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Graefe's Archive for Clinical and Experimental Ophthalmology

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22.05.2020 | Retinal Disorders

The long-term effect of human immunodeficiency virus infection on retinal microvasculature and the ganglion cell–inner plexiform layer: an OCT angiography study

verfasst von: Berkay Akmaz, Fahrettin Akay, Yusuf Ziya Güven, Figen Kaptan, Tuna Demirdal

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 8/2020

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Abstract

Purpose

To investigate the long-term effect of HIV infection on the ganglion cell–inner plexiform layer and retinal capillary network.

Methods

This prospective, cross-sectional case-control study included 45 HIV-infected patients and 45 healthy individuals. Optical coherence tomography angiography (OCTA) was used for the assessment of macular, peripapillary retinal nerve fiber layer (RNFL) thicknesses, ganglion cell–inner plexiform layer, vessel density, perfusion density, and foveal avascular zone.

Results

The mean disease duration was 7.3 ± 1.9 years (range, 5–12 years) in the HIV group. The mean CD4 count (nadir) for all the patients was 147.09 ± 122 cells/mm³ and the mean RNA was 173.6 ± 913.8 copies/ml. No statistically significant difference was determined between the groups in respect of the average and foveal MT (p = 0.05). A significant difference was found between the two groups in respect of the mean VD and PD parameters (p < 0.05). Peripapillary PD was significantly decreased in the HIV group. There was a significant difference between the average and superior and inferior half-region of GC-IPL values. Using Pearson’s correlation analysis, no significant correlation was determined between the duration of HIV infection and mean GC-IPL, MT and VD, and PD values (r − 0.223, p 0.141; r − 0.223, p 0.141; r − 0.169, p 0.268; r − 0.105, p 0.491; r − 0.095, p 0.535 respectively).

Conclusions

The results of this study provide evidence of microvascular and neuroretinal loss in individuals with well-suppressed HIV infection, compared with healthy control subjects. OCTA is an important test for the screening of retinal microvascular changes over time in HIV-infected cases.

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Titel: The long-term effect of human immunodeficiency virus infection on retinal microvasculature and the ganglion cell–inner plexiform layer: an OCT angiography study
verfasst von: Berkay Akmaz
Fahrettin Akay
Yusuf Ziya Güven
Figen Kaptan
Tuna Demirdal
Publikationsdatum: 22.05.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 8/2020
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-020-04749-x

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The long-term effect of human immunodeficiency virus infection on retinal microvasculature and the ganglion cell–inner plexiform layer: an OCT angiography study

Abstract

Purpose

Methods

Results

Conclusions

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