Erschienen in:
01.09.2004 | Poster presentation
The potential role of adiponectin in driving arthritis
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 3/2004
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Excerpt
Recent data indicate that adipose tissue synthesizes and releases numerous immunocompetent molecules such as tumor necrosis factor (TNF) alpha, C3a and C1-inhibitor. As adipose tissue is also part of rheumatoid joints, we examined whether adiponectin (apM-1), which has structural homologies to complement proteins and members of the TNF family, and its receptors are present in rheumatoid arthritis (RA) and osteoarthritis (OA) synovium. In addition, owing to the ability of adiponectin to exert several immunmodulatory functions, the effect and regulation of adiponectin-dependent synthesis of proinflammatory and antiinflammatory cytokines was examined. …