
0
2
0
1
1
0
12
5
2
5
2
0
2
2
2
2
0
13
5
2
5
2
0
3
0
3
0
0
14
3
0
3
0
0
1
0
1
0
0
15
3
0
1
1
1
2
0
1
1
0
16
1
1
1
1
0
1
0
1
0
0
17
9
4
9
3
1
2
1
2
1
0
18
5
2
6
1
0
3
0
3
0
0
19
2
0
1
1
0
0
0
0
0
0
20
0
0
0
0
0
0
0
0
0
0
21
2
1
3
0
0
2
0
2
0
0
22
3
1
2
2
0
5
0
1
4
0
23
0
0
0
0
0
0
0
0
0
0
24
0
0
0
0
0
0
0
0
0
0
Total
73
22
65
23
7
38
13
33
15
3
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Table 6 shows that, in the female right hand, linear scars are more than three times as common as non-linear scars, and Mann–Whitney U tests showed this to be highly significant (P < 0.001). Linear scars are most commonly found in grid cells 7 and 17, and although non-linear do not have a high occurrence, they tend to be found in the same grid cells as linear scars. Small scars are the most common size (68 % of all scars in the female right hand) followed by medium scars (24 % of all scars), and then large scars were least common (7 % of all scars). Small scars were most frequently found in grid cells 7 and 17 with medium and large scars not showing a particularly high incidence in any grid cell. In the female left hand, linear scars were more common than non-linear scars by a factor of almost 3, and again this reached statistical significance (P < 0.01). Linear scars were found most frequently in grid cells 3 and 22 whilst non-linear scars were most frequently found in grid cell 9. Small scars were the most common (65 % of all scars in the female left hand) and were most frequently located in grid cell 9. Medium scars were less common (29 % of all scars), and large scars were the least common (6 % of all scars). The incidence of medium and large scars did not permit identification of a most frequent grid cell.
Only three individuals presented with identifiable surgical scars (1.3 % of the total sample), and all were found in males and classified as large scars. One was located on the left hand in grid cell 3, and the other two were located on the right and in grid cells 3 and 4.
Discussion
The phrase ‘the hand is the window onto the mind’ has been attributed to the German philosopher Immanuel Kant from around 1798 [34, 35], and certainly, the analysis of the hand has intrigued science and the public alike through their portrayal in both art and literature. That the intimate anatomy of the hand can be of investigative value was exploited by Conan Doyle in his novel ‘A study in scarlet’ where Holmes pontificated that ‘By a man's finger-nails, by his coat-sleeve, by his boots, by his trouser-knees, by the callosities of his forefinger and thumb, by his expression, by his shirt-cuff—By each of these things a man's calling is plainly revealed.’[36]. Whilst neither finger callosities nor nails form the core of this investigation, it is evident that the persistent scars on the back of the hand paint an interesting picture in terms of marks that can be utilised as present or absent morphological features in the comparison of images for the purposes of verification of identity.
Previous research has indicated that males are more likely to present a larger number of scars than females, and their location will be influenced by the dominance of the hand [12, 15, 19]. The results of this study agree with this in part. Approximately 50 % more scars occurred in male hands than in female hands. Interestingly, although males showed a greater incidence on their left hands, females showed a greater incidence on their right hands. This is unlikely to be explained by hand dominance as it was shown in Table 1 that the percentage of hand dominance was similar in the two groups and agreed with the general literature. Therefore, there is a suggestion that the male left hand which is usually the non-dominant hand is more prone to injury than the dominant hand (right) whilst the reverse is the situation for females with the dominant hand being more susceptible to injury. It is possible that this result reflects differences in the type of injuries sustained by males and females [12, 18], and although this seems like a very stereotypical explanation, it is difficult to find a reasonable alternative other than males are more likely to scar their non-dominant hand as a result of perhaps injury caused by an implement in the dominant hand, whereas female scarring is less implement-based and more accidental in aetiology as described by Hill et al. [12].
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It would appear from this research that, perhaps as expected, surgical scars are rare within the data base sample, and when they do occur, they are most commonly represented in cells 3 and 4. The most common hand surgery is largely concerned with degenerative change including median nerve compression and arthritis [19], and this is more common in an elderly sample than is perhaps represented by the database cohort. On the dorsum of the hand, surgical intervention scars occur most frequently over the joint regions to address arthroplasty, but in this research, the most common surgical scars were in the region over the intercarpal joints. The database is not necessarily representative of the general population, and it is important that the database be increased significantly so that comparisons may be made within appropriate populational sectors.
For the purposes of verification of identity, it has been shown that non-linear scars are less common as are scars in excess of 6 mm. Therefore, these categories may initially be thought of as being of greater discriminatory value, but in reality the multiplicity of small scars (such as seen in Fig. 2) and their random placing due to their accidental nature resulted in no multiple scar patterning within the database being identical to any other. Therefore, whilst in isolation, the larger and non-linear scars may prove to be of greater value; the pattern of location of two or more small scars has proved to be of considerable importance in the formation of a two-dimensional locational map.
Contrary to the findings of Rosberg and Dahlin [15], the medial and lateral borders of the hand are not the most common location for the persistence of scarring in this sample. Only 7–8 % of all scarring occurred along a hand border, and this was equally true for males and females and for rights and lefts. However, the highest incidence of scarring occurred along the index and middle corridor regions, where 64 % of all scarring in the hand was located. This is a clear indication that a large proportion of the scarring found in this sample has resulted from interaction injury with both dominant and non-dominant fingers being susceptible to small scale traumas.
For the purposes of image comparison, scars are a useful trait to examine for presence or absence, similarity or differences in shape, size and position. They are most commonly accidental in nature and therefore not predictable per se, although the incidence of scarring along the index and middle fingers is likely to be higher than in any other part of the hand. In males, scars are more likely to occur in the index and middle finger corridors of the non-dominant hand, and in the majority of casework undertaken, we have identified that it is the left non-dominant hand of the perpetrator that tends to be captured in images, and in the majority of cases, it is the thumb, index and middle finger regions that are most frequently observed. Therefore, it is exceptionally important to be aware of the incidence of scarring in this region in the general population and how that might relate to the profile of the offender hand [37, 38]. It is accepted that the occupational origin of the individuals within a database will be important as it is likely that the more manual work that is undertaken then the greater will be the incidence of scarring. The database utilised in this communication is of considerable value, but ongoing additions to the resource from different societal sectors will allow future inferences to be made regarding the incidence of scarring in different groups. The subsequent paper will examine current casework and the probability that the perpetrator and suspect was the same person, based solely on scar-related information sourced from this communication. It is essential that the anatomical interpretation of features of the hand is fully documented if expert opinions are to be proffered on the likelihood of two individuals showing matching features.
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Um auch an kleinen Gewebeproben zuverlässige und reproduzierbare Ergebnisse zu gewährleisten ist eine strenge Qualitätskontrolle in jedem Schritt des Arbeitsablaufs erforderlich. Eine nicht ordnungsgemäße Prüfung oder Behandlung des …
Die vergleichende experimentelle Pathologie („comparative experimental pathology“) ist ein Fachbereich an der Schnittstelle von Human- und Veterinärmedizin. Sie widmet sich der vergleichenden Erforschung von Gemeinsamkeiten und Unterschieden von …
Gastrointestinale Stromatumoren (GIST) stellen seit über 20 Jahren ein Paradigma für die zielgerichtete Therapie mit Tyrosinkinaseinhibitoren dar. Eine elementare Voraussetzung für eine mögliche neoadjuvante oder adjuvante Behandlung bei …
Aufgrund des erheblichen technologischen Fortschritts in der molekularen und genetischen Diagnostik sowie zunehmender Erkenntnisse über die molekulare Pathogenese von Krankheiten hat in den letzten zwei Jahrzehnten ein grundlegender …
