Skip to main content
Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy 9/2008

01.09.2008 | Knee

The location-specific healing response of damaged articular cartilage after ACL reconstruction: short-term follow-up

verfasst von: Norimasa Nakamura, Shuji Horibe, Yukiyoshi Toritsuka, Tomoki Mitsuoka, Takashi Natsu-ume, Kenji Yoneda, Masayuki Hamada, Yoshinari Tanaka, Richard S. Boorman, Hideki Yoshikawa, Konsei Shino

Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy | Ausgabe 9/2008

Einloggen, um Zugang zu erhalten

Abstract

Although many different interventions have been proposed for treating cartilage lesions at the time of ACL reconstruction, the normal healing response of these injuries has not been well documented. To address this point, we compared the arthroscopic status of chondral lesions at the time of ACL reconstruction with that obtained at second-look arthroscopy. We hypothesized that there might be a location-specific difference in the healing response of damaged articular cartilage. Between September 1998 and March 2000, 383 patients underwent arthroscopically-assisted hamstring ACL reconstruction without any intervention to the articular cartilage. Among these patients, 84 patients underwent second-look arthroscopy (ranging from 6 to 52 months following initial surgery) and make up the population of the present study. Chondral injuries, left untreated at ACL reconstruction, were arthroscopically evaluated using the Outerbridge classification, and were again evaluated at second-look arthroscopy. At second-look arthroscopy, there was significant recovery of chondral lesions by Outerbridge grading on both the medial and lateral femoral condyles. Among the recovered chondral lesions, 69% of cases of the medial femoral condyle, 88% of cases of the lateral femoral condyle were partial thickness injuries (grade I and II). Conversely, there was no significant recovery of chondral lesions observed at the patello-femoral joint or tibial plateaus. Our study revealed that there was a location-specific difference in the natural healing response of chondral injury. Untreated cartilage lesions on the femoral condlyes had a superior healing response compared to those on the tibial plateaus, and in the patello-femoral joint.
Literatur
1.
Zurück zum Zitat Buckwalter JA, Mankin HJ (1997) Articular cartilage: part II: degeneration and osteoarthritis, repair, regeneration, and transplantation. J Bone Joint Surg Am 79:612–632 Buckwalter JA, Mankin HJ (1997) Articular cartilage: part II: degeneration and osteoarthritis, repair, regeneration, and transplantation. J Bone Joint Surg Am 79:612–632
2.
Zurück zum Zitat Newman AP (1998) Articular cartilage repair. Am J Sports Med 26:309–324PubMed Newman AP (1998) Articular cartilage repair. Am J Sports Med 26:309–324PubMed
3.
Zurück zum Zitat Hunziker EB (2002) Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthr Cartil 10:432–463PubMedCrossRef Hunziker EB (2002) Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthr Cartil 10:432–463PubMedCrossRef
4.
Zurück zum Zitat Landells JW (1957) The reactions of injured human articular cartilage. J Bone Joint Surg Br 39:548–562PubMed Landells JW (1957) The reactions of injured human articular cartilage. J Bone Joint Surg Br 39:548–562PubMed
5.
Zurück zum Zitat DePalma AF, McKeever CD, Subin DK (1966) Process of repair of articular cartilage demonstrated by histology and autoradiography with tritiated thymidine. Clin Orthop 48:229–242PubMed DePalma AF, McKeever CD, Subin DK (1966) Process of repair of articular cartilage demonstrated by histology and autoradiography with tritiated thymidine. Clin Orthop 48:229–242PubMed
6.
Zurück zum Zitat Fuller JA, Ghadially FN (1972) Ultrastructural observations on surgically produced partial-thickness defects in articular cartilage. Clin Orthop 86:193–205PubMedCrossRef Fuller JA, Ghadially FN (1972) Ultrastructural observations on surgically produced partial-thickness defects in articular cartilage. Clin Orthop 86:193–205PubMedCrossRef
7.
Zurück zum Zitat Ghadially FN, Thomas I, Oryschak AF, Lalonde JM (1977) Long-term results of superficial defects in articular cartilage: a scanning electron-microscope study. J Pathol 121:213–217PubMedCrossRef Ghadially FN, Thomas I, Oryschak AF, Lalonde JM (1977) Long-term results of superficial defects in articular cartilage: a scanning electron-microscope study. J Pathol 121:213–217PubMedCrossRef
8.
Zurück zum Zitat Hunziker EB, Rosenberg LC (1996) Repair of partial-thickness defects in articular cartilage: cell recruitment from the synovial membrane. J Bone Joint Surg Am 78:721–733PubMed Hunziker EB, Rosenberg LC (1996) Repair of partial-thickness defects in articular cartilage: cell recruitment from the synovial membrane. J Bone Joint Surg Am 78:721–733PubMed
9.
Zurück zum Zitat Noyes FR, Bassett RW, Grood ES, Butler DL (1980) Arthroscopy in acute traumatic hemarthrosis of the knee. Incidence of anterior cruciate tears and other injuries. J Bone Joint Surg Am 62:687–695PubMed Noyes FR, Bassett RW, Grood ES, Butler DL (1980) Arthroscopy in acute traumatic hemarthrosis of the knee. Incidence of anterior cruciate tears and other injuries. J Bone Joint Surg Am 62:687–695PubMed
10.
Zurück zum Zitat Indelicato PA, Bittar ES (1985) A perspective of lesions associated with ACL insufficiency of the knee. A review of 100 cases. Clin Orthop Relat Res 198:77–80PubMed Indelicato PA, Bittar ES (1985) A perspective of lesions associated with ACL insufficiency of the knee. A review of 100 cases. Clin Orthop Relat Res 198:77–80PubMed
11.
Zurück zum Zitat Hirshman HP, Daniel DM, Miyasaka K (1990) The fate of unoperated knee ligament injuries. In: Daniel DM, Akeson WH, O’Connor JJ (eds) Knee ligaments: structure, function, injury and repair. Raven Press, New York, pp 481–503 Hirshman HP, Daniel DM, Miyasaka K (1990) The fate of unoperated knee ligament injuries. In: Daniel DM, Akeson WH, O’Connor JJ (eds) Knee ligaments: structure, function, injury and repair. Raven Press, New York, pp 481–503
12.
Zurück zum Zitat DeHaven KE (1980) Diagnosis of acute knee injuries with haemarthrosis. Am J Sports Med 8:9–14PubMedCrossRef DeHaven KE (1980) Diagnosis of acute knee injuries with haemarthrosis. Am J Sports Med 8:9–14PubMedCrossRef
13.
Zurück zum Zitat Fowler PJ, Messieh SS (1987) Isolated posterior cruciate ligament injuries in athletes. Am J Sports Med 15:553–557PubMedCrossRef Fowler PJ, Messieh SS (1987) Isolated posterior cruciate ligament injuries in athletes. Am J Sports Med 15:553–557PubMedCrossRef
14.
Zurück zum Zitat Alfredson H, Thorsen K, Lorentzon R (1999) Treatment of tear of the anterior cruciate ligament combined with localised deep cartilage defects in the knee with ligament reconstruction and autologous periosteum transplantation. Knee Surg Sports Traumatol Arthrosc 7:69–74PubMedCrossRef Alfredson H, Thorsen K, Lorentzon R (1999) Treatment of tear of the anterior cruciate ligament combined with localised deep cartilage defects in the knee with ligament reconstruction and autologous periosteum transplantation. Knee Surg Sports Traumatol Arthrosc 7:69–74PubMedCrossRef
15.
Zurück zum Zitat Bobic V (1996) Arthroscopic osteochondral autograft transplantation in anterior cruciate ligament reconstruction: a preliminary clinical study. Knee Surg Sports Traumatol Arthrosc 3:262–264PubMedCrossRef Bobic V (1996) Arthroscopic osteochondral autograft transplantation in anterior cruciate ligament reconstruction: a preliminary clinical study. Knee Surg Sports Traumatol Arthrosc 3:262–264PubMedCrossRef
16.
Zurück zum Zitat Klinger HM, Baums MH, Otte S, Steckel H (2003) Anterior cruciate reconstruction combined with autologous osteochondral transplantation. Knee Surg Sports Traumatol Arthrosc 11:366–371PubMedCrossRef Klinger HM, Baums MH, Otte S, Steckel H (2003) Anterior cruciate reconstruction combined with autologous osteochondral transplantation. Knee Surg Sports Traumatol Arthrosc 11:366–371PubMedCrossRef
17.
Zurück zum Zitat Peterson L, Minas T, Brittberg M, Nilsson A, Sjogren-Jansson E, Lindahl A (2000) Two- to 9-year outcome after autologous chondrocyte transplantation of the knee. Clin Orthop Relat Res 374:212–234PubMedCrossRef Peterson L, Minas T, Brittberg M, Nilsson A, Sjogren-Jansson E, Lindahl A (2000) Two- to 9-year outcome after autologous chondrocyte transplantation of the knee. Clin Orthop Relat Res 374:212–234PubMedCrossRef
18.
Zurück zum Zitat Amin AA, Bartlett W, Gooding CR, Sood M, Skinner JA, Carrington RW, Briggs TW, Bentley G (2006) The use of autologous chondrocyte implantation following and combined with anterior cruciate ligament reconstruction. Int Orthop 30:48–53PubMedCrossRef Amin AA, Bartlett W, Gooding CR, Sood M, Skinner JA, Carrington RW, Briggs TW, Bentley G (2006) The use of autologous chondrocyte implantation following and combined with anterior cruciate ligament reconstruction. Int Orthop 30:48–53PubMedCrossRef
19.
Zurück zum Zitat Hangody L, Fules P (2003) Autologous osteochondral mosaicplasty for the treatment of full-thickness defects of weight-bearing joints: ten years of experimental and clinical experience. J Bone Joint Surg Am 85(Suppl 2):25–32PubMed Hangody L, Fules P (2003) Autologous osteochondral mosaicplasty for the treatment of full-thickness defects of weight-bearing joints: ten years of experimental and clinical experience. J Bone Joint Surg Am 85(Suppl 2):25–32PubMed
20.
Zurück zum Zitat Toritsuka Y, Shino K, Horibe S, Mitsuoka T, Hamada M, Nakata K, Nakamura N, Yoshikawa H (2004) Second-look arthroscopy of anterior cruciate ligament grafts with multistranded hamstring tendons. Arthroscopy 20:287–293PubMedCrossRef Toritsuka Y, Shino K, Horibe S, Mitsuoka T, Hamada M, Nakata K, Nakamura N, Yoshikawa H (2004) Second-look arthroscopy of anterior cruciate ligament grafts with multistranded hamstring tendons. Arthroscopy 20:287–293PubMedCrossRef
21.
Zurück zum Zitat Outerbridge RE (1961) The etiology of chondromalacia patellae. J Bone Joint Surg Br 43:752–757PubMed Outerbridge RE (1961) The etiology of chondromalacia patellae. J Bone Joint Surg Br 43:752–757PubMed
22.
Zurück zum Zitat Wozney JM, Rosen V, Byrne M, Celeste AJ, Moutsatsos I, Wang EA (1990) Growth factors influencing bone development. J Cell Sci Suppl 13:149–156PubMed Wozney JM, Rosen V, Byrne M, Celeste AJ, Moutsatsos I, Wang EA (1990) Growth factors influencing bone development. J Cell Sci Suppl 13:149–156PubMed
23.
Zurück zum Zitat Eppley BL, Woodell JE, Higgins J (2004) Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg 114:1502–1508PubMedCrossRef Eppley BL, Woodell JE, Higgins J (2004) Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg 114:1502–1508PubMedCrossRef
24.
Zurück zum Zitat Prockop DJ (1997) Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276:71–74PubMedCrossRef Prockop DJ (1997) Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276:71–74PubMedCrossRef
25.
Zurück zum Zitat De Bari C, Dell’Accio F, Tylzanowski P, Luyten FP (2001) Multipotent mesenchymal stem cells from adult human synovial membrane. Arthritis Rheum 44:1928–1942PubMedCrossRef De Bari C, Dell’Accio F, Tylzanowski P, Luyten FP (2001) Multipotent mesenchymal stem cells from adult human synovial membrane. Arthritis Rheum 44:1928–1942PubMedCrossRef
26.
Zurück zum Zitat Wickham MQ, Erickson GR, Gimble JM, Vail TP, Guilak F (2003) Multipotent stromal cells derived from the infrapatellar fat pad of the knee. Clin Orthop 412:196–212PubMedCrossRef Wickham MQ, Erickson GR, Gimble JM, Vail TP, Guilak F (2003) Multipotent stromal cells derived from the infrapatellar fat pad of the knee. Clin Orthop 412:196–212PubMedCrossRef
27.
Zurück zum Zitat Roufosse CA, Direkze NC, Otto WR, Wright NA (2004) Circulating mesenchymal stem cells. Int J Biochem Cell Biol 36:585–597PubMedCrossRef Roufosse CA, Direkze NC, Otto WR, Wright NA (2004) Circulating mesenchymal stem cells. Int J Biochem Cell Biol 36:585–597PubMedCrossRef
28.
Zurück zum Zitat Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284:143–147PubMedCrossRef Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284:143–147PubMedCrossRef
29.
Zurück zum Zitat Arnoczky SP, Rubin RM, Marshall JL (1979) Microvasculature of the cruciate ligaments and its response to injury. An experimental study in dogs. J Bone Joint Surg Am 61:1221–1229PubMed Arnoczky SP, Rubin RM, Marshall JL (1979) Microvasculature of the cruciate ligaments and its response to injury. An experimental study in dogs. J Bone Joint Surg Am 61:1221–1229PubMed
30.
Zurück zum Zitat Maekawa K, Furukawa H, Kanazawa Y, Hijioka A, Suzuki K, Fujimoto S (1996) Electron and immunoelectron microscopy on healing process of the rat anterior cruciate ligament after partial transection: the roles of multipotent fibroblasts in the synovial tissue. Histol Histopathol 11:607–619PubMed Maekawa K, Furukawa H, Kanazawa Y, Hijioka A, Suzuki K, Fujimoto S (1996) Electron and immunoelectron microscopy on healing process of the rat anterior cruciate ligament after partial transection: the roles of multipotent fibroblasts in the synovial tissue. Histol Histopathol 11:607–619PubMed
31.
Zurück zum Zitat Murray MM, Martin SD, Martin TL, Spector M (2000) Histological changes in the human anterior cruciate ligament after rupture. J Bone Joint Surg Am 82:1387–1397PubMed Murray MM, Martin SD, Martin TL, Spector M (2000) Histological changes in the human anterior cruciate ligament after rupture. J Bone Joint Surg Am 82:1387–1397PubMed
32.
Zurück zum Zitat Arnoczky SP, Warren RF, Spivak JM (1988) Meniscal repair using an exogenous fibrin clot. An experimental study in dogs. J Bone Joint Surg Am 70:1209–1217PubMed Arnoczky SP, Warren RF, Spivak JM (1988) Meniscal repair using an exogenous fibrin clot. An experimental study in dogs. J Bone Joint Surg Am 70:1209–1217PubMed
33.
Zurück zum Zitat Kimura M, Shirakura K, Hasegawa A, Kobuna Y, Niijima M (1995) Second look arthroscopy after meniscal repair. Factors affecting the healing rate. Clin Orthop Relat Res 314:185–191PubMed Kimura M, Shirakura K, Hasegawa A, Kobuna Y, Niijima M (1995) Second look arthroscopy after meniscal repair. Factors affecting the healing rate. Clin Orthop Relat Res 314:185–191PubMed
34.
Zurück zum Zitat Miyamoto A, Deie M, Yamasaki T, Nakamae A, Shinomiya R, Adachi N, Ochi M (2007) The role of the synovium in repairing cartilage defects. Knee Surg Sports Traumatol Arthrosc 15:1083–1093PubMedCrossRef Miyamoto A, Deie M, Yamasaki T, Nakamae A, Shinomiya R, Adachi N, Ochi M (2007) The role of the synovium in repairing cartilage defects. Knee Surg Sports Traumatol Arthrosc 15:1083–1093PubMedCrossRef
35.
Zurück zum Zitat Cameron ML, Briggs KK, Steadman JR (2003) Reproducibility and reliability of the Outerbridge classification for grading chondral lesions of the knee arthroscopically. Am J Sports Med 31:83–86PubMed Cameron ML, Briggs KK, Steadman JR (2003) Reproducibility and reliability of the Outerbridge classification for grading chondral lesions of the knee arthroscopically. Am J Sports Med 31:83–86PubMed
Metadaten
Titel
The location-specific healing response of damaged articular cartilage after ACL reconstruction: short-term follow-up
verfasst von
Norimasa Nakamura
Shuji Horibe
Yukiyoshi Toritsuka
Tomoki Mitsuoka
Takashi Natsu-ume
Kenji Yoneda
Masayuki Hamada
Yoshinari Tanaka
Richard S. Boorman
Hideki Yoshikawa
Konsei Shino
Publikationsdatum
01.09.2008
Verlag
Springer-Verlag
Erschienen in
Knee Surgery, Sports Traumatology, Arthroscopy / Ausgabe 9/2008
Print ISSN: 0942-2056
Elektronische ISSN: 1433-7347
DOI
https://doi.org/10.1007/s00167-008-0565-3

Weitere Artikel der Ausgabe 9/2008

Knee Surgery, Sports Traumatology, Arthroscopy 9/2008 Zur Ausgabe

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Mehr Frauen im OP – weniger postoperative Komplikationen

21.05.2024 Allgemeine Chirurgie Nachrichten

Ein Frauenanteil von mindestens einem Drittel im ärztlichen Op.-Team war in einer großen retrospektiven Studie aus Kanada mit einer signifikanten Reduktion der postoperativen Morbidität assoziiert.

TEP mit Roboterhilfe führt nicht zu größerer Zufriedenheit

15.05.2024 Knie-TEP Nachrichten

Der Einsatz von Operationsrobotern für den Einbau von Totalendoprothesen des Kniegelenks hat die Präzision der Eingriffe erhöht. Für die postoperative Zufriedenheit der Patienten scheint das aber unerheblich zu sein, wie eine Studie zeigt.

Lever-Sign-Test hilft beim Verdacht auf Kreuzbandriss

15.05.2024 Vordere Kreuzbandruptur Nachrichten

Mit dem Hebelzeichen-Test lässt sich offenbar recht zuverlässig feststellen, ob ein vorderes Kreuzband gerissen ist. In einer Metaanalyse war die Vorhersagekraft vor allem bei positivem Testergebnis hoch.

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

07.05.2024 Klinik aktuell Nachrichten

Extreme Arbeitsverdichtung und kaum Supervision: Dr. Andrea Martini, Sprecherin des Bündnisses Junge Ärztinnen und Ärzte (BJÄ) über den Frust des ärztlichen Nachwuchses und die Vorteile des Rucksack-Modells.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.