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Erschienen in: Journal of Cardiovascular Translational Research 4/2012

01.08.2012

The Landmark JDRF Continuous Glucose Monitoring Randomized Trials: a Look Back at the Accumulated Evidence

verfasst von: Katrina J. Ruedy, William V. Tamborlane, for the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group

Erschienen in: Journal of Cardiovascular Translational Research | Ausgabe 4/2012

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Abstract

Despite improvements for management of type 1 diabetes (T1D), patients have difficulty achieving glycated hemoglobin (A1c) levels recommended by the Diabetes Control and Complications Trial (DCCT). Two multicenter randomized trials were conducted to evaluate benefit of using a continuous glucose monitor (CGM) with standard glucose monitoring for T1D management. The primary study evaluated benefits of CGM in 322 patients with A1c >7.0 %. The secondary study evaluated 129 patients with A1c <7.0 %. In the primary study, CGM resulted in improvements in A1c at 6 m in subjects >25 years, but not those <25. However, all subjects using CGM regularly showed benefit. Improved A1c did not come with increased severe hypoglycemia as seen in the DCCT, and benefit was sustained over 1 year. In the secondary study, CGM use helped subjects maintain target A1c levels with reduced exposure to biochemical hypoglycemia. The data collected allowed for other analyses of important factors in T1D management.
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Metadaten
Titel
The Landmark JDRF Continuous Glucose Monitoring Randomized Trials: a Look Back at the Accumulated Evidence
verfasst von
Katrina J. Ruedy
William V. Tamborlane
for the Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group
Publikationsdatum
01.08.2012
Verlag
Springer US
Erschienen in
Journal of Cardiovascular Translational Research / Ausgabe 4/2012
Print ISSN: 1937-5387
Elektronische ISSN: 1937-5395
DOI
https://doi.org/10.1007/s12265-012-9364-9

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