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Inflammopharmacology

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27.01.2021 | Editorial

The life and works of Dr Brian Bernard Newbould (28nd Jan 1934-25th Nov, 2016) B. Pharm, FR PharmS, PhD

verfasst von: K. D. Rainsford

Erschienen in: Inflammopharmacology | Ausgabe 2/2021

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Brian Newbould was a unique research scientist of high standing and a scientific administrator who spent most of his working life in the pharmaceutical industry (ICI Pharmaceuticals Division (ICI plc) Macclesfield, UK, which in 1990 became Zeneca Ltd). Most of his research and direction was devoted to the development of anti-arthritic agents and drugs affecting the endocrine and immune systems. These contributions are celebrated here along with the extensive support he gave to research organizations and individuals as well as in academic leadership and in promotion of high standards in academe and industry. Brian was especially generous in giving clear and invaluable advice to colleagues and showed inspired thinking and direction of research in his field. …

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Chalmers TM, Kellgren JH, Platt DS (1969) Evaluation in man of fenclozic acid (ICI 54,450, Myelex), a new anti-inflammatory agent. Clin Ann Rheum Dis 28:295

Dudley Hart F, Bain LS, Huskisson EC, Littler TR, Taylor RT (1970) Hepatic effects of fenclozic acid. Ann Rheum Dis 29:684CrossRef

Franklin TJ, Newbould BB, O’Mant DM, Scott AI, Stacey GJ, Davies GE (1966) A new type of cytotoxic immunosuppressive agent: 3-acetyl-5-(4-fluorobenzylidene)-4-hydroxy-2-oxo-2:5-dihyrothiopen. Nature 210:638–639CrossRef

Hepworth W, Newbould BB, Platt DS, Stacey GJ (1968) Studies with certain anti-inflammatory and immune-suppressive agents on adjuvant-induced arthritis in rats and other experimental models. Proc Joint Meeting between the Italian and Br Pharmacol Soc

Hepworth W, Newbould BB, Platt DS, Stacey GJ (1968) 2-(4-chlorophenyl) thiazol-4-yl acetic acid (‘MYALEX’) A new compound with anti-inflammatory, analgesic and anti-pyretic activity. Nat London 221:582–583CrossRef

Koga T, Sande BV, Yeaton R, Pearson CM (1976) Re-evaluation of inguinal lymph node injection for the production of adjuvant arthritis in the rats. Int Arch Allergy Appl Immunol 51:359–367CrossRef

Morgan GJ, Peter JB, Newbould BB (1969) Experimental polymyositis. Arth Rheumat 12:317 (Abstract)

Morgan GJ, Peter JB, Newbould BB (1971) Experimental allergic myositis in rats. Arthr Rheum 14:599CrossRef

Newbould BB (1963) Chemotherapy of arthritis induced in rates by mycobacterial adjuvant. Br J Pharmacol Chem 21:127–136 (621 Citation)

Newbould BB (1963a) Adjuvant-induced arthritis in rats. Proc 1963 Meeting of the British Pharmacological society

Newbould BB (1964) Lymphatic drainage and adjuvant-induced arthritis in rats. Br J Exp Pathol 45:375–383PubMedPubMedCentral

Newbould BB (1964a) The role of lymph nodes in the development of adjuvant-induced arthritis in rats. Proc British Society for Immunology

Newbould BB (1964c) Role of lymph nodes in adjuvant-induced arthritis in rats. Ann Rheumat Dis

Newbould BB (1964d) Chemotherapeutic suppression of adjuvant-induced arthritis in rats. Br Soc Immunol

Newbould BB (1965a) Production of experimental allergic encephalomyelitis in rats by injections of spinal cord adjuvant into the inguinal lymph nodes. Immunology 9:613–614PubMedCentral

Newbould BB (1965b) Chemotherapeutic studies on adjuvant-induced arthritis and allergic encephalomyeltis. Br Pharmacol Soc 12:9–34

Newbould BB (1965c) Suppression of adjuvant-induced arthritis in rats with 2-butoxy carbonyl methylene-4-oxo thiazolidine. Br J Pharmacol Chemother 24:632–640CrossRef

Newbould BB (1966a) Production of allergic encephalomyelitis and other syndromes involving an immune response by intra-lymph node injection of antigen/adjuvant emulsions. Br Soc Immunol

Newbould BB (1966b) Studies with 3-acetyl-5-(4-fluorobenzylidene)-4-hydroxy-2-oxo-2:5-dihyrothiopen (ICI 47,776) on adjuvant induced arthritis allergic encephalomyelitis and allergic thyroiditis in rats. Br Soc Immunol

Newbould BB (1967) The evaluation and potential utility of compounds which modify the development of adjuvant disease in rats. Invited Am Chem Soc Symp Anti Inflam Comp

Newbould BB (1968a) Attempted inhibition of adjuvant-induced arthritis allergic encephalomyelitis and allergic thyroiditis in rats with certain antisera and chemotherapeutic agents. Proc Meeting of the British Society for Immunology

Newbould BB (1968b) Studies on adjuvant-induced arthritis in rats. Proc International Symposium of Inflammation Biochemistry and Drug Interaction – Como – October 1968

Newbould BB (1969a) Selective suppression with rabbit anti-rat thymocyte serum and rabbit anti-tuberculous serum of adjuvant-induced arthritis (AIA); Expt allergic encephalomyelitis (EAE) and Expt allergic thyroiditis in rats. Arth Rheum 12:31

Newbould BB (1969b) The Phamacology of 2-(4-chlorophenyl) thiazol-4-yl acetic acid (ICI 54,540; ‘MYALEX’); a new compound with anti-inflammatory, analgesic and anti-pyretic activity. Br J Phamacol 35:487–489CrossRef

Newbould BB (1980) Risk benefit analysis in drug research: the effect on industry. Proc Society for Drug Res Canterbury

Newbould BB (1981) Implications for management of new directions in pharmaceutical research. Proc Pharma 81:12

Newbould B B (1981) How does marketing research serve the needs of new product research and development. Proc Market Research Meeting Industrial Pharmacists Group London

Newbould BB (1981) Does regulatory control influence the search for new drugs? Proc Br Instit Regu Affairs Symp Guildford

Newbould BB (1986) Life Sciences Phamaceuticals. Proc Anglo-Japn High Technol Industrial Forum

Newbould BB (1986) The future of drug discovery. Proc Society For Drug Research – London

Newbould B (1986) The Innovation Process – A British Example. Proc Anglo-Japanese High Technology Industrial Forum

Newbould BB (1989) Research results and business success. Proc Management Centre Europe – Zurich –

Newbould BB (1989) ICI Pharmaceuticals. Proc Asian Medical News 10th Anniversary Edition – March 1989

Newbould, B B. (1989) Future Trends in World-wide Pharmaceutical R&D. Proc Future Trends in Pharmaceutical Research Seminar – Bangkok – Thailand – April 1989

Newbould BB (1990) How are medicines discovered? Chapter book – Pharmaceutical Medicine

Newbould BB (1992) The birth and growth of the pharmaceutical industry. Proc Duncan Davies Memorial Medal Lecture at the Research and Development Society

Newbould BB (1993) Eastern European R&D Resources – A Challenge for EIMRA Members. Contribution on Experience to Round Table Meeting – France

Newbould, B B. (1993) The industrialist’s perception of post-16 education and training. Proc Ann Assoc Sci

Newbould BB, Kilpatrick R (1959) Some information on long acting sulphonamides. Proc 1959 Meeting of the British Pharmacological Society

Newbould BB, Kilpatrick R (1959) The inhibitory effect of plasma proteins on the antibacterial activity of some new sulphonamides. Proc 1959 of the British Phamacological Society

Newbould BB, Kilpatrick R (1960) Long-acting sulphonamides and protein-binding. Lancet 1960(1):887–891CrossRef

Newbould BB, Philipps NJ (1992) (1992) An industrial perspective – The ICI View. Biologist 39:5

Newbould BB, Pearson CM, Whitehouse MW (2019) Passive transfer of allergic encephalomyelitis in rats—a tool for detecting late-acting immunosuppressants. Inflammopharmacology. https://doi.org/10.1007/s10787-019-00565-w (in press)

Pearson CM (1956) Development of arthritis, periarthritis and periostosis in rats given adjuvants. Proc Soc exp Biol 91:95–101CrossRef

Pearson CM (1959) Development of arthritis in the rat following injection with adjuvant. In: Shaffer JH, Lo Grippo GA, Chase MW (eds) Mechanisms of hypersensitivity. Little Brown, Boston

Pearson CM, Newbould BB, Whitehouse DJ, Whitehouse M (1969) Conditions required for the cell mediated transfer of adjuvant-induced arthritis, allergic encephalomyelitis and allergic thyroiditis. Arth Rheum 12:322

Pearson CM (1976) Lymphocyte depletion in patients with rheumatoid arthritis. Agents Actions 6:28–31CrossRef

Pearson CM, Wood FD (1959) Studies of polyarthritis and other lesions induced in rats by injection of mycobacterial adjuvant. General clinical and pathological characteristics and some modifying factors. Arth Rheum 2:440–459CrossRef

Pearson CM, Wood FD (1963) Studies of arthritis and other lesions in rats by the injection of mycobacterial adjuvant VII. Pathologic details of the arthritis and spondylitis. Am J Path 42:73–95PubMed

Rodrigues AVM, Rollison HE, Martin S, Sarda S, Schulz-Utermochl SSS, Gustafsson F, Eakins J, Kenna JG, Wilson ID (2013) In vitro exploration of potential mechanisms of toxicity of the human hepatotoxic drug fenclozic acid. Arch Toxicol 87:1569–1579CrossRef

Sokoloff MC, Newbould BB (1970) Suppression of experimental allergic encephalomyelitis (EAE) by methotrexate (MTX) with Folinic Acid (FA) rescue. Arthritis Rheum 13:350CrossRef

Stoerk HC, Bielinski TC, Budzilovich T (1954) Chronic polyarthritis in rats injected with spleen in adjuvants. Am J Path 30:616

Whitehouse DJ, Whitehouse MW, Pearson CM (1969) Passive transfer of adjuvant-induced arthritis and allergic encephalomyelitis in rats using thoracic duct lymphocytes. Nature 224:1322CrossRef

Whitehouse MW (2007) Adjuvant arthritis 50 years on: the impact of the 1956 article by CM Pearson: Development of arthritis, periarthritis and periostitis in rats given adjuvants. Inflamm Res 56:133–138CrossRef

Titel: The life and works of Dr Brian Bernard Newbould (28nd Jan 1934-25th Nov, 2016) B. Pharm, FR PharmS, PhD
verfasst von: K. D. Rainsford
Publikationsdatum: 27.01.2021
Verlag: Springer International Publishing
Erschienen in: Inflammopharmacology / Ausgabe 2/2021
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-020-00778-4

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

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The life and works of Dr Brian Bernard Newbould (28nd Jan 1934-25th Nov, 2016) B. Pharm, FR PharmS, PhD

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Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

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