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Pediatric Nephrology
Erschienen in: Pediatric Nephrology 7/2014

01.07.2014 | Review

The innate immune response during urinary tract infection and pyelonephritis

verfasst von: John David Spencer, Andrew L. Schwaderer, Brian Becknell, Joshua Watson, David S. Hains

Erschienen in: Pediatric Nephrology | Ausgabe 7/2014

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Abstract

Despite its proximity to the fecal flora, the urinary tract is considered sterile. The precise mechanisms by which the urinary tract maintains sterility are not well understood. Host immune responses are critically important in the antimicrobial defense of the urinary tract. During recent years, considerable advances have been made in our understanding of the mechanisms underlying immune homeostasis of the kidney and urinary tract. Dysfunctions in these immune mechanisms may result in acute disease, tissue destruction and overwhelming infection. The objective of this review is to provide an overview of the innate immune response in the urinary tract in response to microbial assault. In doing so, we focus on the role of antimicrobial peptides—a ubiquitous component of the innate immune response.
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Metadaten
Titel
The innate immune response during urinary tract infection and pyelonephritis
verfasst von
John David Spencer
Andrew L. Schwaderer
Brian Becknell
Joshua Watson
David S. Hains
Publikationsdatum
01.07.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Nephrology / Ausgabe 7/2014
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-013-2513-9

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