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European Archives of Oto-Rhino-Laryngology

Erschienen in:

01.11.2014 | Review Article

The presence of fungal-specific IgE in serum and sinonasal tissue among patients with sinonasal polyposis

verfasst von: M. Bakhshaee, M. Fereidouni, M. Nourollahian, R. Movahed

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 11/2014

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Abstract

Nasal polyposis (NP) is a common inflammatory disorder with different proposed etiologies. There is some evidence that the local production of specific IgE against fungal allergens may contribute to the pathogenesis of this condition. The aim of this study was to compare local and systemic production of fungal-specific IgE among patients with NP. In a prospective cross-sectional study, 141 patients with sinonasal polyposis who were surgical candidates were enrolled. Total IgE and fungal-specific IgE antibodies in serum and tissue homogenates were measured by the ELISA and ImmunoCAP method, respectively. Twelve cases (9.45 %) met the allergic fungal rhinosinusitis (AFRS) criteria while the remaining 129 patients showed histopathological features of chronic hyperplastic rhinosinusitis. Considering a cutoff point of 0.4 KUI/L for specific IgE as a positive reaction against fungal elements, seven and 62 cases showed positive results in serum and homogenate tissue, respectively. All serum positive reactions were seen among patients with AFRS. In conclusion, IgE antibody could be locally produced in the nasal polyp tissue while not detectable in the serum.

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Titel: The presence of fungal-specific IgE in serum and sinonasal tissue among patients with sinonasal polyposis
verfasst von: M. Bakhshaee
M. Fereidouni
M. Nourollahian
R. Movahed
Publikationsdatum: 01.11.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 11/2014
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-014-2882-0

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