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Erschienen in: Heart Failure Reviews 4/2016

22.03.2016

The role of pharmacotherapy in the prevention of sudden cardiac death in patients with heart failure

verfasst von: Phillip A. Weeks, Adam Sieg, Jennifer Ann Gass, Indranee Rajapreyar

Erschienen in: Heart Failure Reviews | Ausgabe 4/2016

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Abstract

Sudden cardiac death remains a significant threat to the survival of patients with heart failure. Long-term cardiac remodeling predisposes these patients to develop malignant ventricular arrhythmias. Permanent implantable and temporary external defibrillators remain a mainstay for the prevention of sudden cardiac death in this population. For decades, researchers have attempted to identify reliable drug therapies to avoid such arrhythmias; however, to date, success has been inconsistent. This review aims to explore the evidence defining the role of drug therapies for direct and indirect suppression of arrhythmias that may cause sudden cardiac death in patients with heart failure.
Literatur
1.
Zurück zum Zitat The CONSENSUS Trial Study Group (1987) Effects of enalapril on mortality in severe congestive heart failure: results of the Cooperative North Scandinavian Enalapril Survival Study. N Engl J Med 316:1429–1435CrossRef The CONSENSUS Trial Study Group (1987) Effects of enalapril on mortality in severe congestive heart failure: results of the Cooperative North Scandinavian Enalapril Survival Study. N Engl J Med 316:1429–1435CrossRef
2.
Zurück zum Zitat Pitt B, Zannad F, Remme WJ et al (1999) The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 341:709–717CrossRefPubMed Pitt B, Zannad F, Remme WJ et al (1999) The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 341:709–717CrossRefPubMed
3.
Zurück zum Zitat Chugh SS, Reinier K, Teodorescu C et al (2008) Epidemiology of sudden cardiac death: clinical and research implications. Prog Cardiovasc Dis 51:213–228CrossRefPubMedPubMedCentral Chugh SS, Reinier K, Teodorescu C et al (2008) Epidemiology of sudden cardiac death: clinical and research implications. Prog Cardiovasc Dis 51:213–228CrossRefPubMedPubMedCentral
4.
Zurück zum Zitat Stecker EC, Vickers C, Waltz J et al (2006) Population-based analysis of sudden cardiac death with and without left ventricular systolic dysfunction: two-year findings from the Oregon Sudden Unexpected Death Study. J Am Coll Cardiol 47:1161–1166CrossRefPubMed Stecker EC, Vickers C, Waltz J et al (2006) Population-based analysis of sudden cardiac death with and without left ventricular systolic dysfunction: two-year findings from the Oregon Sudden Unexpected Death Study. J Am Coll Cardiol 47:1161–1166CrossRefPubMed
5.
Zurück zum Zitat Rea TD, Pearce RM, Raghunathan TE et al (2004) Incidence of out-of-hospital cardiac arrest. Am J Cardiol 93:1455–1460CrossRefPubMed Rea TD, Pearce RM, Raghunathan TE et al (2004) Incidence of out-of-hospital cardiac arrest. Am J Cardiol 93:1455–1460CrossRefPubMed
7.
Zurück zum Zitat Mozaffarian D, Benjamin EJ, Go AS et al (2015) Heart disease and stroke statistics—2015 update: a report from the American Heart Association. Circulation 131:e29–e322CrossRefPubMed Mozaffarian D, Benjamin EJ, Go AS et al (2015) Heart disease and stroke statistics—2015 update: a report from the American Heart Association. Circulation 131:e29–e322CrossRefPubMed
8.
Zurück zum Zitat Huikuri HV, Castellanos A, Myerburg RJ (2001) Sudden death due to cardiac arrhythmia. N Engl J Med 345:1473–1482CrossRefPubMed Huikuri HV, Castellanos A, Myerburg RJ (2001) Sudden death due to cardiac arrhythmia. N Engl J Med 345:1473–1482CrossRefPubMed
9.
Zurück zum Zitat Bayes de Luna A, Coumel P, Leclereq JF (1989) Ambulatory sudden cardiac death: mechanisms of production of fatal arrhythmia on the basis of data from 157 cases. Am Heart J 117:151–159CrossRefPubMed Bayes de Luna A, Coumel P, Leclereq JF (1989) Ambulatory sudden cardiac death: mechanisms of production of fatal arrhythmia on the basis of data from 157 cases. Am Heart J 117:151–159CrossRefPubMed
10.
Zurück zum Zitat Yancy CW, Jessup M, Bozkurt B et al (2013) 2013 American College of Cardiology Foundation/American Heart Association guidelines for the management of heart failure. J Am Coll Cardiol 62:1495–1539CrossRef Yancy CW, Jessup M, Bozkurt B et al (2013) 2013 American College of Cardiology Foundation/American Heart Association guidelines for the management of heart failure. J Am Coll Cardiol 62:1495–1539CrossRef
11.
Zurück zum Zitat Priori SG, Blomstrom-Lundqvist C, Mazzanti A et al (2015) 2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J 36:2793–2867CrossRefPubMed Priori SG, Blomstrom-Lundqvist C, Mazzanti A et al (2015) 2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J 36:2793–2867CrossRefPubMed
12.
Zurück zum Zitat Zipes DP, Camm AJ et al (2006) ACC/AHA/ESC 2006 guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. J Am Coll Cardiol 48:e247–e346CrossRefPubMed Zipes DP, Camm AJ et al (2006) ACC/AHA/ESC 2006 guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. J Am Coll Cardiol 48:e247–e346CrossRefPubMed
13.
Zurück zum Zitat Reiter MJ, Stromberg KD, Whitman TA et al (2013) Influence of intra-cardiac pressure on spontaneous ventricular arrhythmias in patients with systolic heart failure: insights from the REDUCEhf Trial. Circ Arrhythm Electrophysiol 6:272–278CrossRefPubMed Reiter MJ, Stromberg KD, Whitman TA et al (2013) Influence of intra-cardiac pressure on spontaneous ventricular arrhythmias in patients with systolic heart failure: insights from the REDUCEhf Trial. Circ Arrhythm Electrophysiol 6:272–278CrossRefPubMed
15.
Zurück zum Zitat Cao JM, Chen LS, KenKnight BH et al (2000) Nerve sprouting and sudden cardiac death. Circ Res 86:816–821CrossRefPubMed Cao JM, Chen LS, KenKnight BH et al (2000) Nerve sprouting and sudden cardiac death. Circ Res 86:816–821CrossRefPubMed
16.
Zurück zum Zitat Fischer TH, Eiringhaus J, Dybkova N et al (2014) Ca2+/calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca2+ leak in human ischaemic and dilated cardiomyopathy. Eur J Heart Fail 16:1292–1300CrossRefPubMed Fischer TH, Eiringhaus J, Dybkova N et al (2014) Ca2+/calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca2+ leak in human ischaemic and dilated cardiomyopathy. Eur J Heart Fail 16:1292–1300CrossRefPubMed
17.
Zurück zum Zitat Kirchhefer U, Schmitz W, Scholz H et al (1999) Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and non-failing human hearts. Cardiovasc Res 42:254–261CrossRefPubMed Kirchhefer U, Schmitz W, Scholz H et al (1999) Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and non-failing human hearts. Cardiovasc Res 42:254–261CrossRefPubMed
18.
Zurück zum Zitat Ai X, Curran JW, Shannon TR et al (2005) Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circ Res 97:1314–1322CrossRefPubMed Ai X, Curran JW, Shannon TR et al (2005) Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circ Res 97:1314–1322CrossRefPubMed
19.
Zurück zum Zitat Van Oort RJ, McCauley MD, Dixit SS et al (2010) Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation 122:2669–2679CrossRefPubMedPubMedCentral Van Oort RJ, McCauley MD, Dixit SS et al (2010) Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation 122:2669–2679CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Bardy GH, Lee KL, Mark DB et al (2005) Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 352:225–237CrossRefPubMed Bardy GH, Lee KL, Mark DB et al (2005) Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 352:225–237CrossRefPubMed
21.
Zurück zum Zitat Herre JM, Sauve MJ, Malone P et al (1989) Long-term results of amiodarone therapy in patients with recurrent sustained ventricular tachycardia or ventricular fibrillation. J Am Coll Cardiol 13:442–449CrossRefPubMed Herre JM, Sauve MJ, Malone P et al (1989) Long-term results of amiodarone therapy in patients with recurrent sustained ventricular tachycardia or ventricular fibrillation. J Am Coll Cardiol 13:442–449CrossRefPubMed
22.
Zurück zum Zitat Connolly SJ, Hallstrom AP, Cappato R et al (2000) Meta-analysis of implantable cardioverter-defibrillator secondary prevention trials. Eur Heart J 21:2071–2078CrossRefPubMed Connolly SJ, Hallstrom AP, Cappato R et al (2000) Meta-analysis of implantable cardioverter-defibrillator secondary prevention trials. Eur Heart J 21:2071–2078CrossRefPubMed
23.
Zurück zum Zitat Reddy VY, Reynolds MR, Neuzil P et al (2007) Prophylactic catheter ablation for the prevention of defibrillator therapy. N Engl J Med 357:2657–2665CrossRefPubMedPubMedCentral Reddy VY, Reynolds MR, Neuzil P et al (2007) Prophylactic catheter ablation for the prevention of defibrillator therapy. N Engl J Med 357:2657–2665CrossRefPubMedPubMedCentral
24.
Zurück zum Zitat Kuck KH, Schaumann A, Eckardt L et al (2010) Catheter ablation of stable ventricular tachycardia before defibrillator implantation in patients with coronary heart disease (VTACH): a multicenter randomized controlled trial. Lancet 375:31–40CrossRefPubMed Kuck KH, Schaumann A, Eckardt L et al (2010) Catheter ablation of stable ventricular tachycardia before defibrillator implantation in patients with coronary heart disease (VTACH): a multicenter randomized controlled trial. Lancet 375:31–40CrossRefPubMed
25.
26.
Zurück zum Zitat Echt DS, Liebson PR, Mitchell LB et al (1991) Mortality and morbidity in patients receiving encainide, flecainide, or placebo: the Cardiac Arrhythmia Suppression Trial. N Engl J Med 324:781–788CrossRefPubMed Echt DS, Liebson PR, Mitchell LB et al (1991) Mortality and morbidity in patients receiving encainide, flecainide, or placebo: the Cardiac Arrhythmia Suppression Trial. N Engl J Med 324:781–788CrossRefPubMed
27.
Zurück zum Zitat Verlinden NJ, Coons JC (2015) Disopyramide for hypertrophic cardiomyopathy: a pragmatic reappraisal of an old drug. Pharmacotherapy 35:1164–1172CrossRefPubMed Verlinden NJ, Coons JC (2015) Disopyramide for hypertrophic cardiomyopathy: a pragmatic reappraisal of an old drug. Pharmacotherapy 35:1164–1172CrossRefPubMed
28.
Zurück zum Zitat U.K. Rythmodan Multicentre Study Group (1984) Oral disopyramide after admission to hospital with suspected acute myocardial infarction. Postgrad Med J 60:98–107CrossRef U.K. Rythmodan Multicentre Study Group (1984) Oral disopyramide after admission to hospital with suspected acute myocardial infarction. Postgrad Med J 60:98–107CrossRef
29.
Zurück zum Zitat Belhassen B, Glick A, Viskin S et al (2004) Efficacy of quinidine in high-risk patients with Brugada syndrome. Circulation 110:1731–1737CrossRefPubMed Belhassen B, Glick A, Viskin S et al (2004) Efficacy of quinidine in high-risk patients with Brugada syndrome. Circulation 110:1731–1737CrossRefPubMed
30.
Zurück zum Zitat Alings M, Dekker L, Sadee A et al (2001) Quinidine induced electrocardiographic normalization in two patients with Brugada syndrome. Pacing Clin Electrophysiol 24:1420–1422CrossRefPubMed Alings M, Dekker L, Sadee A et al (2001) Quinidine induced electrocardiographic normalization in two patients with Brugada syndrome. Pacing Clin Electrophysiol 24:1420–1422CrossRefPubMed
31.
Zurück zum Zitat Sharma AD, Purves P, Yee R et al (1990) Hemodynamic effects of intravenous procainamide during ventricular tachycardia. Am Heart J 119:1034–1041CrossRefPubMed Sharma AD, Purves P, Yee R et al (1990) Hemodynamic effects of intravenous procainamide during ventricular tachycardia. Am Heart J 119:1034–1041CrossRefPubMed
32.
Zurück zum Zitat Hine LK, Laird N, Hewitt P et al (1989) Meta-analytic evidence against prophylactic use of lidocaine in acute myocardial infarction. Arch Intern Med 149:2694–2698CrossRefPubMed Hine LK, Laird N, Hewitt P et al (1989) Meta-analytic evidence against prophylactic use of lidocaine in acute myocardial infarction. Arch Intern Med 149:2694–2698CrossRefPubMed
33.
Zurück zum Zitat MacMahon S, Collins R, Peto R et al (1988) Effects of prophylactic lidocaine in suspected acute myocardial infarction: an overview of results from the randomized, controlled trials. JAMA 260:1910–1916CrossRefPubMed MacMahon S, Collins R, Peto R et al (1988) Effects of prophylactic lidocaine in suspected acute myocardial infarction: an overview of results from the randomized, controlled trials. JAMA 260:1910–1916CrossRefPubMed
34.
Zurück zum Zitat Singh S, Klein R, Eisenberg B et al (1990) Long-term effect of mexiletine on left ventricular function and relation to suppression of ventricular arrhythmia. Am J Cardiol 66:1222–1227CrossRefPubMed Singh S, Klein R, Eisenberg B et al (1990) Long-term effect of mexiletine on left ventricular function and relation to suppression of ventricular arrhythmia. Am J Cardiol 66:1222–1227CrossRefPubMed
35.
Zurück zum Zitat Chamberlain DA, Jewitt DE, Julian DG et al (1980) Oral mexiletine in high-risk patients after myocardial infarction. Lancet 2:1324–1327CrossRefPubMed Chamberlain DA, Jewitt DE, Julian DG et al (1980) Oral mexiletine in high-risk patients after myocardial infarction. Lancet 2:1324–1327CrossRefPubMed
36.
Zurück zum Zitat Stein J, Podrid P, Lown B (1984) Effects of oral mexiletine on left and right ventricular function. Am J Cardiol 54:575–578CrossRefPubMed Stein J, Podrid P, Lown B (1984) Effects of oral mexiletine on left and right ventricular function. Am J Cardiol 54:575–578CrossRefPubMed
37.
Zurück zum Zitat Cardiac Arrhythmia Suppression Trial II Investigators (1992) Effect of the antiarrhythmic agent moricizine on survival after myocardial infarction. N Engl J Med 327:227–233CrossRef Cardiac Arrhythmia Suppression Trial II Investigators (1992) Effect of the antiarrhythmic agent moricizine on survival after myocardial infarction. N Engl J Med 327:227–233CrossRef
38.
Zurück zum Zitat Kuck KH, Cappato R, Siebels J et al (2000) Randomized comparison of antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from cardiac arrest: the Cardiac Arrest Study Hamburg (CASH). Circulation 102:748–754CrossRefPubMed Kuck KH, Cappato R, Siebels J et al (2000) Randomized comparison of antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from cardiac arrest: the Cardiac Arrest Study Hamburg (CASH). Circulation 102:748–754CrossRefPubMed
39.
Zurück zum Zitat Burkart F, Pfisterer M, Kiowski W et al (1990) Effect of antiarrhythmic therapy on mortality in survivors of myocardial infarction with asymptomatic complex ventricular arrhythmias: Basel Antiarrhythmic Study of Infarct Survival (BASIS). J Am Coll Cardiol 16:1711–1718CrossRefPubMed Burkart F, Pfisterer M, Kiowski W et al (1990) Effect of antiarrhythmic therapy on mortality in survivors of myocardial infarction with asymptomatic complex ventricular arrhythmias: Basel Antiarrhythmic Study of Infarct Survival (BASIS). J Am Coll Cardiol 16:1711–1718CrossRefPubMed
40.
Zurück zum Zitat Doval HC, Nul DR, Grancelli HO et al (1994) Randomised trial of low-dose amiodarone in severe congestive heart failure. Grupo de Estudio de la Sobrvida en la insuficiencia cardiac en Argentina. Lancet 344:493–498CrossRefPubMed Doval HC, Nul DR, Grancelli HO et al (1994) Randomised trial of low-dose amiodarone in severe congestive heart failure. Grupo de Estudio de la Sobrvida en la insuficiencia cardiac en Argentina. Lancet 344:493–498CrossRefPubMed
41.
Zurück zum Zitat Singh SN, Fletcher RD, Gross Fisher S et al (1995) Amiodarone in patients with congestive heart failure and asymptomatic ventricular arrhythmia. N Engl J Med 333:77–82CrossRefPubMed Singh SN, Fletcher RD, Gross Fisher S et al (1995) Amiodarone in patients with congestive heart failure and asymptomatic ventricular arrhythmia. N Engl J Med 333:77–82CrossRefPubMed
42.
Zurück zum Zitat Julian DG, Camm AJ, Frangin G et al (1997) Randomised trial of effect of amiodarone on mortality in patients with left-ventricular dysfunction after recent myocardial infarction: EMIAT. Lancet 349:667–674CrossRefPubMed Julian DG, Camm AJ, Frangin G et al (1997) Randomised trial of effect of amiodarone on mortality in patients with left-ventricular dysfunction after recent myocardial infarction: EMIAT. Lancet 349:667–674CrossRefPubMed
43.
Zurück zum Zitat Cairns JA, Connolly SJ, Roberts R et al (1997) Randomised trial of outcomes after myocardial infarction in patients with frequent or repetitive ventricular premature depolarisations: CAMIAT. Lancet 349:675–682CrossRefPubMed Cairns JA, Connolly SJ, Roberts R et al (1997) Randomised trial of outcomes after myocardial infarction in patients with frequent or repetitive ventricular premature depolarisations: CAMIAT. Lancet 349:675–682CrossRefPubMed
44.
Zurück zum Zitat Connolly S, Cairns J, Gent M, (Amiodarone Trials Meta-Analysis Investigators) et al (1997) Effect of prophylactic amiodarone on mortality after acute myocardial infarction and in congestive heart failure: meta-analysis of individual data from 6500 patients in randomized trials. Lancet 350:1417–1424CrossRef Connolly S, Cairns J, Gent M, (Amiodarone Trials Meta-Analysis Investigators) et al (1997) Effect of prophylactic amiodarone on mortality after acute myocardial infarction and in congestive heart failure: meta-analysis of individual data from 6500 patients in randomized trials. Lancet 350:1417–1424CrossRef
45.
Zurück zum Zitat Piccini JP, Berger JS, O’Connor CM (2009) Amiodarone for the prevention of sudden cardiac death: a meta-analysis of randomized trials. Eur Heart J 30:1245–1253CrossRefPubMed Piccini JP, Berger JS, O’Connor CM (2009) Amiodarone for the prevention of sudden cardiac death: a meta-analysis of randomized trials. Eur Heart J 30:1245–1253CrossRefPubMed
46.
Zurück zum Zitat Kober L, Torp-Pederson C, McMurray JJV et al (2008) Increased mortality after dronedarone therapy for severe heart failure. N Engl J Med 358:2678–2687CrossRefPubMed Kober L, Torp-Pederson C, McMurray JJV et al (2008) Increased mortality after dronedarone therapy for severe heart failure. N Engl J Med 358:2678–2687CrossRefPubMed
47.
Zurück zum Zitat Waldo AL, Camm AJ, deRuyter H et al (1996) Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. Lancet 348:7–12CrossRefPubMed Waldo AL, Camm AJ, deRuyter H et al (1996) Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. Lancet 348:7–12CrossRefPubMed
48.
Zurück zum Zitat Kuhlkamp V, Mewis C, Mermi J et al (1999) Suppression of sustained ventricular tachyarrhythmias: a comparison of d,l-sotalol with no antiarrhythmic drug treatment. J Am Coll Cardiol 33:46–52CrossRefPubMed Kuhlkamp V, Mewis C, Mermi J et al (1999) Suppression of sustained ventricular tachyarrhythmias: a comparison of d,l-sotalol with no antiarrhythmic drug treatment. J Am Coll Cardiol 33:46–52CrossRefPubMed
49.
Zurück zum Zitat Pacifico A, Hohnloser SH, Williams JH et al (1999) Prevention of implantable-defibrillator shocks by treatment with sotalol. N Engl J Med 340:1855–1862CrossRefPubMed Pacifico A, Hohnloser SH, Williams JH et al (1999) Prevention of implantable-defibrillator shocks by treatment with sotalol. N Engl J Med 340:1855–1862CrossRefPubMed
50.
Zurück zum Zitat Torp-Pedersen C, Moller M, Thomsen PEB, (DIAMOND Study Group) et al (1999) Dofetilide in patients with congestive heart failure and left ventricular dysfunction. N Engl J Med 341:857–865CrossRefPubMed Torp-Pedersen C, Moller M, Thomsen PEB, (DIAMOND Study Group) et al (1999) Dofetilide in patients with congestive heart failure and left ventricular dysfunction. N Engl J Med 341:857–865CrossRefPubMed
51.
Zurück zum Zitat Kober L, Thomsen PEB, Moller M, (DIAMOND Study Group) et al (2000) Effect of dofetilide in patients with recent myocardial infarction and left-ventricular dysfunction: a randomized trial. Lancet 356:2052–2058CrossRefPubMed Kober L, Thomsen PEB, Moller M, (DIAMOND Study Group) et al (2000) Effect of dofetilide in patients with recent myocardial infarction and left-ventricular dysfunction: a randomized trial. Lancet 356:2052–2058CrossRefPubMed
52.
Zurück zum Zitat Mann DL, Bristow MR (2005) Mechanisms and models in heart failure: the biomechanical model and beyond. Circulation 11:2837–2849CrossRef Mann DL, Bristow MR (2005) Mechanisms and models in heart failure: the biomechanical model and beyond. Circulation 11:2837–2849CrossRef
54.
Zurück zum Zitat Chekakie MO (2012) Traditional heart failure medications and sudden cardiac death prevention: a review. J Cardiovasc Pharmacol Ther 18:412–426CrossRef Chekakie MO (2012) Traditional heart failure medications and sudden cardiac death prevention: a review. J Cardiovasc Pharmacol Ther 18:412–426CrossRef
55.
Zurück zum Zitat Packer M, Bristow MR, Cohn JN et al (1996) The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. N Engl J Med 334:1349–1355CrossRefPubMed Packer M, Bristow MR, Cohn JN et al (1996) The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. N Engl J Med 334:1349–1355CrossRefPubMed
56.
Zurück zum Zitat CIBIS-II Investigators and Committees (1999) The Cardiac Insufficiency Bisoprolol Study II (CIBIS II): a randomised trial. Lancet 353:9–13 CrossRef CIBIS-II Investigators and Committees (1999) The Cardiac Insufficiency Bisoprolol Study II (CIBIS II): a randomised trial. Lancet 353:9–13 CrossRef
57.
Zurück zum Zitat Hjalmarson A, Goldstein S, Fagerberg B et al (2000) Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure. JAMA 283:1285–1302CrossRef Hjalmarson A, Goldstein S, Fagerberg B et al (2000) Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure. JAMA 283:1285–1302CrossRef
58.
Zurück zum Zitat Bristow MR, Gilbert EM, Abraham WT et al (1996) Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. Circulation 94:2807–2816CrossRefPubMed Bristow MR, Gilbert EM, Abraham WT et al (1996) Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. Circulation 94:2807–2816CrossRefPubMed
59.
Zurück zum Zitat Packer M, Coats AJS, Fowler MB et al (2001) Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med 344:1651–1658CrossRefPubMed Packer M, Coats AJS, Fowler MB et al (2001) Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med 344:1651–1658CrossRefPubMed
60.
Zurück zum Zitat Packer M, Fowler MB, Roecker EB et al (2002) Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the COPERNICUS Study. Circulation 106:2194–2199CrossRefPubMed Packer M, Fowler MB, Roecker EB et al (2002) Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the COPERNICUS Study. Circulation 106:2194–2199CrossRefPubMed
61.
Zurück zum Zitat CIBIS Investigators and Committees (1994) A randomized trial of beta-blockade in heart failure. The Cardiac Insufficiency Bisoprolol Study (CIBIS). Circulation 1994(90):1765–1773 CIBIS Investigators and Committees (1994) A randomized trial of beta-blockade in heart failure. The Cardiac Insufficiency Bisoprolol Study (CIBIS). Circulation 1994(90):1765–1773
62.
Zurück zum Zitat Poole-Wilson P, Swedberg K, Cleland J et al (2003) Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial. Lancet 362:7–13CrossRefPubMed Poole-Wilson P, Swedberg K, Cleland J et al (2003) Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial. Lancet 362:7–13CrossRefPubMed
63.
Zurück zum Zitat The Beta-Blocker Evaluation of Survival Trial Investigators (2001) A trial of the beta-blocker bucindolol in patients with advanced chronic heart failure. N Engl J Med 344:1659–1667CrossRef The Beta-Blocker Evaluation of Survival Trial Investigators (2001) A trial of the beta-blocker bucindolol in patients with advanced chronic heart failure. N Engl J Med 344:1659–1667CrossRef
64.
Zurück zum Zitat CAPRICORN Investigators (2001) Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. Lancet 357:1385–1390CrossRef CAPRICORN Investigators (2001) Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial. Lancet 357:1385–1390CrossRef
65.
Zurück zum Zitat Al-Gobari M, Khatib CE, Pillon F et al (2013) Beta-blockers for the prevention of sudden cardiac death in heart failure patients: a meta-analysis of randomized controlled trials. BMC Cardiovasc Disord 13:52–60CrossRefPubMedPubMedCentral Al-Gobari M, Khatib CE, Pillon F et al (2013) Beta-blockers for the prevention of sudden cardiac death in heart failure patients: a meta-analysis of randomized controlled trials. BMC Cardiovasc Disord 13:52–60CrossRefPubMedPubMedCentral
66.
Zurück zum Zitat Domanski MJ, Exner DV, Borkowf CB et al (1999) Effect of angiotensin converting enzyme inhibition on sudden cardiac death in patients following acute myocardial infraction. J Am Coll Cardiol 33:598–604CrossRefPubMed Domanski MJ, Exner DV, Borkowf CB et al (1999) Effect of angiotensin converting enzyme inhibition on sudden cardiac death in patients following acute myocardial infraction. J Am Coll Cardiol 33:598–604CrossRefPubMed
67.
Zurück zum Zitat Cleland JG, Erhardt L, Murray G et al (1993) Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. The Acute Infarction Ramipril Efficacy (AIRE) Study Investigators. Lancet 342:821–828 Cleland JG, Erhardt L, Murray G et al (1993) Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. The Acute Infarction Ramipril Efficacy (AIRE) Study Investigators. Lancet 342:821–828
68.
Zurück zum Zitat Cleland JG, Erhardt L, Murray G et al (1997) Effect of ramipril on morbidity and mode of death among survivors of acute myocardial infarction with clinical evidence of heart failure. A report from the AIRE Study Investigators. Eur Heart J 18:41–51CrossRefPubMed Cleland JG, Erhardt L, Murray G et al (1997) Effect of ramipril on morbidity and mode of death among survivors of acute myocardial infarction with clinical evidence of heart failure. A report from the AIRE Study Investigators. Eur Heart J 18:41–51CrossRefPubMed
69.
Zurück zum Zitat Kober L, Torp-Pedersen C, Carlsen JE et al (1995) A clinical trial of the angiotensin-converting-enzyme inhibitor trandolapril in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 333:1670–1676CrossRefPubMed Kober L, Torp-Pedersen C, Carlsen JE et al (1995) A clinical trial of the angiotensin-converting-enzyme inhibitor trandolapril in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 333:1670–1676CrossRefPubMed
70.
Zurück zum Zitat Naccarella F, Naccarelli GV, Maranga SS et al (2002) Do ACE inhibitors or angiotensin II antagonists reduce total mortality and arrhythmic mortality? A critical review of controlled clinical trials. Curr Opin Cardiol 17:6–18CrossRefPubMed Naccarella F, Naccarelli GV, Maranga SS et al (2002) Do ACE inhibitors or angiotensin II antagonists reduce total mortality and arrhythmic mortality? A critical review of controlled clinical trials. Curr Opin Cardiol 17:6–18CrossRefPubMed
71.
Zurück zum Zitat Cohn JN, Johnson G, Ziesche S et al (1991) A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N Engl J Med 325:303–310CrossRefPubMed Cohn JN, Johnson G, Ziesche S et al (1991) A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N Engl J Med 325:303–310CrossRefPubMed
72.
Zurück zum Zitat Pitt B, Segal R, Martinez FA et al (1997) Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE). Lancet 349:747–752CrossRefPubMed Pitt B, Segal R, Martinez FA et al (1997) Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE). Lancet 349:747–752CrossRefPubMed
73.
Zurück zum Zitat Pitt B, Poole-Wilson PA, Segal R et al (2000) Effect of losartan compared with captopril in patients with symptomatic heart failure: randomised trial—the Losartan Heart Failure Survival Study ELITE II. Lancet 355:1582–1587CrossRefPubMed Pitt B, Poole-Wilson PA, Segal R et al (2000) Effect of losartan compared with captopril in patients with symptomatic heart failure: randomised trial—the Losartan Heart Failure Survival Study ELITE II. Lancet 355:1582–1587CrossRefPubMed
74.
Zurück zum Zitat Dickstein K, Kjekshus J, the OPTIMAAL Steering Committee (2002) Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial. Lancet 360:752–760CrossRefPubMed Dickstein K, Kjekshus J, the OPTIMAAL Steering Committee (2002) Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial. Lancet 360:752–760CrossRefPubMed
75.
Zurück zum Zitat Granger CB, McMurray J, Yusuf S et al (2003) Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial. Lancet 362:772–776CrossRefPubMed Granger CB, McMurray J, Yusuf S et al (2003) Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial. Lancet 362:772–776CrossRefPubMed
76.
Zurück zum Zitat McMurray J, Ostergren J, Swedberg K et al (2003) Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial. Lancet 362:767–771CrossRefPubMed McMurray J, Ostergren J, Swedberg K et al (2003) Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial. Lancet 362:767–771CrossRefPubMed
77.
Zurück zum Zitat Solomon SD, Wang D, Finn P et al (2004) Effect of candesartan on cause-specific mortality in heart failure patients. Circulation 110:2180–2183CrossRefPubMed Solomon SD, Wang D, Finn P et al (2004) Effect of candesartan on cause-specific mortality in heart failure patients. Circulation 110:2180–2183CrossRefPubMed
78.
Zurück zum Zitat Konstam MA, Neaton JD, Dickstein K et al (2009) Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial. Lancet 374:1840–1848CrossRefPubMed Konstam MA, Neaton JD, Dickstein K et al (2009) Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial. Lancet 374:1840–1848CrossRefPubMed
79.
Zurück zum Zitat Zannad F, Dousset B, Alla F (2001) Treatment of congestive heart failure: interfering the aldosterone-cardiac extracellular matrix relationship. Hypertension 38(5):1227–1232CrossRefPubMed Zannad F, Dousset B, Alla F (2001) Treatment of congestive heart failure: interfering the aldosterone-cardiac extracellular matrix relationship. Hypertension 38(5):1227–1232CrossRefPubMed
80.
Zurück zum Zitat Pitt B, Remme W, Zannad F et al (2003) Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 348:1309–1321CrossRefPubMed Pitt B, Remme W, Zannad F et al (2003) Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 348:1309–1321CrossRefPubMed
81.
Zurück zum Zitat Zannad F, McMurray J, Krum H et al (2011) Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med 364:11–21CrossRefPubMed Zannad F, McMurray J, Krum H et al (2011) Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med 364:11–21CrossRefPubMed
83.
Zurück zum Zitat Pedersen TR, Kjekshus J, Berg K et al (1994) Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Survival Study (4s). Lancet 344(8934):1383–1389 Pedersen TR, Kjekshus J, Berg K et al (1994) Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Survival Study (4s). Lancet 344(8934):1383–1389
84.
Zurück zum Zitat LaRosa J, Grundy S, Waters D et al (2005) Intensive lipid lowering with atorvastatin in patients with stable coronary disease. N Engl J Med 352(14):1425–1435CrossRefPubMed LaRosa J, Grundy S, Waters D et al (2005) Intensive lipid lowering with atorvastatin in patients with stable coronary disease. N Engl J Med 352(14):1425–1435CrossRefPubMed
85.
Zurück zum Zitat Nissen S, Nicholls S, Sipahi I et al (2006) Effect of very high-intensity statin therapy on regression of coronary atherosclerosis. JAMA 295:1556–1565CrossRefPubMed Nissen S, Nicholls S, Sipahi I et al (2006) Effect of very high-intensity statin therapy on regression of coronary atherosclerosis. JAMA 295:1556–1565CrossRefPubMed
86.
Zurück zum Zitat Shanes J, Minadeo K, Moret A et al (2007) Statin therapy in heart failure: prognostic effects and potential mechanisms. Am Heart J 154:617–623CrossRefPubMed Shanes J, Minadeo K, Moret A et al (2007) Statin therapy in heart failure: prognostic effects and potential mechanisms. Am Heart J 154:617–623CrossRefPubMed
87.
Zurück zum Zitat Bonetti P, Lerman L, Napoli C et al (2003) Statin effects beyond lipid lowering—are they clinically relevant? Eur Heart J 24:225–248CrossRefPubMed Bonetti P, Lerman L, Napoli C et al (2003) Statin effects beyond lipid lowering—are they clinically relevant? Eur Heart J 24:225–248CrossRefPubMed
88.
Zurück zum Zitat Fonarow G, Wright R, Spencer F et al (2005) Effect of statin use within the first 24 hours of admission for acute myocardial infarction on early morbidity and mortality. Am J Cardiol 96:611–616CrossRefPubMed Fonarow G, Wright R, Spencer F et al (2005) Effect of statin use within the first 24 hours of admission for acute myocardial infarction on early morbidity and mortality. Am J Cardiol 96:611–616CrossRefPubMed
89.
Zurück zum Zitat Mitchell L, Powell J, Gillis A et al (2003) Are lipid-lowering drugs also antiarrhythmic drugs? An analysis of the antiarrhythmics versus implantable defibrillators (AVID) trial. J Am Coll Cardiol 42:81–87CrossRefPubMed Mitchell L, Powell J, Gillis A et al (2003) Are lipid-lowering drugs also antiarrhythmic drugs? An analysis of the antiarrhythmics versus implantable defibrillators (AVID) trial. J Am Coll Cardiol 42:81–87CrossRefPubMed
90.
Zurück zum Zitat Vyas A, Guo H, Moss A et al (2006) Reduction in ventricular tachyarrhythmias with statins in the multicenter automatic defibrillator implantation trial (MADIT)-II. J Am Coll Cardiol 47:769–773CrossRefPubMed Vyas A, Guo H, Moss A et al (2006) Reduction in ventricular tachyarrhythmias with statins in the multicenter automatic defibrillator implantation trial (MADIT)-II. J Am Coll Cardiol 47:769–773CrossRefPubMed
91.
Zurück zum Zitat Liao Y, Hsieh Y, Hung C et al (2013) Statin therapy reduces the risk of ventricular arrhythmias, sudden cardiac death, and mortality in heart failure patients: a nationwide population-based cohort study. Int J Cardiol 168(5):4805–4807CrossRefPubMed Liao Y, Hsieh Y, Hung C et al (2013) Statin therapy reduces the risk of ventricular arrhythmias, sudden cardiac death, and mortality in heart failure patients: a nationwide population-based cohort study. Int J Cardiol 168(5):4805–4807CrossRefPubMed
92.
Zurück zum Zitat Vrtovec B, Okrajsek R, Golicnik A et al (2008) Atorvastatin therapy may reduce the incidence of sudden cardiac death in patients with advanced chronic heart failure. J Card Fail 14:140–144CrossRefPubMed Vrtovec B, Okrajsek R, Golicnik A et al (2008) Atorvastatin therapy may reduce the incidence of sudden cardiac death in patients with advanced chronic heart failure. J Card Fail 14:140–144CrossRefPubMed
93.
Zurück zum Zitat Goldberger J, Subacius H, Schaechter A et al (2006) Effects of statin therapy on arrhythmic events and survival in patients with non-ischemic dilated cardiomyopathy. J Am Coll Cardiol 48:1228–1233CrossRefPubMed Goldberger J, Subacius H, Schaechter A et al (2006) Effects of statin therapy on arrhythmic events and survival in patients with non-ischemic dilated cardiomyopathy. J Am Coll Cardiol 48:1228–1233CrossRefPubMed
94.
Zurück zum Zitat Kjekshus J, Apetrei E, Barrios V et al (2007) Rosuvastatin in older patients with systolic heart failure. N Engl J Med 357(22):2248–2261CrossRefPubMed Kjekshus J, Apetrei E, Barrios V et al (2007) Rosuvastatin in older patients with systolic heart failure. N Engl J Med 357(22):2248–2261CrossRefPubMed
95.
Zurück zum Zitat Tavazzi L, Maggioni AP, Marchioli R et al (2008) Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomized, double-blind, placebo-controlled trial. Lancet 372:1231–1239CrossRefPubMed Tavazzi L, Maggioni AP, Marchioli R et al (2008) Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomized, double-blind, placebo-controlled trial. Lancet 372:1231–1239CrossRefPubMed
96.
Zurück zum Zitat Wang J, Wu G, Wang Z et al (2014) Long-term clinical outcomes of statin use for chronic heart failure: a meta-analysis of 15 prospective studies. Heart Lung Circ 23:105–113CrossRefPubMed Wang J, Wu G, Wang Z et al (2014) Long-term clinical outcomes of statin use for chronic heart failure: a meta-analysis of 15 prospective studies. Heart Lung Circ 23:105–113CrossRefPubMed
97.
Zurück zum Zitat Gheorghiage M, Bohm M, Greene S et al (2013) Effect of aliskiren on postdischarge mortality and heart failure readmissions among patients hospitalized for heart failure. JAMA 309(11):1125–1135CrossRef Gheorghiage M, Bohm M, Greene S et al (2013) Effect of aliskiren on postdischarge mortality and heart failure readmissions among patients hospitalized for heart failure. JAMA 309(11):1125–1135CrossRef
98.
Zurück zum Zitat Tavazzi L, Maggioni A, Marchioli R et al (2008) Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomized, double-blind, placebo-controlled trial. Lancet 372:1223–1230CrossRefPubMed Tavazzi L, Maggioni A, Marchioli R et al (2008) Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomized, double-blind, placebo-controlled trial. Lancet 372:1223–1230CrossRefPubMed
Metadaten
Titel
The role of pharmacotherapy in the prevention of sudden cardiac death in patients with heart failure
verfasst von
Phillip A. Weeks
Adam Sieg
Jennifer Ann Gass
Indranee Rajapreyar
Publikationsdatum
22.03.2016
Verlag
Springer US
Erschienen in
Heart Failure Reviews / Ausgabe 4/2016
Print ISSN: 1382-4147
Elektronische ISSN: 1573-7322
DOI
https://doi.org/10.1007/s10741-016-9546-7

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