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01.12.2018 | Review | Ausgabe 1/2018 Open Access

Journal of Translational Medicine 1/2018

The physiological role of Motin family and its dysregulation in tumorigenesis

Journal of Translational Medicine > Ausgabe 1/2018
Tingting Huang, Yuhang Zhou, Jinglin Zhang, Alfred S. L. Cheng, Jun Yu, Ka Fai To, Wei Kang
Wichtige Hinweise
Tingting Huang and Yuhang Zhou contributed equally to this work


Members in Motin family, or Angiomotins (AMOTs), are adaptor proteins that localize in the membranous, cytoplasmic or nuclear fraction in a cell context-dependent manner. They control the bioprocesses such as migration, tight junction formation, cell polarity, and angiogenesis. Emerging evidences have demonstrated that AMOTs participate in cancer initiation and progression. Many of the previous studies have focused on the involvement of AMOTs in Hippo-YAP1 pathway. However, it has been controversial for years that AMOTs serve as either positive or negative growth regulators in different cancer types because of the various cellular origins. The molecular mechanisms of these opposite roles of AMOTs remain elusive. This review comprehensively summarized how AMOTs function physiologically and how their dysregulation promotes or inhibits tumorigenesis. Better understanding the functional roles of AMOTs in cancers may lead to an improvement of clinical interventions as well as development of novel therapeutic strategies for cancer patients.
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